PDB: 468 件ウェブページステータス検索Chemie searchBIRD

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7KRY	Co-crystal structure of alpha glucosidase with compound 11 分子名称: (1S,2S,3R,4S,5S)-5-({6-[(4-azido-2-nitrophenyl)amino]hexyl}amino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, CALCIUM ION, ... 著者 Karade, S.S, Mariuzza, R.A. 登録日 2020-11-20 公開日 2021-12-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity. J.Med.Chem., 64, 2021
7LYG	Zika virus RNA promoter stem-loop A with tRNA-scaffold 分子名称: RNA promoter stem-loop A fused with tRNA 著者 Lee, E.H, Choi, K.H. 登録日 2021-03-06 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.804 Å) 主引用文献 Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase. Nat Commun, 12, 2021
7L9E	Crystal structure of apo-alpha glucosidase 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Karade, S.S, Mariuzza, R.A. 登録日 2021-01-03 公開日 2021-12-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity. J.Med.Chem., 64, 2021
5F0E	Murine endoplasmic reticulum alpha-glucosidase II 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Caputo, A.T, Roversi, P, Alonzi, D.S, Kiappes, J.L, Zitzmann, N. 登録日 2015-11-27 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals. Proc.Natl.Acad.Sci.USA, 113, 2016
5GZR	Zika virus E protein complexed with a neutralizing antibody Z23-Fab 分子名称: Z23 Fab heavy chain, Z23 Fab light chain, structural protein E, ... 著者 Gao, G.G, Shi, Y, Peng, R, Liu, S. 登録日 2016-10-01 公開日 2016-11-30 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (9.4 Å) 主引用文献 Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
5GJB	Zika virus NS3 helicase in complex with ssRNA 分子名称: NS3 helicase, RNA (5'-R(*AP*GP*AP*UP*CP*AP*A)-3') 著者 Tian, H.L, Ji, X.Y, Yang, X.Y, Zhang, Z.X, Lu, Z.K, Yang, K.L, Chen, C, Zhao, Q, Chi, H, Mu, Z.Y, Xie, W, Wang, Z.F, Lou, H.Q, Yang, H.T, Rao, Z.H. 登録日 2016-06-28 公開日 2016-07-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.702 Å) 主引用文献 Structural basis of Zika virus helicase in recognizing its substrates Protein Cell, 7, 2016
5GP1	Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH 分子名称: NICKEL (II) ION, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, RNA-directed RNA polymerase NS5, ... 著者 Zhang, C, Jin, T. 登録日 2016-07-30 公開日 2016-12-07 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.444 Å) 主引用文献 Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design Biochem. Biophys. Res. Commun., 492, 2017
5GJC	Zika virus NS3 helicase in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, NS3 helicase 著者 Tian, H.L, Ji, X.Y, Yang, X.Y, Zhang, Z.X, Lu, Z.K, Yang, K.L, Chen, C, Zhao, Q, Chi, H, Mu, Z.Y, Xie, W, Wang, Z.F, Lou, H.Q, Yang, H.T, Rao, Z.H. 登録日 2016-06-28 公開日 2016-07-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.204 Å) 主引用文献 Structural basis of Zika virus helicase in recognizing its substrates Protein Cell, 7, 2016
5GOZ	Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH 分子名称: GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, PYROPHOSPHATE 2-, ... 著者 Zhang, C, Jin, T. 登録日 2016-07-30 公開日 2016-12-07 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.049 Å) 主引用文献 Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design Biochem. Biophys. Res. Commun., 492, 2017
5H32	Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 分子名称: C10 IgG heavy chain variable region, C10 IgG light chain variable region, structural protein E 著者 Zhang, S, Kostyuchenko, V, Ng, T.-S, Lok, S.-M. 登録日 2016-10-20 公開日 2016-11-30 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (12 Å) 主引用文献 Neutralization mechanism of a highly potent antibody against Zika virus Nat Commun, 7, 2016
5H37	Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C10 IgG heavy chain variable region, C10 IgG light chain variable region, ... 著者 Zhang, S, Kostyuchenko, V, Ng, T.-S, Lim, X.-N, Ooi, J.S.G, Lambert, S, Tan, T.Y, Widman, D, Shi, J, Baric, R.S, Lok, S.-M. 登録日 2016-10-20 公開日 2016-11-30 最終更新日 2022-03-23 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Neutralization mechanism of a highly potent antibody against Zika virus Nat Commun, 7, 2016
5H30	Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 分子名称: IgG C10 heavy chain, IgG C10 light chain, structural protein E, ... 著者 Zhang, S, Kostyuchenko, V, Ng, T.-S, Lok, S.-M. 登録日 2016-10-19 公開日 2016-11-30 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Neutralization mechanism of a highly potent antibody against Zika virus Nat Commun, 7, 2016
5GZN	Structure of neutralizing antibody bound to Zika envelope protein 分子名称: Antibody Heavy chain, Antibody light chain, Genome polyprotein 著者 Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. 登録日 2016-09-29 公開日 2016-12-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
5H9O	Complex of Murine endoplasmic reticulum alpha-glucosidase II with D-Glucose 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Caputo, A.T, Roversi, P, Alonzi, D.S, Kiappes, J.L, Zitzmann, N. 登録日 2015-12-29 公開日 2016-07-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals. Proc.Natl.Acad.Sci.USA, 113, 2016
5HJO	Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue 分子名称: 1,2-ETHANEDIOL, 2-deoxy-alpha-D-arabino-hexopyranose-(1-3)-D-glucal, ACETATE ION, ... 著者 Caputo, A.T, Roversi, P, Alonzi, D.S, Kiappes, J.L, Zitzmann, N. 登録日 2016-01-13 公開日 2016-07-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals. Proc.Natl.Acad.Sci.USA, 113, 2016
5HJR	Murine endoplasmic reticulum alpha-glucosidase II with bound covalent intermediate 分子名称: 1,2-ETHANEDIOL, 5-fluoro-beta-D-glucopyranose, CALCIUM ION, ... 著者 Caputo, A.T, Roversi, P, Alonzi, D.S, Kiappes, J.L, Zitzmann, N. 登録日 2016-01-13 公開日 2016-07-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals. Proc.Natl.Acad.Sci.USA, 113, 2016
5GS6	Full-length NS1 structure of Zika virus from 2015 Brazil strain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, NS1 of Zika virus from 2015 Brazil strain 著者 Xu, X.Y, Song, H, Qi, J.X, Shi, Y, Gao, G.F. 登録日 2016-08-14 公開日 2016-10-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.852 Å) 主引用文献 Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure Embo J., 35, 2016
5GZO	Structure of neutralizing antibody bound to Zika envelope protein 分子名称: Antibody heavy chain, Antibody light chain, Genome polyprotein 著者 Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. 登録日 2016-09-29 公開日 2017-01-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.755 Å) 主引用文献 Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016

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