7L9E

Crystal structure of apo-alpha glucosidase

Summary for 7L9E

• Entry DOI: 10.2210/pdb7l9e/pdb
• Descriptor: Neutral alpha-glucosidase AB Trypsin-cleaved Fragment #1, Neutral alpha-glucosidase AB Trypsin-cleaved Fragment #2, Neutral alpha-glucosidase AB Trypsin-cleaved Fragment #3, ... (10 entities in total)
• Functional Keywords: alpha glucosidase ii, endoplasmic reticulum, hydrolase, inhibitor complex
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 8
• Total formula weight: 235888.54

Authors

Karade, S.S.,Mariuzza, R.A. (deposition date: 2021-01-03, release date: 2021-12-29, Last modification date: 2023-10-18)

• Primary citation: Karade, S.S.,Hill, M.L.,Kiappes, J.L.,Manne, R.,Aakula, B.,Zitzmann, N.,Warfield, K.L.,Treston, A.M.,Mariuzza, R.A.; N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity.; J.Med.Chem., 64:18010-18024, 2021; PubMed: 34870992; DOI: 10.1021/acs.jmedchem.1c01377

Experimental method

X-RAY DIFFRACTION (2.29 Å)