PDB: 658 件ウェブページステータス検索Chemie searchBIRD

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6QEE	Nanodisc reconstituted Human-mouse chimeric ABCB1 (ABCB1HM)-EQ mutant in complex with UIC2 Fab and Zosuquidar. 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ABCB1HM-EQ, ... 著者 Alam, A. 登録日 2019-01-07 公開日 2019-02-27 最終更新日 2021-06-02 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science, 363, 2019
4MT1	Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump 分子名称: Drug efflux protein 著者 Su, C.-C, Bolla, J.R, Yu, E.W. 登録日 2013-09-18 公開日 2014-08-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.54 Å) 主引用文献 Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel. Plos One, 9, 2014
6HBU	Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family G member 2, MAGNESIUM ION 著者 Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P. 登録日 2018-08-13 公開日 2018-11-07 最終更新日 2019-10-23 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature, 563, 2018
6HCO	Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... 著者 Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P. 登録日 2018-08-15 公開日 2018-11-07 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.58 Å) 主引用文献 Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature, 563, 2018
6HZM	Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium (alternative placement of Magnesium into the cryo-EM density) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family G member 2, MAGNESIUM ION 著者 Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P. 登録日 2018-10-23 公開日 2018-11-14 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature, 563, 2018
4PQK	C-Terminal domain of DNA binding protein 分子名称: Maltose ABC transporter periplasmic protein, Truncated replication protein RepA, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Schumacher, M.A, Chinnam, N, Tonthat, N.K. 登録日 2014-03-03 公開日 2014-06-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.401 Å) 主引用文献 Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein. Proc.Natl.Acad.Sci.USA, 111, 2014
4ZZD	CRYSTAL STRUCTURE OF MULTIDRUG RESISTANCE REGULATOR LMRR BOUND TO RIBOFLAVIN 分子名称: RIBOFLAVIN, TRANSCRIPTIONAL REGULATOR, PADR-LIKE FAMILY 著者 Madoori, P.K, Thunnissen, A.-M.W.H. 登録日 2015-05-22 公開日 2015-08-26 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.351 Å) 主引用文献 Binding of the Lactococcal Drug Dependent Transcriptional Regulator LmrR to Its Ligands and Responsive Promoter Regions. Plos One, 10, 2015
5H9T	Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa 分子名称: NalD 著者 Chen, W.Z, Wang, D, Huang, S.Q, Hu, Q.Y, Liu, X.C, Gan, J.H, Chen, H. 登録日 2015-12-29 公開日 2016-04-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa. Mol. Microbiol., 100, 2016
6OF0	Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae 分子名称: HTH-type transcriptional regulator MtrR, PHOSPHATE ION 著者 Beggs, G.A, Kumaraswami, M, Shafer, W, Brennan, R.G. 登録日 2019-03-28 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae . J.Bacteriol., 201, 2019
6TH4	Tubulin-inhibitor complex 分子名称: 1,2,3,9-tetramethoxy-6-methylidene-5~{H}-cyclohepta[a]naphthalen-8-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Varela, P.F, Gigant, B. 登録日 2019-11-18 公開日 2021-12-01 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.121 Å) 主引用文献 B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner Acs Omega, 7, 2022
5DAJ	Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa 分子名称: NalD 著者 Chen, W.Z, Wang, D, Huang, S.Q, Hu, Q.Y, Liu, X.C, Gan, J.H, Chen, H. 登録日 2015-08-20 公開日 2016-04-20 最終更新日 2023-04-12 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa Mol.Microbiol., 100, 2016
3ECH	The MarR-family repressor MexR in complex with its antirepressor ArmR 分子名称: 25-mer fragment of protein ArmR, Multidrug resistance operon repressor 著者 Wilke, M.S, Strynadka, N.C.J. 登録日 2008-08-30 公開日 2008-10-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR Proc.Natl.Acad.Sci.Usa, 105, 2008
7PZF	Crystal structure of the OmpK36 TD insertion chimera from Klebsiella pneumonia 分子名称: LITHIUM ION, OmpK36, TETRADECANE 著者 Kwong, H, Beis, K. 登録日 2021-10-12 公開日 2022-07-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.499 Å) 主引用文献 Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae. Plos Pathog., 18, 2022
7Q3T	Crystal structure of the OmpK36 D insertion chimera from Klebsiella pneumonia 分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, LITHIUM ION, OmpK36 著者 Kwong, H, Beis, K. 登録日 2021-10-28 公開日 2022-07-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.788 Å) 主引用文献 Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae. Plos Pathog., 18, 2022
6P7F	Human ABCC6 NBD2 R1459D mutant in Apo state 分子名称: Multidrug resistance-associated protein 6, SULFATE ION 著者 Zheng, A, Thibodeau, P.H. 登録日 2019-06-05 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.85004 Å) 主引用文献 Structures of human ABCC6 NBD1 and NBD2 To Be Published
4C3Z	Nucleotide-free crystal structure of nucleotide-binding domain 1 from human MRP1 supports a general-base catalysis mechanism for ATP hydrolysis. 分子名称: MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1, SULFATE ION 著者 Chaptal, V, Gueguen-Chaignon, V, Magnard, S, Falson, P, Di Pietro, A, Baubichon-Cortay, H. 登録日 2013-08-28 公開日 2014-09-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Nucleotide-Free Crystal Structure of Nucleotide-Binding Domain 1 from Human Abcc1 Supports a 'General-Base Catalysis' Mechanism for ATP Hydrolysis. Biochem.Pharm., 3, 2014
6NLO	Human ABCC6 NBD1 H812A in Apo state 分子名称: Multidrug resistance-associated protein 6, SULFATE ION 著者 Zheng, A, Thibodeau, P.H. 登録日 2019-01-08 公開日 2020-01-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.85021973 Å) 主引用文献 Structures of human ABCC6 NBD1 and NBD2 To be published
4V1F	Crystal structure of a mycobacterial ATP synthase rotor ring in complex with Bedaquiline 分子名称: Bedaquiline, F0F1 ATP SYNTHASE SUBUNIT C, octyl beta-D-glucopyranoside 著者 Preiss, L, Yildiz, O, Meier, T. 登録日 2014-09-26 公開日 2015-05-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.697 Å) 主引用文献 Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline. Sci Adv, 1, 2015
4V1G	Crystal structure of a mycobacterial ATP synthase rotor ring 分子名称: F0F1 ATP SYNTHASE SUBUNIT C, octyl beta-D-glucopyranoside 著者 Preiss, L, Yildiz, O, Meier, T. 登録日 2014-09-26 公開日 2015-05-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure of the Mycobacterial ATP Synthase Fo Rotor Ring in Complex with the Anti-Tb Drug Bedaquiline. Sci.Adv., 1, 2015
5NSW	Xenon for tunnelling analysis of the efflux pump component OprN. 分子名称: Multidrug efflux outer membrane protein OprN, NICKEL (II) ION, PALMITIC ACID, ... 著者 Phan, G, Prange, T, Enguene Ntsogo, Y.V, Garnier, C, Ducruix, A, Broutin, I. 登録日 2017-04-27 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Xenon for tunnelling analysis of the efflux pump component OprN. PLoS ONE, 12, 2017
3VFJ	The structure of monodechloro-teicoplanin in complex with its ligand, using MBP as a ligand carrier 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose, 8-METHYLNONANOIC ACID, ... 著者 Economou, N.J, Weeks, S.D, Grasty, K.C, Loll, P.J. 登録日 2012-01-09 公開日 2013-01-09 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach. Acta Crystallogr.,Sect.D, 69, 2013
6W0V	The Crystal Structure of the Mutant Nuclease Domain of Pyocin S8 with its Cognate Immunity Protein 分子名称: Bacteriocin immunity protein, Pyocin S8 著者 Turano, H, Gomes, F, Domingos, R.M, Netto, L.E.S. 登録日 2020-03-03 公開日 2020-09-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.381 Å) 主引用文献 Molecular Structure and Functional Analysis of Pyocin S8 from Pseudomonas aeruginosa Reveals the Essential Requirement of a Glutamate Residue in the H-N-H Motif for DNase Activity. J.Bacteriol., 202, 2020
7ZK6	ABCB1 L335C mutant (mABCB1) in the outward facing state bound to 2 molecules of AAC 分子名称: (4S,11S,18S)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Parey, K, Januliene, D, Gewering, T, Moeller, A. 登録日 2022-04-12 公開日 2023-04-26 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Tracing the substrate translocation mechanism in P-glycoprotein. Elife, 12, 2024
7ZKA	ABCB1 V978C mutant (mABCB1) in the outward facing state bound to AAC 分子名称: (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, ... 著者 Parey, K, Januliene, D, Gewering, T, Urbatsch, I, Zhang, Q, Moeller, A. 登録日 2022-04-12 公開日 2023-04-26 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Tracing the substrate translocation mechanism in P-glycoprotein. Elife, 12, 2024
7ZK9	ABCB1 L971C mutant (mABCB1) in the inward facing state 分子名称: (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ATP-dependent translocase ABCB1 著者 Parey, K, Januliene, D, Gewering, T, Zhang, Q, Moeller, A. 登録日 2022-04-12 公開日 2023-04-26 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Tracing the substrate translocation mechanism in P-glycoprotein. Elife, 12, 2024

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