6QEE
Nanodisc reconstituted Human-mouse chimeric ABCB1 (ABCB1HM)-EQ mutant in complex with UIC2 Fab and Zosuquidar.
Summary for 6QEE
| Entry DOI | 10.2210/pdb6qee/pdb |
| EMDB information | 4536 |
| Descriptor | ABCB1HM-EQ, UIC2 Antigen Binding Fragment Light chain, UIC2 Antigen Binding Fragment Heavy Chain, ... (7 entities in total) |
| Functional Keywords | abcb1, p-glycoprotein, p-gp, multidrug transporter, abc transporter, zosuquidar, membrane transporter, membrane protein |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 3 |
| Total formula weight | 197503.62 |
| Authors | Alam, A. (deposition date: 2019-01-07, release date: 2019-02-27, Last modification date: 2021-06-02) |
| Primary citation | Alam, A.,Kowal, J.,Broude, E.,Roninson, I.,Locher, K.P. Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science, 363:753-756, 2019 Cited by PubMed: 30765569DOI: 10.1126/science.aav7102 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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