PDB: 486 件ウェブページステータス検索Chemie searchBIRD

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1T40	Crystal structure of human aldose reductase complexed with NADP and IDD552 at ph 5 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC ACID 著者 Ruiz, F, Hazemann, I, Mitschler, A, Chevrier, B, Schneider, T, Joachimiak, A, Karplus, M, Podjarny, A. 登録日 2004-04-28 公開日 2004-08-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48. Acta Crystallogr.,Sect.D, 60, 2004
1SM9	Crystal Structure Of An Engineered K274RN276D Double Mutant of Xylose Reductase From Candida Tenuis Optimized To Utilize NAD 分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, xylose reductase 著者 Petschacher, B, Leitgeb, S, Kavanagh, K.L, Wilson, D.K, Nidetzky, B. 登録日 2004-03-08 公開日 2004-12-21 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography. Biochem.J., 385, 2005
1VBJ	The crystal structure of prostaglandin F synthase from Trypanosoma brucei 分子名称: CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, prostaglandin F synthase 著者 Inoue, T. 登録日 2004-02-27 公開日 2005-04-12 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The crystal structure of prostaglandin F synthase from Trypanosoma brucei TO BE PUBLISHED
1S2A	Crystal structures of prostaglandin D2 11-ketoreductase in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin 分子名称: Aldo-keto reductase family 1 member C3, DIMETHYL SULFOXIDE, INDOMETHACIN, ... 著者 Lovering, A.L, Ride, J.P, Bunce, C.M, Desmond, J.C, Cummings, S.M, White, S.A. 登録日 2004-01-08 公開日 2004-03-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res., 64, 2004
1S2C	Crystal structures of prostaglandin D2 11-ketoreductase in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin 分子名称: 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Aldo-keto reductase family 1 member C3, DIMETHYL SULFOXIDE, ... 著者 Lovering, A.L, Ride, J.P, Bunce, C.M, Desmond, J.C, Cummings, S.M, White, S.A. 登録日 2004-01-08 公開日 2004-03-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res., 64, 2004
1S1R	Crystal structures of prostaglandin D2 11-ketoreductase (AKR1C3) in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Aldo-keto reductase family 1 member C3, ... 著者 Lovering, A.L, Ride, J.P, Bunce, C.M, Desmond, J.C, Cummings, S.M, White, S.A. 登録日 2004-01-07 公開日 2004-03-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res., 64, 2004
1S1P	Crystal structures of prostaglandin D2 11-ketoreductase (AKR1C3) in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Aldo-keto reductase family 1 member C3, ... 著者 Lovering, A.L, Ride, J.P, Bunce, C.M, Desmond, J.C, Cummings, S.M, White, S.A. 登録日 2004-01-07 公開日 2004-03-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res., 64, 2004
1RY8	Prostaglandin F synthase complexed with NADPH and rutin 分子名称: Aldo-keto reductase family 1 member C3, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RUTIN 著者 Komoto, J, Yamada, T, Watanabe, K, Takusagawa, F. 登録日 2003-12-19 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Crystal structure of human prostaglandin F synthase (AKR1C3). Biochemistry, 43, 2004
1RY0	Structure of prostaglandin F synthase with prostaglandin D2 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROSTAGLANDIN D2 著者 Komoto, J, Yamada, T, Watanabe, K, Takusagawa, F. 登録日 2003-12-19 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Crystal structure of human prostaglandin F synthase (AKR1C3). Biochemistry, 43, 2004
1US0	Human Aldose Reductase in complex with NADP+ and the inhibitor IDD594 at 0.66 Angstrom 分子名称: ALDOSE REDUCTASE, CITRIC ACID, IDD594, ... 著者 Howard, E.I, Sanishvili, R, Cachau, R.E, Mitschler, A, Chevrier, B, Barth, P, Lamour, V, Van Zandt, M, Sibley, E, Bon, C, Moras, D, Schneider, T.R, Joachimiak, A, Podjarny, A. 登録日 2003-11-16 公開日 2004-05-07 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (0.66 Å) 主引用文献 Ultrahigh Resolution Drug Design I: Details of Interactions in Human Aldose Reductase-Inhibitor Complex at 0.66 A. Proteins, 55, 2004
1UR3	Crystal structure of the apo form of the E.coli ydhF protein 分子名称: HYPOTHETICAL OXIDOREDUCTASE YDHF, SULFATE ION 著者 Jeudy, S, Claverie, J.M, Abergel, C. 登録日 2003-10-24 公開日 2003-12-04 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Crystal Structure of Ydhf the E.Coli Aldo-Keto Reductase Ydhf To be Published
1R38	Crystal structure of H114A mutant of Candida tenuis xylose reductase 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, xylose reductase 著者 Kratzer, R, Kavanagh, K.L, Wilson, D.K, Nidetzky, B. 登録日 2003-09-30 公開日 2004-10-12 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Studies of the enzymic mechanism of Candida tenuis xylose reductase (AKR 2B5): X-ray structure and catalytic reaction profile for the H113A mutant Biochemistry, 43, 2004
1QWK	Structural genomics of Caenorhabditis Elegans: Hypothetical 35.2 kDa protein (aldose reductase family member) 分子名称: aldo-keto reductase family 1 member C1 著者 Chen, L, Zhou, X.E, Meehan, E.J, Symersky, J, Lu, S, Li, S, Luo, M, Southeast Collaboratory for Structural Genomics (SECSG) 登録日 2003-09-02 公開日 2003-09-16 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural genomics of Caenorhabditis Elegans: Hypothetical 35.2 kDa protein (aldose reductase family member) To be published
1Q5M	Binary complex of rabbit 20alpha-hydroxysteroid dehydrogenase with NADPH 分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION 著者 Couture, J.F, Legrand, P, Cantin, L, Labrie, F, Luu-The, V, Breton, R. 登録日 2003-08-08 公開日 2004-05-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Loop Relaxation, A Mechanism that Explains the Reduced Specificity of Rabbit 20alpha-Hydroxysteroid Dehydrogenase, A Member of the Aldo-Keto Reductase Superfamily. J.Mol.Biol., 339, 2004
1Q13	Crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with NADP and testosterone 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION, ... 著者 Couture, J.-F, Cantin, L, Legrand, P, Luu-The, V, Labrie, F, Breton, R. 登録日 2003-07-18 公開日 2004-11-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. J. Mol. Biol., 339, 2004
1PZ1	Structure of NADPH-dependent family 11 aldo-keto reductase AKR11B(holo) 分子名称: General stress protein 69, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Ehrensberger, A.H, Wilson, D.K. 登録日 2003-07-09 公開日 2004-03-30 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and Catalytic Diversity in the Two Family 11 Aldo-keto Reductases J.Mol.Biol., 337, 2004
1PZ0	Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(holo) 分子名称: IolS protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION 著者 Ehrensberger, A.H, Wilson, D.K. 登録日 2003-07-09 公開日 2004-03-30 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural and Catalytic Diversity in the Two Family 11 Aldo-keto Reductases J.Mol.Biol., 337, 2004
1PYF	Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(apo) 分子名称: 1,2-ETHANEDIOL, IolS protein, SODIUM ION 著者 Ehrensberger, A.H, Wilson, D.K. 登録日 2003-07-08 公開日 2004-03-23 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and Catalytic Diversity in the Two Family 11 Aldo-keto Reductases J.Mol.Biol., 337, 2004
1PWL	Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat 分子名称: 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, aldose reductase 著者 El-Kabbani, O, Darmanin, C, Schneider, T.R, Hazemann, I, Ruiz, F, Oka, M, Joachimiak, A, Schulze-Briese, C, Tomizaki, T, Mitschler, A, Podjarny, A. 登録日 2003-07-02 公開日 2004-02-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors PROTEINS, 55, 2004
1PWM	Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat 分子名称: (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 El-Kabbani, O, Darmanin, C, Schneider, T.R, Hazemann, I, Ruiz, F, Oka, M, Joachimiak, A, Schulze-Briese, C, Tomizaki, T, Mitschler, A, Podjarny, A. 登録日 2003-07-02 公開日 2004-02-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (0.92 Å) 主引用文献 Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors PROTEINS, 55, 2004
1OG6	ydhF, an aldo-keto reductase from E.coli complexed with NADPH 分子名称: HYPOTHETICAL OXIDOREDUCTASE YDHF, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Jeudy, S, Abergel, C, Claverie, J.M. 登録日 2003-04-24 公開日 2003-05-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of Ydhf, an Aldo-Keto Reductase from Escherichia Coli To be Published
1MZR	Structure of dkga from E.coli at 2.13 A resolution solved by molecular replacement 分子名称: 2,5-diketo-D-gluconate reductase A, GLYCEROL, PHOSPHATE ION 著者 Abergel, C, Jeudy, S, Monchois, V, Claverie, J.M, Bacterial targets at IGS-CNRS, France (BIGS) 登録日 2002-10-09 公開日 2003-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Crystal structure of Escherichia coli DkgA, a broad-specificity aldo-keto reductase. Proteins, 62, 2006
1MRQ	Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone 分子名称: Aldo-keto reductase family 1 member C1, BETA-MERCAPTOETHANOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Couture, J.F, Legrand, P, Cantin, L, Luu-The, V, Labrie, F, Breton, R. 登録日 2002-09-18 公開日 2003-09-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. J.Mol.Biol., 331, 2003
1MI3	1.8 Angstrom structure of xylose reductase from Candida tenuis in complex with NAD 分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, xylose reductase 著者 Kavanagh, K.L, Klimacek, M, Nidetzky, B, Wilson, D.K. 登録日 2002-08-21 公開日 2003-08-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases Biochem.J., 373, 2003
1M9H	Corynebacterium 2,5-DKGR A and Phe 22 replaced with Tyr (F22Y), Lys 232 replaced with Gly (K232G), Arg 238 replaced with His (R238H)and Ala 272 replaced with Gly (A272G)in presence of NADH cofactor 分子名称: 2,5-diketo-D-gluconic acid reductase A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION 著者 Sanli, G, Blaber, M. 登録日 2002-07-29 公開日 2003-08-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural alteration of cofactor specificity in Corynebacterium 2,5-diketo-D-gluconic acid reductase Protein Sci., 13, 2004

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