1T40

Crystal structure of human aldose reductase complexed with NADP and IDD552 at ph 5

Summary for 1T40

• Entry DOI: 10.2210/pdb1t40/pdb
• Related: 1T41
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC ACID, ... (4 entities in total)
• Functional Keywords: aldose reductase, ternary complex, inhibitor binding, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 37056.08

Authors

Ruiz, F.,Hazemann, I.,Mitschler, A.,Chevrier, B.,Schneider, T.,Joachimiak, A.,Karplus, M.,Podjarny, A. (deposition date: 2004-04-28, release date: 2004-08-03, Last modification date: 2024-03-13)

• Primary citation: Ruiz, F.,Hazemann, I.,Mitschler, A.,Joachimiak, A.,Schneider, T.,Karplus, M.,Podjarny, A.; The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.; Acta Crystallogr.,Sect.D, 60:1347-1354, 2004; PubMed: 15272156; DOI: 10.1107/S0907444904011370

Experimental method

X-RAY DIFFRACTION (1.8 Å)