1S1R

Crystal structures of prostaglandin D2 11-ketoreductase (AKR1C3) in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin

Summary for 1S1R

Entry DOI	10.2210/pdb1s1r/pdb
Related	1S1P 1S2A 1S2C
Descriptor	Aldo-keto reductase family 1 member C3, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	tim-barrel, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P42330
Total number of polymer chains	1
Total formula weight	38887.98
Authors	Lovering, A.L.,Ride, J.P.,Bunce, C.M.,Desmond, J.C.,Cummings, S.M.,White, S.A. (deposition date: 2004-01-07, release date: 2004-03-23, Last modification date: 2023-10-25)
Primary citation	Lovering, A.L.,Ride, J.P.,Bunce, C.M.,Desmond, J.C.,Cummings, S.M.,White, S.A. Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res., 64:1802-1810, 2004 Cited by PubMed: 14996743 DOI: 10.1158/0008-5472.CAN-03-2847 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation