1S2A
Crystal structures of prostaglandin D2 11-ketoreductase in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin
Summary for 1S2A
Entry DOI | 10.2210/pdb1s2a/pdb |
Related | 1S1P 1S1R 1S2C |
Descriptor | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, INDOMETHACIN, ... (6 entities in total) |
Functional Keywords | tim-barrel, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P42330 |
Total number of polymer chains | 1 |
Total formula weight | 39146.68 |
Authors | Lovering, A.L.,Ride, J.P.,Bunce, C.M.,Desmond, J.C.,Cummings, S.M.,White, S.A. (deposition date: 2004-01-08, release date: 2004-03-23, Last modification date: 2023-10-25) |
Primary citation | Lovering, A.L.,Ride, J.P.,Bunce, C.M.,Desmond, J.C.,Cummings, S.M.,White, S.A. Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res., 64:1802-1810, 2004 Cited by PubMed: 14996743DOI: 10.1158/0008-5472.CAN-03-2847 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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