1US0
Human Aldose Reductase in complex with NADP+ and the inhibitor IDD594 at 0.66 Angstrom
Summary for 1US0
Entry DOI | 10.2210/pdb1us0/pdb |
Related | 1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 2ACQ 2ACR 2ACS 2ACU |
Descriptor | ALDOSE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ... (5 entities in total) |
Functional Keywords | oxidoreductase, nadp, idd594 |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 37444.25 |
Authors | Howard, E.I.,Sanishvili, R.,Cachau, R.E.,Mitschler, A.,Chevrier, B.,Barth, P.,Lamour, V.,Van Zandt, M.,Sibley, E.,Bon, C.,Moras, D.,Schneider, T.R.,Joachimiak, A.,Podjarny, A. (deposition date: 2003-11-16, release date: 2004-05-07, Last modification date: 2024-05-08) |
Primary citation | Howard, E.I.,Sanishvili, R.,Cachau, R.E.,Mitschler, A.,Chevrier, B.,Barth, P.,Lamour, V.,Van Zandt, M.,Sibley, E.,Bon, C.,Moras, D.,Schneider, T.R.,Joachimiak, A.,Podjarny, A. Ultrahigh Resolution Drug Design I: Details of Interactions in Human Aldose Reductase-Inhibitor Complex at 0.66 A. Proteins, 55:792-, 2004 Cited by PubMed: 15146478DOI: 10.1002/PROT.20015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.66 Å) |
Structure validation
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