1AZ1

ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE

Summary for 1AZ1

Entry DOI	10.2210/pdb1az1/pdb
Descriptor	ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ALRESTATIN, ... (4 entities in total)
Functional Keywords	oxidoreductase, aldo-keto reductase, inhibitor binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	36965.90
Authors	Harrison, D.H.T.,Bohren, K.M.,Petsko, G.A.,Ringe, D.,Gabbay, K.H. (deposition date: 1997-11-24, release date: 1998-03-18, Last modification date: 2023-08-02)
Primary citation	Harrison, D.H.,Bohren, K.M.,Petsko, G.A.,Ringe, D.,Gabbay, K.H. The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. Biochemistry, 36:16134-16140, 1997 Cited by PubMed: 9405046 DOI: 10.1021/bi9717136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation