1AZ1
ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | ALDOSE REDUCTASE | polymer | 315 | 35712.0 | 1 | UniProt (P15121) Pfam (PF00248) In PDB | Homo sapiens (human) | |
2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | A | ALRESTATIN | non-polymer | 255.2 | 2 | Chemie (ALR) | |||
4 | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A: 1 - 315 (UniProt: P15121)
PDB | External Database | Details |
---|---|---|
Tyr 219 | Trp 219 | engineered mutation |
Ala 298 | Cys 298 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35712.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1253.9 | |
All* | Total formula weight | 36965.9 |