1MAR

REFINED 1.8 ANGSTROMS STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE POTENT INHIBITOR ZOPOLRESTAT

Summary for 1MAR

Entry DOI	10.2210/pdb1mar/pdb
Descriptor	ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID (3 entities in total)
Functional Keywords	oxidoreductase(nadp)
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	36929.93
Authors	Wilson, D.K.,Quiocho, F.A. (deposition date: 1993-07-20, release date: 1995-07-20, Last modification date: 2024-02-14)
Primary citation	Wilson, D.K.,Tarle, I.,Petrash, J.M.,Quiocho, F.A. Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat. Proc.Natl.Acad.Sci.USA, 90:9847-9851, 1993 Cited by PubMed: 8234324 DOI: 10.1073/pnas.90.21.9847 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation