PDB: 19040 件ウェブページステータス検索Chemie searchBIRD

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3ALN	Crystal Structure of human non-phosphorylated MKK4 kinase domain complexed with AMP-PNP 分子名称: Dual specificity mitogen-activated protein kinase kinase 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Matsumoto, T, Kinoshita, T, Kirii, Y, Yokota, K, Hamada, K, Tada, T. 登録日 2010-08-04 公開日 2010-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state Biochem.Biophys.Res.Commun., 400, 2010
4E1I	Fragment of human prion protein 分子名称: Major prion protein 著者 Apostol, M.I, Surewicz, W.K. 登録日 2012-03-06 公開日 2013-03-06 最終更新日 2013-11-27 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Crystal structure of a human prion protein fragment reveals a motif for oligomer formation. J.Am.Chem.Soc., 135, 2013
4E4E	Crystal Structure of the Y34F mutant of Saccharomyces cerevisiae Manganese Superoxide Dismutase 分子名称: MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial 著者 Sheng, Y, Cascio, D, Valentine, J.S. 登録日 2012-03-12 公開日 2012-08-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Six-coordinate manganese(3+) in catalysis by yeast manganese superoxide dismutase. Proc.Natl.Acad.Sci.USA, 109, 2012
4EG6	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1325 分子名称: 4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(2-chloro-4-methoxyphenoxy)pyrimidin-2-yl}piperazin-2-one, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2012-03-30 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection. Structure, 20, 2012
4E6I	Crystal structure of Staphylococcal nuclease variant NVIAGA V99G at cryogenic temperature 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, Thermonuclease 著者 Doctrow, B.M, Schlessman, J.L, Garcia-Moreno E, B. 登録日 2012-03-15 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Local flexibility as a determinant of pKa values of surface ionizable groups in proteins To be Published
4E96	Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1 分子名称: 1,2-ETHANEDIOL, 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide, Bromodomain-containing protein 4, ... 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Fish, P, Bunnage, M, Owen, D, Knapp, S, Cook, A, Structural Genomics Consortium (SGC) 登録日 2012-03-20 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J.Med.Chem., 55, 2012
4EAN	1.75A resolution structure of indole bound beta-glycosidase (W33G) from sulfolobus solfataricus 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-galactosidase, CHLORIDE ION, ... 著者 Lovell, S, Battaile, K.P, Deckert, K, Brunner, L.C, Budiardjo, S.J, Karanicolas, J. 登録日 2012-03-22 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Designing allosteric control into enzymes by chemical rescue of structure. J.Am.Chem.Soc., 134, 2012
4EGG	Computationally Designed Self-assembling tetrahedron protein, T310 分子名称: GLYCEROL, Putative acetyltransferase SACOL2570 著者 Sawaya, M.R, King, N.P, Sheffler, W, Baker, D, Yeates, T.O. 登録日 2012-03-30 公開日 2012-05-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science, 336, 2012
4E4T	Crystal structure of Phosphoribosylaminoimidazole carboxylase, ATPase subunit from Burkholderia ambifaria 分子名称: Phosphoribosylaminoimidazole carboxylase, ATPase subunit, SULFATE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-03-13 公開日 2012-03-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
4DEF	Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from M. tuberculosis 分子名称: ACETATE ION, Fructose-bisphosphate aldolase, SODIUM ION, ... 著者 Capodagli, G.C, Pegan, S.D. 登録日 2012-01-20 公開日 2013-01-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Biochemistry, 52, 2013
4DJT	Crystal structure of a nuclear GTP-binding protein from Encephalitozoon cuniculi bound to GDP-Mg2+ 分子名称: GTP-binding nuclear protein GSP1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-02-02 公開日 2012-02-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of a nuclear GTP-binding protein from Encephalitozoon cuniculi bound to GDP-Mg2+ To be Published
4DK3	Structure of Editosome protein 分子名称: RNA-editing complex protein MP81, single domain antibody VHH 著者 Park, Y.-J, Hol, W. 登録日 2012-02-03 公開日 2012-07-04 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2. Nucleic Acids Res., 40, 2012
4DKA	Structure of Editosome protein 分子名称: RNA-editing complex protein MP81, SODIUM ION, single domain antibody VHH 著者 Park, Y.-J, Hol, W. 登録日 2012-02-03 公開日 2012-07-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2. Nucleic Acids Res., 40, 2012
4DOJ	Crystal structure of BetP in outward-facing conformation 分子名称: (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, CHLORIDE ION, CHOLINE ION, ... 著者 Perez, C, Ziegler, C. 登録日 2012-02-09 公開日 2012-06-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP. Nature, 490, 2012
4DPF	BACE-1 in complex with a HEA-macrocyclic type inhibitor 分子名称: Beta-secretase 1, N-[(4S,8E,11S)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl]-N-methylmethanesulfonamide 著者 Lindberg, J, Borkakoti, N, Derbyshire, D. 登録日 2012-02-13 公開日 2012-07-11 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes. Bioorg.Med.Chem., 20, 2012
4DX2	Crystal structure of the human TRPV4 ankyrin repeat domain 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Transient receptor potential cation channel subfamily V member 4, ... 著者 Inada, H, Gaudet, R. 登録日 2012-02-27 公開日 2012-07-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry, 51, 2012
4DI0	The structure of Rubrerythrin from Burkholderia pseudomallei 分子名称: 1,2-ETHANEDIOL, FE (III) ION, GLYCEROL, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-01-30 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The structure of Rubrerythrin from Burkholderia pseudomallei TO BE PUBLISHED
4DIE	Crystal structure of a cytidylate kinase CmK from Mycobacterium abscessus bound to cytidine-5'-monophosphate 分子名称: CYTIDINE-5'-MONOPHOSPHATE, Cytidylate kinase, PHOSPHATE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-01-30 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4DI8	CRYSTAL STRUCTURE OF THE D248A mutant of 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE FROM SPHINGOMONAS PAUCIMOBILIS complexed with substrate at pH 8.5 分子名称: (1E,3Z)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylic acid, 2-oxo-2H-pyran-4,6-dicarboxylic acid, 2-pyrone-4,6-dicarbaxylate hydrolase, ... 著者 Malashkevich, V.N, Toro, R, Hobbs, M.E, Raushel, F.M, Almo, S.C. 登録日 2012-01-11 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation. Biochemistry, 51, 2012
4DYW	Crystal structure of MutT NUDIX hydrolase from Burkholderia pseudomallei 分子名称: MutT/NUDIX family protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-02-29 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of MutT NUDIX hydrolase from Burkholderia pseudomallei To be Published
4E0O	SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form III) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION 著者 Zhao, M, Liu, C, Sawaya, M.R, Eisenberg, D. 登録日 2012-03-04 公開日 2012-12-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109, 2012
4DK6	Structure of Editosome protein 分子名称: RNA-editing complex protein MP81, single domain antibody VHH 著者 Park, Y.-J, Hol, W. 登録日 2012-02-03 公開日 2012-07-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2. Nucleic Acids Res., 40, 2012
4DNQ	Crystal Structure of DAD2 S96A mutant 分子名称: DAD2 著者 Hamiaux, C. 登録日 2012-02-08 公開日 2012-11-14 最終更新日 2013-06-26 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 DAD2 Is an alpha/beta Hydrolase likely to Be Involved in the Perception of the Plant Branching Hormone, Strigolactone Curr.Biol., 22, 2012
4DI9	CRYSTAL STRUCTURE OF THE D248A mutant of 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE FROM SPHINGOMONAS PAUCIMOBILIS complexed with substrate at pH 6.5 分子名称: (1E,3Z)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylic acid, 2-pyrone-4,6-dicarbaxylate hydrolase, ACETATE ION 著者 Malashkevich, V.N, Toro, R, Hobbs, M.E, Raushel, F.M, Almo, S.C. 登録日 2012-01-11 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation. Biochemistry, 51, 2012
4DON	Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon 分子名称: 3-methyl-3,4-dihydroquinazolin-2(1H)-one, Bromodomain-containing protein 4 著者 Xiong, B, Cao, D.Y, Chen, W.Y, Chen, T.T, Xu, Y.C, Shen, J.K. 登録日 2012-02-09 公開日 2013-02-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon To be Published

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