3ALN

Crystal Structure of human non-phosphorylated MKK4 kinase domain complexed with AMP-PNP

Summary for 3ALN

• Entry DOI: 10.2210/pdb3aln/pdb
• Related: 3ALO
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION (3 entities in total)
• Functional Keywords: kinase, protein amp-pnp complex, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P45985
• Total number of polymer chains: 3
• Total formula weight: 113980.19

Authors

Matsumoto, T.,Kinoshita, T.,Kirii, Y.,Yokota, K.,Hamada, K.,Tada, T. (deposition date: 2010-08-04, release date: 2010-10-27, Last modification date: 2023-11-01)

• Primary citation: Matsumoto, T.,Kinoshita, T.,Kirii, Y.,Yokota, K.,Hamada, K.,Tada, T.; Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state; Biochem.Biophys.Res.Commun., 400:369-373, 2010; PubMed: 20732303; DOI: 10.1016/j.bbrc.2010.08.071

Experimental method

X-RAY DIFFRACTION (2.3 Å)