3ALO
Crystal structure of human non-phosphorylated MKK4 kinase domain ternary complex with AMP-PNP and p38 peptide
Summary for 3ALO
Entry DOI | 10.2210/pdb3alo/pdb |
Related | 3ALN |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 4, p38 peptide, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kinase, allosteric binding, activation helix, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : P45985 |
Total number of polymer chains | 2 |
Total formula weight | 38982.39 |
Authors | Matsumoto, T.,Kinoshita, T.,Kirii, Y.,Yokota, K.,Hamada, K.,Tada, T. (deposition date: 2010-08-04, release date: 2010-10-27, Last modification date: 2023-11-01) |
Primary citation | Matsumoto, T.,Kinoshita, T.,Kirii, Y.,Yokota, K.,Hamada, K.,Tada, T. Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state Biochem.Biophys.Res.Commun., 400:369-373, 2010 Cited by PubMed: 20732303DOI: 10.1016/j.bbrc.2010.08.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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