PDB: 82203 件ウェブページステータス検索Chemie searchBIRD

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5AL2	Crystal structure of TNKS2 in complex with 2-(4-(propan-2-yl)phenyl)- 1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one 分子名称: (2S)-2-(4-propan-2-ylphenyl)-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Lehtio, L. 登録日 2015-03-06 公開日 2015-07-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Potent and Selective Nonplanar Tankyrase Inhibiting Nicotinamide Mimics. Bioorg.Med.Chem., 23, 2015
2JH7	Crystal structure of Toxoplasma gondii micronemal protein 1 bound to 6'-sialyl-N-acetyllactosamine 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Blumenschein, T.M.A, Friedrich, N, Childs, R.A, Saouros, S, Carpenter, E.P, Campanero-Rhodes, M.A, Simpson, P, Koutroukides, T, Blackman, M.J, Feizi, T, Soldati-Favre, D, Matthews, S. 登録日 2007-02-20 公開日 2007-05-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Atomic Resolution Insight Into Host Cell Recognition by Toxoplasma Gondii. Embo J., 26, 2007
4YPS	(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors 分子名称: 4-{6-[(3R)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile, High affinity nerve growth factor receptor, SULFATE ION 著者 Kreusch, A, Rucker, P, Molteni, V, Loren, J. 登録日 2015-03-13 公開日 2015-06-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1012 Å) 主引用文献 (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. Acs Med.Chem.Lett., 6, 2015
2JH1	Crystal structure of Toxoplasma gondii micronemal protein 1 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Blumenschein, T.M.A, Friedrich, N, Childs, R.A, Saouros, S, Carpenter, E.P, Campanero-Rhodes, M.A, Simpson, P, Koutroukides, T, Blackman, M.J, Feizi, T, Soldati-Favre, D, Matthews, S. 登録日 2007-02-19 公開日 2007-05-22 最終更新日 2019-01-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Atomic Resolution Insight Into Host Cell Recognition by Toxoplasma Gondii. Embo J., 26, 2007
6ISU	Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein UCHL3 分子名称: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L3 著者 Ding, S, Pan, M, Zheng, Q, Ren, Y, Hong, D. 登録日 2018-11-19 公開日 2019-02-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.866 Å) 主引用文献 Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains. Angew. Chem. Int. Ed. Engl., 58, 2019
7OTR	Crystal structure of a psychrophilic CCA-adding enzyme determined by SAD phasing 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CCA-adding protein, ... 著者 Rollet, K, de Wijn, R, Rios-Santacruz, R, Hennig, O, Betat, H, Moerl, M, Sauter, C. 登録日 2021-06-10 公開日 2021-11-03 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 CCA-addition in the cold: Structural characterization of the psychrophilic CCA-adding enzyme from the permafrost bacterium Planococcus halocryophilus . Comput Struct Biotechnol J, 19, 2021
6WQ9	Carbonic Anhydrase II Complexed with 3-((2-((Naphthalen-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, GLYCEROL, ... 著者 Andring, J.T, Combs, J.E, Lomelino, C, McKenna, R. 登録日 2020-04-28 公開日 2020-06-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.305 Å) 主引用文献 Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. J.Med.Chem., 63, 2020
6WQ8	Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, GLYCEROL, ... 著者 Andring, J.T, Combs, J.E, Lomelino, C, McKenna, R. 登録日 2020-04-28 公開日 2020-06-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.405 Å) 主引用文献 Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. J.Med.Chem., 63, 2020
6GJD	Erk2 signalling protein 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 1, ... 著者 O'Reilly, M. 登録日 2018-05-16 公開日 2019-01-02 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe. Chem Sci, 9, 2018
6UUP	Structure of anti-hCD33 conditional scFv 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Anti-CD33 conditional scFv, DI(HYDROXYETHYL)ETHER, ... 著者 Kimberlin, C.R, Park, S. 登録日 2019-10-31 公開日 2020-11-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.20001864 Å) 主引用文献 Direct control of CAR T cells through small molecule-regulated antibodies. Nat Commun, 12, 2021
4P7B	Crystal structure of S. typhimurium peptidyl-tRNA hydrolase 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Peptidyl-tRNA hydrolase 著者 Vandavasi, V.G, McFeeters, R.L, Taylor-Creel, K, Coates, L, McFeeters, H. 登録日 2014-03-26 公開日 2014-07-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Recombinant production, crystallization and X-ray crystallographic structure determination of peptidyl-tRNA hydrolase from Salmonella typhimurium. Acta Crystallogr.,Sect.F, 70, 2014
4ZT8	Structure of the complex of type 1 ribosome inactivating protein from Momordica balsamina with a pyrimidine base, cytosine at 1.98 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINOPYRIMIDIN-2(1H)-ONE, GLYCEROL, ... 著者 Yamini, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P. 登録日 2015-05-14 公開日 2015-06-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Binding and structural studies of the complexes of type 1 ribosome inactivating protein fromMomordica balsaminawith cytosine, cytidine, and cytidine diphosphate. Biochem Biophys Rep, 4, 2015
4ZU0	Structure of the complex of type 1 ribosome inactivating protein from Momordica balsamina with a nucleotide, cytidine monophosphate at 1.80 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-MONOPHOSPHATE, GLYCEROL, ... 著者 Yamin, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P. 登録日 2015-05-15 公開日 2015-06-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Binding and structural studies of the complexes of type 1 ribosome inactivating protein fromMomordica balsaminawith cytosine, cytidine, and cytidine diphosphate. Biochem Biophys Rep, 4, 2015
7QSM	Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... 著者 Chung, I, Bridges, H.R, Hirst, J. 登録日 2022-01-13 公開日 2022-05-25 最終更新日 2022-09-28 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
8DQU	Nanobody bound SARS-CoV-2 Nsp9 分子名称: Nanobody, Non-structural protein 9 著者 Littler, D.R, Gully, B.S, Rossjohn, J. 登録日 2022-07-20 公開日 2023-02-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.45003176 Å) 主引用文献 Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9. Plos One, 18, 2023
8BDW	Crystal structure of CnaB2 domain from Lactobacillus plantarum 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell surface adherence protein,collagen-binding domain, LPXTG-motif cell wall anchor, ... 著者 Taberman, H, Hakanpaa, J, Linder, M.B, Aranko, A.S. 登録日 2022-10-20 公開日 2023-02-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Biomolecular Click Reactions Using a Minimal pH-Activated Catcher/Tag Pair for Producing Native-Sized Spider-Silk Proteins. Angew.Chem.Int.Ed.Engl., 62, 2023
8ONV	KRAS-G13D in complex with BI-2493 分子名称: (7~{S})-2'-azanyl-3-[2-[(2~{S})-2-methylpiperazin-1-yl]pyrimidin-4-yl]spiro[5,6-dihydro-4~{H}-1,2-benzoxazole-7,4'-6,7-dihydro-5~{H}-1-benzothiophene]-3'-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... 著者 Boettcher, J, Herdeis, L. 登録日 2023-04-04 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.01 Å) 主引用文献 Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
4GE1	Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus 分子名称: 2-(1H-INDOL-3-YL)ETHANAMINE, Biogenic amine-binding protein, GLYCEROL 著者 Andersen, J.F, Chang, B.W, Xu, X, Mans, B.J, Ribeiro, J.M. 登録日 2012-08-01 公開日 2013-01-02 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi. Acta Crystallogr.,Sect.D, 69, 2013
1P2Q	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Chymotrypsinogen A, Pancreatic trypsin inhibitor, ... 著者 Helland, R, Czapinska, H, Leiros, I, Olufsen, M, Otlewski, J, Smalaas, A.O. 登録日 2003-04-15 公開日 2004-04-20 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin. J.Mol.Biol., 333, 2003
4TQI	Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode 分子名称: (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, Transthyretin 著者 Stura, E.A, Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E. 登録日 2014-06-11 公開日 2015-06-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
4PHC	Crystal Structure of a human cytosolic histidyl-tRNA synthetase, histidine-bound 分子名称: GLYCEROL, HISTIDINE, Histidine--tRNA ligase, ... 著者 Koh, C.Y, Wetzel, A.B, de van der Schueren, W.J, Hol, W.G.J. 登録日 2014-05-06 公開日 2014-08-27 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.844 Å) 主引用文献 Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases. Biochimie, 106, 2014
2JCA	Crystal structure of the streptomyces coelicolor holo- [Acyl-carrier-protein] Synthase (AcpS) at 2 A. 分子名称: GLYCEROL, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, SODIUM ION, ... 著者 Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. 登録日 2006-12-21 公開日 2007-01-30 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity. Biochemistry, 50, 2011
4EM9	Human PPAR gamma in complex with nonanoic acids 分子名称: 3,3',3''-phosphanetriyltripropanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma, ... 著者 Liberato, M.V, Nascimento, A.S, Polikarpov, I. 登録日 2012-04-11 公開日 2013-03-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists Plos One, 7, 2012
2JJQ	The crystal structure of Pyrococcus abyssi tRNA (uracil-54, C5)- methyltransferase in complex with S-adenosyl-L-homocysteine 分子名称: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, UNCHARACTERIZED RNA METHYLTRANSFERASE PYRAB10780 著者 Walbott, H, Leulliot, N, Grosjean, H, Golinelli-Pimpaneau, B. 登録日 2008-04-17 公開日 2008-08-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Crystal Structure of Pyrococcus Abyssi tRNA (Uracil-54, C5)-Methyltransferase Provides Insights Into its tRNA Specificity. Nucleic Acids Res., 36, 2008
6TER	Crystal structure of a galactokinase from Bifidobacterium infantis in complex with Galactose 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Keenan, T, Parmeggiani, F, Fontenelle, C.Q, Malassis, J, Vendeville, J, Offen, W.A, Both, P, Huang, K, Marchesi, A, Heyam, A, Young, C, Charnock, S, Davies, G.J, Linclau, B, Flitsch, S.L, Fascione, M.A. 登録日 2019-11-12 公開日 2020-06-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides. Cell Chem Biol, 27, 2020

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