4EM9

Human PPAR gamma in complex with nonanoic acids

Summary for 4EM9

Related2VV1 1PRG 3GWX 1ZEO 3DZU 3DZY 4EMA
DescriptorPeroxisome proliferator-activated receptor gamma, nonanoic acid, GLYCEROL, ... (5 entities in total)
Functional Keywordsnuclear receptor, retinoic acid receptor, nucleus, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63980.4
Authors
Liberato, M.V.,Nascimento, A.S.,Polikarpov, I. (deposition date: 2012-04-11, release date: 2013-03-06)
Primary citation
Liberato, M.V.,Nascimento, A.S.,Ayers, S.D.,Lin, J.Z.,Cvoro, A.,Silveira, R.L.,Martinez, L.,Souza, P.C.,Saidemberg, D.,Deng, T.,Amato, A.A.,Togashi, M.,Hsueh, W.A.,Phillips, K.,Palma, M.S.,Neves, F.A.,Skaf, M.S.,Webb, P.,Polikarpov, I.
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists
Plos One, 7:e36297-e36297, 2012
PubMed: 22649490 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pone.0036297
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2291202.5%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report