4EMA

Human peroxisome proliferator-activated receptor gamma in complex with rosiglitazone

Summary for 4EMA

Related1ZEO 1PRG 3GWX 2VV1 3DZU 3DZY 4EM9
DescriptorPeroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) (3 entities in total)
Functional Keywordsnuclear receptor, retinoic acid receptor, nucleus, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63178.4
Authors
Liberato, M.V.,Nascimento, A.S.,Polikarpov, I. (deposition date: 2012-04-11, release date: 2013-03-06)
Primary citation
Liberato, M.V.,Nascimento, A.S.,Ayers, S.D.,Lin, J.Z.,Cvoro, A.,Silveira, R.L.,Martinez, L.,Souza, P.C.,Saidemberg, D.,Deng, T.,Amato, A.A.,Togashi, M.,Hsueh, W.A.,Phillips, K.,Palma, M.S.,Neves, F.A.,Skaf, M.S.,Webb, P.,Polikarpov, I.
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists
Plos One, 7:e36297-e36297, 2012
PubMed: 22649490 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pone.0036297
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.545 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.223230.6%14.8%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report