1ZEO

Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist

Summary for 1ZEO

DescriptorPeroxisome proliferator activated receptor gamma, (2S)-(4-ISOPROPYLPHENYL)[(2-METHYL-3-OXO-5,7-DIPROPYL-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)OXY]ACETATE (3 entities in total)
Functional Keywordsnuclear receptor, ligand binding domain, lbd, alpha helix sandwich, ppar-rxr heterodimer, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63611.81
Authors
Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.,Adams, A.D.,MacNaul, K.L.,Elbrecht, A.,Berger, J.P.,Zhou, G.,Doebber, T.W. (deposition date: 2005-04-19, release date: 2006-04-25, Last modification date: 2018-01-24)
Primary citation
Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.,Xu, S.,Becker, J.W.,Berger, J.P.,MacNaul, K.L.,Elbrecht, A.,Zhou, G.,Doebber, T.W.,Wang, P.,Chao, Y.-S.,Forrest, M.,Heck, J.V.,Moller, D.E.,Jones, B.A.
Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
J.Med.Chem., 48:4457-4468, 2005
PubMed: 15974597 (PDB entries with the same primary citation)
DOI: 10.1021/jm0502135
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.283151.6%8.4%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report