Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist

Summary for 1ZEO

DescriptorPeroxisome proliferator activated receptor gamma, (2S)-(4-ISOPROPYLPHENYL)[(2-METHYL-3-OXO-5,7-DIPROPYL-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)OXY]ACETATE (3 entities in total)
Functional Keywordsnuclear receptor, ligand binding domain, lbd, alpha helix sandwich, ppar-rxr heterodimer, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63611.81
Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.,Adams, A.D.,MacNaul, K.L.,Elbrecht, A.,Berger, J.P.,Zhou, G.,Doebber, T.W. (deposition date: 2005-04-19, release date: 2006-04-25, Last modification date: 2018-01-24)
Primary citation
Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.,Xu, S.,Becker, J.W.,Berger, J.P.,MacNaul, K.L.,Elbrecht, A.,Zhou, G.,Doebber, T.W.,Wang, P.,Chao, Y.-S.,Forrest, M.,Heck, J.V.,Moller, D.E.,Jones, B.A.
Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
J.Med.Chem., 48:4457-4468, 2005
PubMed: 15974597 (PDB entries with the same primary citation)
DOI: 10.1021/jm0502135
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.283151.6%8.4%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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