5O1Y
| Structure of Nrd1 RNA binding domain in complex with RNA (GUAA) | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Protein NRD1, ... | 著者 | Franco-Echevarria, E, Perez-Canadillas, J.M, Gonzalez, B. | 登録日 | 2017-05-19 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition. Nucleic Acids Res., 45, 2017
|
|
1U4B
| Extension of an adenine-8oxoguanine mismatch | 分子名称: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | 著者 | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | 登録日 | 2004-07-23 | 公開日 | 2004-09-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
|
|
4RZR
| Bypass of a bulky adduct dG1,8 by DPO4 | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | 著者 | Vyas, R, Suo, Z. | 登録日 | 2014-12-23 | 公開日 | 2015-09-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase. J.Am.Chem.Soc., 137, 2015
|
|
3LP3
| p15 HIV RNaseH domain with inhibitor MK3 | 分子名称: | 3-[4-(diethylamino)phenoxy]-6-(ethoxycarbonyl)-5,8-dihydroxy-7-oxo-7,8-dihydro-1,8-naphthyridin-1-ium, MANGANESE (II) ION, p15 | 著者 | Yan, Y, Munshi, S.K, Prasad, G.S, Su, H.P. | 登録日 | 2010-02-04 | 公開日 | 2010-06-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors. J.Virol., 84, 2010
|
|
4BWM
| KlenTaq mutant in complex with a RNA/DNA hybrid | 分子名称: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*DOCP)-3', 5'-R(*AP*AP*AP*GP*GP*GP*CP*GP*CP*CP*GP*UP*GP*GP*UP*C)-3', ... | 著者 | Blatter, N, Bergen, K, Welte, W, Diederichs, K, Marx, A. | 登録日 | 2013-07-03 | 公開日 | 2013-09-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | Structure and Function of an RNA-Reading Thermostable DNA Polymerase. Angew.Chem.Int.Ed.Engl., 52, 2013
|
|
4OL8
| Ty3 reverse transcriptase bound to DNA/RNA | 分子名称: | 5'-D(*CP*AP*TP*CP*TP*TP*CP*CP*TP*CP*TP*CP*TP*CP*TP*C)-3', 5'-R(*CP*UP*GP*AP*GP*AP*GP*AP*GP*AP*GP*GP*AP*AP*GP*AP*UP*G)-3', Reverse transcriptase/ribonuclease H, ... | 著者 | Nowak, E, Miller, J.T, Bona, M.K, Studnicka, J, Szczepanowski, R.H, Jurkowski, J, Le Grice, S.F.J, Nowotny, M. | 登録日 | 2014-01-23 | 公開日 | 2014-03-05 | 最終更新日 | 2014-04-16 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. Nat.Struct.Mol.Biol., 21, 2014
|
|
7DBN
| HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/M184V/F160M:DNA:dCTP ternary complex | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ... | 著者 | Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. | 登録日 | 2020-10-21 | 公開日 | 2021-08-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations. J.Virol., 95, 2021
|
|
7DBM
| HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/M184V:DNA:dGTP ternary complex | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ... | 著者 | Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. | 登録日 | 2020-10-21 | 公開日 | 2021-08-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations. J.Virol., 95, 2021
|
|
1U48
| Extension of a cytosine-8-oxoguanine base pair | 分子名称: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | 著者 | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | 登録日 | 2004-07-23 | 公開日 | 2004-09-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
|
|
5WU4
| |
5WU1
| |
6EPC
| Ground state 26S proteasome (GS2) | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | 著者 | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | 登録日 | 2017-10-11 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (12.3 Å) | 主引用文献 | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
|
|
6EPD
| Substrate processing state 26S proteasome (SPS1) | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | 著者 | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | 登録日 | 2017-10-11 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (15.4 Å) | 主引用文献 | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
|
|
6EPE
| Substrate processing state 26S proteasome (SPS2) | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | 著者 | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | 登録日 | 2017-10-11 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (12.8 Å) | 主引用文献 | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
|
|
6EPF
| Ground state 26S proteasome (GS1) | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | 著者 | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | 登録日 | 2017-10-11 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (11.8 Å) | 主引用文献 | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
|
|
5WU5
| |
6HY0
| Atomic models of P1, P4 C-terminal fragment and P8 fitted in the bacteriophage phi6 nucleocapsid reconstructed with icosahedral symmetry | 分子名称: | Major Outer Capsid Protein P8, Major inner protein P1, Packaging Enzyme P4 | 著者 | El Omari, K, Ilca, S.L, Stuart, D.I, Huiskonen, J.T. | 登録日 | 2018-10-18 | 公開日 | 2019-06-12 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus. Nature, 570, 2019
|
|
5WU2
| |
5WU3
| Crystal structure of human Tut1 bound with MgUTP, form II | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Yamashita, S, Tomita, K. | 登録日 | 2016-12-16 | 公開日 | 2017-05-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Crystal structures of U6 snRNA-specific terminal uridylyltransferase Nat Commun, 8, 2017
|
|
6VAG
| Crystal structure of the oligomerization domain of phosphoprotein from parainfluenza virus 5 | 分子名称: | GLYCEROL, Phosphoprotein | 著者 | Aggarwal, M, Abdella, R, He, Y, Lamb, R.A. | 登録日 | 2019-12-17 | 公開日 | 2020-02-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
3IG1
| HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site | 分子名称: | 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, HIV-1 Reverse Transcriptase p51 subunit, HIV-1 Reverse Transcriptase p66 subunit, ... | 著者 | Himmel, D.M, Maegley, K.A, Pauly, T.A, Arnold, E. | 登録日 | 2009-07-27 | 公開日 | 2010-01-26 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure, 17, 2009
|
|
6AF0
| Structure of Ctr9, Paf1 and Cdc73 ternary complex from Myceliophthora thermophila | 分子名称: | Cdc73 protein, Ctr9 protein, Paf1 protein | 著者 | Wang, Z, Deng, P, Zhou, Y. | 登録日 | 2018-08-07 | 公開日 | 2018-09-19 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
5W4F
| |
3QIP
| Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine | 分子名称: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 5,6-dihydroxy-2-[(2-phenyl-1H-indol-3-yl)methyl]pyrimidine-4-carboxylic acid, CHLORIDE ION, ... | 著者 | Lansdon, E.B, Kirschberg, T.A. | 登録日 | 2011-01-27 | 公開日 | 2011-04-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.0926 Å) | 主引用文献 | Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011
|
|
4UXB
| Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor PJ34 | 分子名称: | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, POLY ADP-RIBOSE POLYMERASE 1, SULFATE ION | 著者 | Tresaugues, L, Thorsell, A.G, Karlberg, T, Schuler, H. | 登録日 | 2014-08-21 | 公開日 | 2015-09-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60, 2017
|
|