PDB: 608 件ウェブページステータス検索Chemie searchBIRD

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4FJ3	14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide 分子名称: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase 著者 Ottmann, C, Molzan, M. 登録日 2012-06-11 公開日 2012-09-05 最終更新日 2013-07-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer J.Mol.Biol., 423, 2012
6Y3S	14-3-3 Sigma in complex with phosphorylated (pS210) Gab2 peptide 分子名称: 14-3-3 protein sigma, Gab2, MAGNESIUM ION 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-02-18 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes. Acta Crystallogr.,Sect.F, 76, 2020
5LVZ	Crystal structure of yeast 14-3-3 protein from Lachancea thermotolerans 分子名称: KLTH0G14146p 著者 Klima, M, Boura, E. 登録日 2016-09-14 公開日 2016-10-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation. Acta Crystallogr.,Sect.F, 72, 2016
6GHP	14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Potassium channel subfamily K member 9, ... 著者 Andrei, S.A, de Vink, P.J, Brunsveld, L, Ottmann, C, Higuchi, Y. 登録日 2018-05-08 公開日 2018-08-01 最終更新日 2018-10-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed. Engl., 57, 2018
8P1H	Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor 分子名称: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ... 著者 Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N. 登録日 2023-05-12 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. Biochem.Biophys.Res.Commun., 682, 2023
5EXA	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ... 著者 Bier, D, Ottmann, C. 登録日 2015-11-23 公開日 2016-05-04 最終更新日 2018-12-19 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
3P1P	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide 分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ... 著者 Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C. 登録日 2010-09-30 公開日 2011-10-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Chem. Biol., 20, 2013
7NNE	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 22 分子名称: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... 著者 Centorrino, F, Ottmann, C. 登録日 2021-02-24 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
8A9G	Binary complex of 14-3-3 zeta Glucocorticoid Receptor (GR) pT524 peptide stabilised by (R)-para chloropyrrolidone1 分子名称: 14-3-3 protein zeta/delta, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-[(2~{R})-3-(4-chlorophenyl)carbonyl-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid, ... 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2022-06-28 公開日 2022-12-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.961 Å) 主引用文献 Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
5WFU	Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate 分子名称: 14-3-3 protein beta/alpha, D-MALATE 著者 Hou, Z.Q, Liu, X.Y. 登録日 2017-07-12 公開日 2018-07-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate To Be Published
6BCR	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.986 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
3SPR	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer FC-THF 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin A-THF, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-07-03 公開日 2012-07-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
7OBD	Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide and stabilizer Fusicoccin-A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-21 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7BMC	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide and stabilizing Fusicoccin A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-01-19 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
7OBH	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-22 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
8BWE	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... 著者 Visser, E.J, Pennings, M.A.M, Ottmann, C. 登録日 2022-12-06 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
6KZG	14-3-3 protein in Complex with CIC S301 phosphorylated peptide 分子名称: 14-3-3 protein theta, ARG-SER-MET-SER-GLU-THR-GLY-THR 著者 Wen, Y, Shao, Y. 登録日 2019-09-24 公開日 2020-09-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 14-3-3 protein in Complex with CIC S301 phosphorylated peptide To Be Published
6S3C	Fragment AZ-019 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. 登録日 2019-06-25 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6FI4	Crystal structure of C-terminal modified Tau peptide-hybrid 3.2e with 14-3-3sigma 分子名称: (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2018-01-17 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
4DAU	Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif I 分子名称: 14-3-3 protein sigma, Peptidylarginine Deiminase type VI 著者 Rose, R, Rose, M, Ottmann, C. 登録日 2012-01-13 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J.Struct.Biol., 180, 2012
2C1N	Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 分子名称: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE 著者 Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C. 登録日 2005-09-16 公開日 2005-11-02 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3. Mol.Cell, 20, 2005
3O8I	Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment 分子名称: 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one 著者 Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P. 登録日 2010-08-03 公開日 2010-09-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling Mol.Cell.Biol., 30, 2010
6SLW	Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1 著者 Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. 登録日 2019-08-20 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
3SMN	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin A-THF 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-06-28 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
1QJB	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) 分子名称: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE 著者 Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. 登録日 1999-06-23 公開日 1999-09-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999

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