PDB: 229040 件ウェブページステータス検索Chemie searchBIRD

---

3HV4	Human p38 MAP Kinase in Complex with RL51 分子名称: 1-{3-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase 14, ... 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2009-06-15 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Displacement assay for the detection of stabilizers of inactive kinase conformations. J.Med.Chem., 53, 2010
2XCK	Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor 分子名称: 1-METHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-N-[(2-METHYLPYRIDIN-4-YL)METHYL]-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, ... 著者 Angiolini, M, Banfi, P, Casale, E, Casuscelli, F, Fiorelli, C, Saccardo, M.B, Silvagni, M, Zuccotto, F. 登録日 2010-04-23 公開日 2010-07-28 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Based Optimization of Potent Pdk1 Inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3QXR	Crystal structure of the brominated CKIT-1 proto-oncogene promoter quadruplex DNA 分子名称: 5'-D(*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*CP*(BRU)P*GP*GP*GP*AP*GP*GP*AP*GP*GP*G)-3', MAGNESIUM ION, POTASSIUM ION 著者 Wei, D, Parkinson, G.N, Neidle, S. 登録日 2011-03-02 公開日 2012-01-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res., 40, 2012
8I97	Structure of Apo-C3aR-Go complex (Glacios) 分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-06 公開日 2023-10-18 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
7W8K	Solution structures of a disulfide-rich peptide that can bind mdm2 分子名称: drp1 著者 Fan, S.H, Wu, Y.P, Wu, C.L. 登録日 2021-12-08 公開日 2022-06-08 最終更新日 2024-11-06 実験手法 SOLUTION NMR 主引用文献 Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery. Chem Sci, 13, 2022
2XMT	Copper chaperone Atx1 from Synechocystis PCC6803 (Cu1 form) 分子名称: COPPER (I) ION, SSR2857 PROTEIN 著者 Badarau, A, Firbank, S.J, McCarthy, A.A, Banfield, M.J, Dennison, C. 登録日 2010-07-29 公開日 2010-08-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Visualizing the Metal-Binding Versatility of Copper Trafficking Sites . Biochemistry, 49, 2010
7W8R	Solution structures of a disulfide-rich peptide that can bind mdm2 分子名称: drp2-b 著者 Fan, S.H, Wu, Y.P, Wu, C.L. 登録日 2021-12-08 公開日 2022-06-08 最終更新日 2024-10-23 実験手法 SOLUTION NMR 主引用文献 Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery. Chem Sci, 13, 2022
8E8C	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:reaction with 10 mM Mn2+ for 30s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
5DRP	Structure of the AaLpxC/LPC-023 Complex 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, N~2~-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-isoleucinamide, ... 著者 Najeeb, J, Lee, C.-J, Zhou, P. 登録日 2015-09-16 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.889 Å) 主引用文献 Drug design from the cryptic inhibitor envelope. Nat Commun, 7, 2016
8E8E	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:reaction with 10 mM Mn2+ for 90s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
2XFR	Crystal structure of barley beta-amylase at atomic resolution 分子名称: 1,2-ETHANEDIOL, BETA-AMYLASE 著者 Rejzek, M, Stevenson, C.E.M, Southard, A.M, Stanley, D, Denyer, K, Smith, A.M, Naldrett, M.J, Lawson, D.M, Field, R.A. 登録日 2010-05-28 公開日 2010-12-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (0.97 Å) 主引用文献 Chemical Genetics and Cereal Starch Metabolism: Structural Basis of the Non-Covalent and Covalent Inhibition of Barley Beta-Amylase. Mol.Biosyst., 7, 2011
8I9S	Structure of Apo-C3aR-Go complex (Titan) 分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-07 公開日 2023-10-18 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
5DSK	Structure of CO2 released holo-form of human carbonic anhydrase II with 3 min warming 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Kim, C.U, Park, S.Y, McKenna, R. 登録日 2015-09-17 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals Proc. Natl. Acad. Sci. U.S.A., 113, 2016
8IA2	Structure of C5a bound human C5aR1 in complex with Go (Composite map) 分子名称: Antibody fragment - ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-07 公開日 2023-10-18 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
5DSQ	Structure of CO2 released apo-form of human carbonic anhydrase II with 3 min warming 分子名称: Carbonic anhydrase 2, GLYCEROL 著者 Kim, C.U, Park, S.Y, McKenna, R. 登録日 2015-09-17 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals Proc. Natl. Acad. Sci. U.S.A., 113, 2016
9BG7	Tri-complex of Compound-6, KRAS G12V, and CypA 分子名称: Isoform 2B of GTPase KRas, MAGNESIUM ION, N-[(2R)-1-{[(1P,7S,9S,13R,20M)-21-ethyl-20-{2-[(1S)-1-methoxyethyl]pyridin-3-yl}-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]amino}-3-methyl-1-oxobutan-2-yl]-3-methoxy-N-methylazetidine-1-carboxamide (non-preferred name), ... 著者 Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. 登録日 2024-04-18 公開日 2025-03-19 最終更新日 2025-04-09 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. J.Med.Chem., 68, 2025
2J9I	Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re- engineering for a tissue-specific role in the vertebrate eye lens. 分子名称: GLUTAMATE-AMMONIA LIGASE DOMAIN-CONTAINING PROTEIN 1 著者 Wyatt, K, White, H.E, Wang, L, Bateman, O.A, Slingsby, C, Orlova, E.V, Wistow, G. 登録日 2006-11-09 公開日 2006-12-13 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (17 Å) 主引用文献 Lengsin is a Survivor of an Ancient Family of Class I Glutamine Synthetases Re-Engineered by Evolution for a Role in the Vertebrate Lens. Structure, 14, 2006
9G0P	Xenopus laevis undecorated microtubule - 14 protofilament, 3-start helix 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Troman, L.A, Moores, C.A. 登録日 2024-07-08 公開日 2025-01-15 最終更新日 2025-02-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Mechanistic basis of temperature adaptation in microtubule dynamics across frog species. Curr.Biol., 35, 2025
8E89	Human DNA polymerase eta-DNA-rU-ended primer-binary complex 分子名称: DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*U)-3') 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
8E8H	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:reaction with 10 mM Mn2+ for 300s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
1BFV	MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI 分子名称: ESTRIOL 3-(B-D-GLUCURONIDE), FV4155, ZINC ION 著者 Trinh, C.H, Phillips, S.E.V. 登録日 1997-05-27 公開日 1997-12-03 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Antibody fragment Fv4155 bound to two closely related steroid hormones: the structural basis of fine specificity. Structure, 5, 1997
6I82	Crystal structure of partially phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018412 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, FORMIC ACID, ... 著者 Burschowsky, D, Seewooruthun, C, Bayliss, R, Carr, M.D, Echalier, A, Jordan, A.M. 登録日 2018-11-19 公開日 2020-03-11 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804MKinase. Acs Med.Chem.Lett., 11, 2020
8E8D	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:reaction with 10 mM Mn2+ for 60s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
1DRF	CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE 分子名称: DIHYDROFOLATE REDUCTASE, FOLIC ACID, SULFATE ION 著者 Oefner, C, D'Arcy, A, Winkler, F.K. 登録日 1990-08-09 公開日 1992-01-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of human dihydrofolate reductase complexed with folate. Eur.J.Biochem., 174, 1988
9G0O	Xenopus borealis undecorated microtubule - 14 protofilament, 3-start helix 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Troman, L.A, Moores, C.A. 登録日 2024-07-08 公開日 2025-01-15 最終更新日 2025-02-12 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Mechanistic basis of temperature adaptation in microtubule dynamics across frog species. Curr.Biol., 35, 2025

<1679168016811682168316841685168616871688168916901691169216931694>