5DRP

Structure of the AaLpxC/LPC-023 Complex

Summary for 5DRP

Entry DOI	10.2210/pdb5drp/pdb
Related	5DRO 5DRQ 5DRR
Descriptor	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N~2~-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-isoleucinamide, ... (6 entities in total)
Functional Keywords	lpxc, inhibitor, lipid a, gram-negative bacteria, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Aquifex aeolicus (strain VF5)
Total number of polymer chains	2
Total formula weight	63653.03
Authors	Najeeb, J.,Lee, C.-J.,Zhou, P. (deposition date: 2015-09-16, release date: 2016-03-09, Last modification date: 2023-09-27)
Primary citation	Lee, C.J.,Liang, X.,Wu, Q.,Najeeb, J.,Zhao, J.,Gopalaswamy, R.,Titecat, M.,Sebbane, F.,Lemaitre, N.,Toone, E.J.,Zhou, P. Drug design from the cryptic inhibitor envelope. Nat Commun, 7:10638-10638, 2016 Cited by PubMed: 26912110 DOI: 10.1038/ncomms10638 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.889 Å)

Structure validation