3QXR

Crystal structure of the brominated CKIT-1 proto-oncogene promoter quadruplex DNA

Summary for 3QXR

• Entry DOI: 10.2210/pdb3qxr/pdb
• Descriptor: 5'-D(*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*CP*(BRU)P*GP*GP*GP*AP*GP*GP*AP*GP*GP*G)-3', POTASSIUM ION, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: dna quadruplex, regulation, ckit-1, dna
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 14587.26

Authors

Wei, D.,Parkinson, G.N.,Neidle, S. (deposition date: 2011-03-02, release date: 2012-01-18, Last modification date: 2023-09-13)

• Primary citation: Wei, D.,Parkinson, G.N.,Reszka, A.P.,Neidle, S.; Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation.; Nucleic Acids Res., 40:4691-4700, 2012; PubMed: 22287624; DOI: 10.1093/nar/gks023

Experimental method

X-RAY DIFFRACTION (1.62 Å)