6ZX0
| OMPD-domain of human UMPS in complex with the substrate OMP at 1.25 Angstroms resolution | 分子名称: | GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... | 著者 | Tittmann, K, Rindfleisch, S, Krull, M. | 登録日 | 2020-07-29 | 公開日 | 2022-02-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
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6ZX2
| OMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolution | 分子名称: | PROLINE, SULFATE ION, Uridine 5'-monophosphate synthase, ... | 著者 | Tittmann, K, Rindfleisch, S, Schimdt, T. | 登録日 | 2020-07-29 | 公開日 | 2022-02-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
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5H8Q
| Structure of the human GluN1/GluN2A LBD in complex with GNE8324 | 分子名称: | 6-[[ethyl-(4-fluorophenyl)amino]methyl]-2,3-dihydro-1~{H}-cyclopenta[3,4][1,3]thiazolo[1,4-~{a}]pyrimidin-8-one, ACETATE ION, GLUTAMIC ACID, ... | 著者 | Wallweber, H.J.A, Lupardus, P.J. | 登録日 | 2015-12-23 | 公開日 | 2016-02-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
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5H8H
| Structure of the human GluN1/GluN2A LBD in complex with GNE3419 | 分子名称: | 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ACETATE ION, CALCIUM ION, ... | 著者 | Wallweber, H.J.A, Lupardus, P.J. | 登録日 | 2015-12-23 | 公開日 | 2016-02-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
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5H8N
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7JJD
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9AUE
| Crystal structure of the holo form of GenB2 in complex with PMP | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 6'-epimerase, C-6' aminotransferase, ... | 著者 | Oliveira, G.S, Bury, P.S, Huang, F, Li, Y, Araujo, N.C, Zhou, J, Sun, Y, Leeper, F, Leadlay, P, Dias, M.V.B. | 登録日 | 2024-02-29 | 公開日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis. Acs Chem.Biol., 2024
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9B0C
| Crystal structure of GenB2 in complex with gentamicin X2. | 分子名称: | (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 6'-epimerase, ... | 著者 | Bury, P.S, Araujo, N.C, Oliveira, G.S, Dias, M.V.B. | 登録日 | 2024-03-11 | 公開日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis. Acs Chem.Biol., 2024
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9AU3
| Crystal structure of GenB2 in complex with G418 | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 6'-epimerase, C-6' aminotransferase, ... | 著者 | De Oliveira, G.S, Bury, P.S, Huang, F, Li, Y, Araujo, N.C, Zhou, J, Sun, Y, Leeper, F, Leadlay, P, Dias, M.V.B. | 登録日 | 2024-02-28 | 公開日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis. Acs Chem.Biol., 2024
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4PE5
| Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... | 著者 | Karakas, E, Furukawa, H. | 登録日 | 2014-04-22 | 公開日 | 2014-06-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.96 Å) | 主引用文献 | Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344, 2014
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6Z1F
| CryoEM structure of Rubisco Activase with its substrate Rubisco from Nostoc sp. (strain PCC7120) | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Wang, H, Bracher, A, Flecken, M, Popilka, L, Hartl, F.U, Hayer-Hartl, M. | 登録日 | 2020-05-13 | 公開日 | 2020-09-23 | 最終更新日 | 2021-04-07 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes. Cell, 183, 2020
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2A4T
| Crystal structure of spin labeled T4 Lysozyme (V131R7) | 分子名称: | 2-HYDROXYETHYL DISULFIDE, AZIDE ION, CHLORIDE ION, ... | 著者 | Fleissner, M.R, Cascio, D, Sawaya, M.R, Hideg, K, Hubbell, W.L. | 登録日 | 2005-06-29 | 公開日 | 2006-06-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of spin labeled T4 Lysozyme (V131R7 To be Published
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8W7M
| Yeast replisome in state V | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (71-mer), ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | 登録日 | 2023-08-30 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.12 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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1S08
| Crystal Structure of the D147N Mutant of 7,8-Diaminopelargonic Acid Synthase | 分子名称: | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, SODIUM ION | 著者 | Sandmark, J, Eliot, A.C, Famm, K, Schneider, G, Kirsch, J.F. | 登録日 | 2003-12-30 | 公開日 | 2004-03-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Conserved and nonconserved residues in the substrate binding site of 7,8-diaminopelargonic acid synthase from Escherichia coli are essential for catalysis. Biochemistry, 43, 2004
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5Z8A
| Crystal structure of GenB1 from Micromonospora echinospora in complex with JI-20A and PLP (external aldimine) | 分子名称: | (2~{R},3~{R},4~{R},5~{R})-2-[(1~{S},2~{S},3~{R},4~{S},6~{R})-3-[(2~{R},3~{R},4~{R},5~{S},6~{R})-6-(aminomethyl)-3-azany l-4,5-bis(oxidanyl)oxan-2-yl]oxy-4,6-bis(azanyl)-2-oxidanyl-cyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol, C-6' aminotransferase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Hong, S.K, Cha, S.S. | 登録日 | 2018-01-31 | 公開日 | 2019-01-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.398 Å) | 主引用文献 | Complete reconstitution of the diverse pathways of gentamicin B biosynthesis. Nat. Chem. Biol., 15, 2019
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5Z83
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5L2E
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5KUF
| GluK2EM with 2S,4R-4-methylglutamate | 分子名称: | 2S,4R-4-METHYLGLUTAMATE, Glutamate receptor ionotropic, kainate 2 | 著者 | Meyerson, J.R, Chittori, S, Merk, A, Rao, P, Han, T.H, Serpe, M, Mayer, M.L, Subramaniam, S. | 登録日 | 2016-07-13 | 公開日 | 2016-09-07 | 最終更新日 | 2019-11-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis of kainate subtype glutamate receptor desensitization. Nature, 537, 2016
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7SCW
| KRAS full length wild-type in complex with RGL1 Ras association domain | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | 著者 | Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. | 登録日 | 2021-09-29 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant. J.Mol.Biol., 434, 2022
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7SCX
| KRAS full-length G12V in complex with RGL1 Ras association domain | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | 著者 | Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. | 登録日 | 2021-09-29 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant. J.Mol.Biol., 434, 2022
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9BIB
| Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation, C1 symmetry | 分子名称: | GLUTAMIC ACID, GLYCINE, Glutamate receptor, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2024-04-23 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | Molecular mechanism of ligand gating and opening of NMDA receptor. Nature, 632, 2024
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6CWS
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7UVF
| Crystal structure of ZED8 Fab complex with CD8 alpha | 分子名称: | CHLORIDE ION, GLYCEROL, Immunoglobulin heavy chain, ... | 著者 | Yu, C, Davies, C, Koerber, J.T, Williams, S. | 登録日 | 2022-05-01 | 公開日 | 2022-10-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Preclinical development of ZED8, an 89 Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy. Eur J Nucl Med Mol Imaging, 50, 2023
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6FE6
| Solution structure of a last generation P2-P4 macrocyclic inhibitor | 分子名称: | (3aR,7S,10S,12R,24aR)-7-cyclopentyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-5,8-dioxo-1,2,3,3a,5,6,7,8,11,12,20,21,22,23,24,24a-hexadecahydro-10H-9,12-methanocyclopenta[18,19][1,10,3,6]dioxadiazacyclononadecino[12,11-b]quinoline-10-carboxamide, Non-structural 3 protease, ZINC ION | 著者 | Gallo, M, Eliseo, T, Cicero, D.O. | 登録日 | 2017-12-29 | 公開日 | 2019-01-30 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a last generation macrocyclic inhibitor. Hepatitis C virus NS3 protease complex: when S prime region occupancy is not enough to stabilize the protein conformation in the absence of NS4A. To Be Published
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5YKR
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