PDB: 243911 件ウェブページステータス検索Chemie searchBIRD

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1ZSH	Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6) 分子名称: Beta-arrestin 1, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION 著者 Milano, S.K, Kim, Y.M, Stefano, F.P, Benovic, J.L, Brenner, C. 登録日 2005-05-24 公開日 2006-01-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding J.Biol.Chem., 281, 2006
2P55	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP 分子名称: 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Ohren, J.F, Pavlovsky, A.G. 登録日 2007-03-14 公開日 2007-10-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J.Med.Chem., 50, 2007
7SKM	Complex between S. aureus aureolysin and wt IMPI. 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Mendes, S.R, Eckhard, U, Rodriguez-Banqueri, A, Guevara, T, Gomis-Ruth, F.X. 登録日 2021-10-21 公開日 2022-01-26 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin Comput Struct Biotechnol J, 20, 2022
6D5J	Ras:SOS:Ras in complex with a small molecule activator 分子名称: 6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazole, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Hodges, T, Fesik, S.W. 登録日 2018-04-19 公開日 2018-09-19 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.751 Å) 主引用文献 Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J. Med. Chem., 61, 2018
3EQD	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P 分子名称: CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Fischmann, T.O. 登録日 2008-09-30 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
4NMS	CFTR Associated Ligand (CAL)PDZ domain bound to peptide iCAL36(FLB-K-1) (ANSRWPTS[4-fluorobenzoic-acyl-K]I) 分子名称: GLYCEROL, Golgi-associated PDZ and coiled-coil motif-containing protein, iCAL36(FLB-K-1) peptide 著者 Amacher, J.F, Madden, D.R. 登録日 2013-11-15 公開日 2014-10-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Chemically Modified Peptide Scaffolds Target the CFTR-Associated Ligand PDZ Domain. Plos One, 9, 2014
3EHT	Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF 分子名称: Corticoliberin, FUSION PROTEIN OF CRFR1 EXTRACELLULAR DOMAIN AND MBP, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Pioszak, A.A, Xu, H.E. 登録日 2008-09-14 公開日 2008-09-30 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1. J.Biol.Chem., 283, 2008
1ZW5	X-ray structure of Farnesyl diphosphate synthase protein 分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, MAGNESIUM ION, ZOLEDRONIC ACID, ... 著者 Kavanagh, K.L, Guo, K, Wu, X, von Delft, F, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2005-06-03 公開日 2005-06-28 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc.Natl.Acad.Sci.USA, 103, 2006
2P97	CRYSTAL STRUCTURE OF A PUTATIVE METAL-DEPENDENT HYDROLASE (AVA_3068) FROM ANABAENA VARIABILIS ATCC 29413 AT 1.65 A RESOLUTION 分子名称: CHLORIDE ION, Hypothetical protein, MAGNESIUM ION 著者 Joint Center for Structural Genomics (JCSG) 登録日 2007-03-23 公開日 2007-04-17 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of hypothetical protein (YP_323572.1) from Anabaena variabilis ATCC 29413 at 1.65 A resolution To be published
7SKL	Complex between S. aureus aureolysin and IMPI mutant I57I 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, IMPI alpha, ... 著者 Mendes, S.R, Eckhard, U, Rodriguez-Banqueri, A, Guevara, T, Gomis-Ruth, F.X. 登録日 2021-10-21 公開日 2022-01-26 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin Comput Struct Biotechnol J, 20, 2022
1ZZ2	Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes 分子名称: Mitogen-activated protein kinase 14, N-[3-(4-FLUOROPHENOXY)PHENYL]-4-[(2-HYDROXYBENZYL)AMINO]PIPERIDINE-1-SULFONAMIDE, octyl beta-D-glucopyranoside 著者 Michelotti, E.L, Moffett, K.K, Springman, E.B, Karpusas, M. 登録日 2005-06-13 公開日 2005-10-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg.Med.Chem.Lett., 15, 2005
4NEQ	The structure of UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, UDP-N-acetylglucosamine 2-epimerase 著者 Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. 登録日 2013-10-29 公開日 2014-04-23 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAc. Proteins, 82, 2014
8JD5	Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer 分子名称: 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine, ... 著者 Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Zhao, Q, Wu, B. 登録日 2023-05-12 公開日 2023-06-21 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
1ZX8	CRYSTAL STRUCTURE OF an atypical cyclophilin (peptidylprolyl cis-trans isomerase) (TM1367) FROM THERMOTOGA MARITIMA AT 1.90 A RESOLUTION 分子名称: NICKEL (II) ION, PENTAETHYLENE GLYCOL, hypothetical protein TM1367 著者 Joint Center for Structural Genomics (JCSG) 登録日 2005-06-07 公開日 2005-07-26 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins, 63, 2006
8PKC	Structure of Api m1 in complex with the AM1-4 nanobody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM1-4 nanobody, Phospholipase A2 著者 Aagaard, J.B, Gandini, R, Spillner, E, Miehe, M. 登録日 2023-06-26 公開日 2024-05-08 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Nanobody-based IgG formats as blocking antibodies of the major honeybee venom allergen Api m 1 To be published
3ECG	High Resolution HIV-2 Protease Structure in Complex with Antiviral Inhibitor GRL-98065 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(2S,3R)-3-HYDROXY-4-(N-ISOBUTYLBENZO[D][1,3]DIOXOLE-5-SULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, CHLORIDE ION, IMIDAZOLE, ... 著者 Kovalevsky, A.Y, Weber, I.T. 登録日 2008-08-29 公開日 2008-09-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease J.Mol.Biol., 384, 2008
3EDD	Structural base for cyclodextrin hydrolysis 分子名称: CALCIUM ION, Cyclohexakis-(1-4)-(alpha-D-glucopyranose), Cyclomaltodextrinase 著者 Buedenbender, S, Schulz, G.E. 登録日 2008-09-03 公開日 2009-03-03 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural base for enzymatic cyclodextrin hydrolysis J.Mol.Biol., 385, 2009
3VSU	The complex structure of XylC with xylobiose 分子名称: Xylosidase, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose 著者 Huang, C.H, Sun, Y, Ko, T.P, Ma, Y, Chen, C.C, Zheng, Y, Chan, H.C, Pang, X, Wiegel, J, Shao, W, Guo, R.T. 登録日 2012-05-09 公開日 2013-02-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The substrate/product-binding modes of a novel GH120 beta-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485 Biochem.J., 448, 2012
2P1Q	Mechanism of Auxin Perception by the TIR1 ubiquitin ligase 分子名称: 1H-INDOL-3-YLACETIC ACID, Auxin-responsive protein IAA7, INOSITOL HEXAKISPHOSPHATE, ... 著者 Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, N. 登録日 2007-03-06 公開日 2007-04-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature, 446, 2007
7S5R	Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibodies CV07-287 and COVA1-16 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, COVA1-16 Heavy chain, ... 著者 Yuan, M, Wilson, I.A. 登録日 2021-09-11 公開日 2022-03-09 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies. Science, 375, 2022
4NO5	Crystal structure of non-phosphorylated form of AMPD2 phosphopeptide bound to HLA-A2 分子名称: 1,2-ETHANEDIOL, AMP deaminase 2, Beta-2-microglobulin, ... 著者 Mohammed, F, Stones, D.H, Willcox, B.E. 登録日 2013-11-19 公開日 2014-12-24 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status. Oncotarget, 8, 2017
5G0M	beta-glucuronidase with an activity-based probe (N-acyl cyclophellitol aziridine) bound 分子名称: (1S,2R,3R,4S,6S)-6-[(8-azidooctanoyl)amino]-2,3,4-trihydroxycyclohexane-1-carboxylate, BETA-GLUCURONIDASE, PHOSPHATE ION 著者 Jin, Y, Wu, L, Jiang, J.B, Overkleeft, H.S, Davies, G.J. 登録日 2016-03-21 公開日 2017-04-12 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Structure of a Bacteria Beta-Glucuronidase in Gh79 Family To be Published
1ZV9	Crystal structure analysis of a type II cohesin domain from the cellulosome of Acetivibrio cellulolyticus- SeMet derivative 分子名称: 1,2-ETHANEDIOL, 1,3-PROPANDIOL, ACETIC ACID, ... 著者 Noach, I, Rosenheck, S, Lamed, R, Shimon, L, Bayer, E, Frolow, F. 登録日 2005-06-01 公開日 2006-06-13 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Intermodular linker flexibility revealed from crystal structures of adjacent cellulosomal cohesins of Acetivibrio cellulolyticus. J.Mol.Biol., 391, 2009
8UTX	Solution structure of a 12-mer peptide bearing a bicyclic Asx motif mimic (BAMM) as a synthetic N-cap 分子名称: 1,3,5-tris(bromomethyl)benzene, TRP-CYS-ASP-ALA-ALA-CYS-CYS-ALA-ALA-ALA-LYS-ALA-NH2 peptide 著者 Mi, T.X, Burgess, K. 登録日 2023-10-31 公開日 2024-06-05 最終更新日 2024-10-23 実験手法 SOLUTION NMR 主引用文献 Bioinformatics leading to conveniently accessible, helix enforcing, bicyclic ASX motif mimics (BAMMs). Nat Commun, 15, 2024
5EVK	Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor L-CS319 分子名称: (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ... 著者 Hinchliffe, P, Spencer, J. 登録日 2015-11-19 公開日 2016-06-01 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.627 Å) 主引用文献 Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Proc.Natl.Acad.Sci.USA, 113, 2016

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