3ECG

High Resolution HIV-2 Protease Structure in Complex with Antiviral Inhibitor GRL-98065

Summary for 3ECG

Entry DOI	10.2210/pdb3ecg/pdb
Related	3EBZ 3EC0
Descriptor	Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(2S,3R)-3-HYDROXY-4-(N-ISOBUTYLBENZO[D][1,3]DIOXOLE-5-SULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, IMIDAZOLE, ... (7 entities in total)
Functional Keywords	hiv-2, aspartic protease, inhibitor, protease-inhibitor complex, hydrolase
Biological source	Human immunodeficiency virus type 2 (ISOLATE ROD)
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584
Total number of polymer chains	2
Total formula weight	23509.41
Authors	Kovalevsky, A.Y.,Weber, I.T. (deposition date: 2008-08-29, release date: 2008-09-16, Last modification date: 2023-11-01)
Primary citation	Kovalevsky, A.Y.,Louis, J.M.,Aniana, A.,Ghosh, A.K.,Weber, I.T. Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease J.Mol.Biol., 384:178-192, 2008 Cited by PubMed: 18834890 DOI: 10.1016/j.jmb.2008.09.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.18 Å)

Structure validation