Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 065 A 201 |
| Chain | Residue |
| A | ASP25 |
| A | ILE84 |
| A | HOH1017 |
| A | HOH1083 |
| B | ASP125 |
| B | GLY127 |
| B | ALA128 |
| B | ASP129 |
| B | ASP130 |
| B | ILE132 |
| B | GLY148 |
| A | GLY27 |
| B | GLY149 |
| B | ILE150 |
| A | ALA28 |
| A | ASP30 |
| A | ILE32 |
| A | GLY48 |
| A | GLY49 |
| A | PRO81 |
| A | ILE82 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IMD A 304 |
| Chain | Residue |
| A | GLN2 |
| A | PHE3 |
| A | LEU99 |
| A | ZN404 |
| A | CL509 |
| B | PRO101 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE IMD A 306 |
| Chain | Residue |
| A | TYR14 |
| A | GLU16 |
| A | GLY17 |
| A | GLU63 |
| A | GLU65 |
| A | GLU65 |
| A | ZN407 |
| A | ZN411 |
| A | HOH1011 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 402 |
| Chain | Residue |
| A | ASP30 |
| A | CL503 |
| A | HOH1026 |
| A | HOH1027 |
| A | HOH1028 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 404 |
| Chain | Residue |
| A | LEU99 |
| A | IMD304 |
| A | CL509 |
| A | HOH1007 |
| A | HOH1008 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 406 |
| Chain | Residue |
| A | ASP79 |
| A | HOH1032 |
| A | HOH1033 |
| B | GLU137 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 407 |
| Chain | Residue |
| A | GLU65 |
| A | GLU65 |
| A | IMD306 |
| A | HOH1005 |
| A | HOH1005 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 411 |
| Chain | Residue |
| A | GLU63 |
| A | GLU65 |
| A | IMD306 |
| A | CL507 |
| A | HOH1009 |
| A | HOH1011 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 503 |
| Chain | Residue |
| A | ASP30 |
| A | ZN402 |
| A | HOH1026 |
| B | LYS157 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 507 |
| Chain | Residue |
| A | GLU63 |
| A | GLU65 |
| A | ASN68 |
| A | LYS69 |
| A | ZN411 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 509 |
| Chain | Residue |
| A | LEU99 |
| A | IMD304 |
| A | ZN404 |
| A | HOH1008 |
| A | HOH1101 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 601 |
| Chain | Residue |
| A | ASN40 |
| A | ASN41 |
| A | PRO44 |
| A | HOH1067 |
| A | HOH1088 |
| A | HOH1104 |
| B | ASN140 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IMD B 301 |
| Chain | Residue |
| B | GLU121 |
| B | ILE146 |
| B | ASN155 |
| B | ASP179 |
| B | IMD302 |
| B | ZN401 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IMD B 302 |
| Chain | Residue |
| B | GLU121 |
| B | PHE153 |
| B | ASP179 |
| B | IMD301 |
| B | ZN401 |
| B | HOH1169 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IMD B 303 |
| Chain | Residue |
| B | CL502 |
| B | ASP130 |
| B | ILE146 |
| B | ZN403 |
| B | ZN410 |
| B | CL501 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IMD B 305 |
| Chain | Residue |
| A | PRO81 |
| B | TRP106 |
| B | ZN405 |
| B | CL505 |
| B | CL506 |
| B | CL508 |
| B | HOH1062 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 401 |
| Chain | Residue |
| B | GLU121 |
| B | ASP179 |
| B | IMD301 |
| B | IMD302 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 403 |
| Chain | Residue |
| B | ASP130 |
| B | IMD303 |
| B | ZN410 |
| B | CL502 |
| B | HOH1001 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 405 |
| Chain | Residue |
| B | IMD305 |
| B | CL505 |
| B | CL506 |
| B | CL508 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 408 |
| Chain | Residue |
| B | GLU165 |
| B | CL504 |
| B | HOH1002 |
| B | HOH1003 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 409 |
| Chain | Residue |
| B | GLU158 |
| B | HOH1010 |
| B | HOH1113 |
| B | HOH1144 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 410 |
| Chain | Residue |
| B | ASP130 |
| B | IMD303 |
| B | ZN403 |
| B | HOH1001 |
| B | HOH1004 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 501 |
| Chain | Residue |
| B | THR112 |
| B | LYS145 |
| B | ILE146 |
| B | IMD303 |
| B | HOH1053 |
| B | HOH1092 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 502 |
| Chain | Residue |
| B | LYS107 |
| B | GLY148 |
| B | IMD303 |
| B | ZN403 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 504 |
| Chain | Residue |
| B | ZN408 |
| B | HOH1003 |
| site_id | CC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CL B 505 |
| Chain | Residue |
| B | SER104 |
| B | LEU105 |
| B | TRP106 |
| B | LYS107 |
| B | IMD305 |
| B | ZN405 |
| B | CL506 |
| B | CL508 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 506 |
| Chain | Residue |
| B | IMD305 |
| B | ZN405 |
| B | CL505 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 508 |
| Chain | Residue |
| A | ARG8 |
| B | IMD305 |
| B | ZN405 |
| B | CL505 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VLLDTGADDSIV |
| Chain | Residue | Details |
| A | VAL22-VAL33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| B | THR126 | |
| B | ASP125 | |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| B | ASP125 | |
