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5CJ7
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Human DNA polymerase lambda L431A mutant- MgdTTP binary and complex with 6 paired DNA
分子名称: DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), DNA polymerase lambda, ...
著者Liu, M.S, Tsai, M.D.
登録日2015-07-14
公開日2016-02-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
1ONB
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Solution structure of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase
分子名称: helicase NS3
著者Liu, D, Wang, Y.S, Gesell, J.J, Wyss, D.F.
登録日2003-02-27
公開日2003-03-11
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase
J.Mol.Biol., 314, 2001
3PZP
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Human DNA polymerase kappa extending opposite a cis-syn thymine dimer
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*CP*A)-3', 5'-D(*TP*TP*CP*CP*(TTD)P*GP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ...
著者Vasquez-Del Carpio, R, Silverstein, T.D, Lone, S, Johnson, R.E, Prakash, S, Prakash, L, Aggarwal, A.K.
登録日2010-12-14
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.336 Å)
主引用文献Role of human DNA polymerase kappa in extension opposite from a cis-syn thymine dimer.
J.Mol.Biol., 408, 2011
2RDJ
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Snapshots of a Y-family DNA polymerase in replication: Dpo4 in apo and binary/ternary complex forms
分子名称: CALCIUM ION, DNA (5'-D(*DGP*DGP*DGP*DAP*DCP*DCP*DCP*DTP*DTP*DCP*DGP*DAP*DAP*DT)-3'), DNA (5'-D(P*DTP*DAP*DTP*DTP*DCP*DGP*DAP*DAP*DGP*DGP*DGP*DTP*DCP*DCP*DC)-3'), ...
著者Wong, J.H.Y, Ling, H.
登録日2007-09-24
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4.
J.Mol.Biol., 379, 2008
1TXS
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STEM-LOOP D OF THE CLOVERLEAF DOMAIN OF ENTEROVIRAL 5'UTR RNA
分子名称: Enteroviral 5'-UTR
著者Du, Z, Yu, J, Ulyanov, N.B, Andino, R, James, T.L.
登録日2004-07-06
公開日2004-10-05
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution Structure of a Consensus Stem-Loop D RNA Domain that Plays Important Roles in Regulating Translation and Replication in Enteroviruses and Rhinoviruses
Biochemistry, 43, 2004
3RH4
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DNA Polymerase Beta with a dideoxy-terminated primer with an incoming ribonucleotide (rCTP)
分子名称: 5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DDG))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
著者Cavanaugh, N.A, Beard, W.A, Batra, V.K, Perera, L, Pedersen, L.G, Wilson, S.H.
登録日2011-04-11
公開日2011-07-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.918 Å)
主引用文献Molecular insights into DNA polymerase deterrents for ribonucleotide insertion.
J.Biol.Chem., 286, 2011
2RDI
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Snapshots of a Y-family DNA polymerase in replication: Dpo4 in apo and binary/ternary complex forms
分子名称: DI(HYDROXYETHYL)ETHER, DNA polymerase IV, GLYCEROL
著者Wong, J.H.Y, Ling, H.
登録日2007-09-24
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4.
J.Mol.Biol., 379, 2008
3RH5
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DNA Polymerase Beta Mutant (Y271) with a dideoxy-terminated primer with an incoming deoxynucleotide (dCTP)
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DDG))-3', ...
著者Cavanaugh, N.A, Beard, W.A, Batra, V.K, Perera, L, Pedersen, L.G, Wilson, S.H.
登録日2011-04-11
公開日2011-07-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.096 Å)
主引用文献Molecular insights into DNA polymerase deterrents for ribonucleotide insertion.
J.Biol.Chem., 286, 2011
3RH6
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DNA Polymerase Beta Mutant (Y271) with a dideoxy-terminated primer with an incoming ribonucleotide (rCTP)
分子名称: (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DDG))-3'), (5'-D(P*GP*TP*CP*GP*G)-3'), 5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', ...
著者Cavanaugh, N.A, Beard, W.A, Batra, V.K, Perera, L, Pedersen, L.G, Wilson, S.H.
登録日2011-04-11
公開日2011-07-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.048 Å)
主引用文献Molecular insights into DNA polymerase deterrents for ribonucleotide insertion.
J.Biol.Chem., 286, 2011
4ECR
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Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 40 sec
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-26
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.892 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
1AJF
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SOLUTION STRUCTURE OF THE P5B STEM LOOP FROM A GROUP I INTRON COMPLEXED WITH COBALT (III) HEXAMMINE, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称: COBALT HEXAMMINE(III), RNA (5'-R(*GP*AP*CP*AP*GP*GP*GP*GP*AP*AP*AP*CP*UP*UP*UP*GP*UP*C)-3')
著者Kieft, J.S, Tinoco Junior, I.
登録日1997-05-02
公開日1997-07-07
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of a metal-binding site in the major groove of RNA complexed with cobalt (III) hexammine.
Structure, 5, 1997
3FDS
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Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA polymerase IV, ...
著者Ling, H.
登録日2008-11-26
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA
Mol.Microbiol., 71, 2009
3GEY
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Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment in complex with an inhibitor Pj34
分子名称: N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, Poly [ADP-ribose] polymerase 15
著者Karlberg, T, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
登録日2009-02-26
公開日2009-03-24
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein.
J.Biol.Chem., 290, 2015
2A0C
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Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
分子名称: 2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL, Cell division protein kinase 2
著者Krystof, V, McNae, I.W, Walkinshaw, M.D, Fischer, P.M, Muller, P, Vojtesek, B, Orsag, M, Havlicek, L, Strnad, M.
登録日2005-06-16
公開日2006-01-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Cell.Mol.Life Sci., 62, 2005
2PZS
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Phi29 DNA polymerase complexed with primer-template DNA (post-translocation binary complex)
分子名称: 5'-d(CTAACACGTAAGCAGTC)-3', 5'-d(GACTGCTTAC)-3', DNA polymerase
著者Berman, A.J, Kamtekar, S, Goodman, J.L, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A.
登録日2007-05-18
公開日2007-07-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases
Embo J., 26, 2007
2PY5
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Phi29 DNA polymerase complexed with single-stranded DNA
分子名称: 1,2-ETHANEDIOL, 5'-d(GGACTTT)-3', DNA polymerase
著者Berman, A.J, Kamtekar, S, Goodman, J.L, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A.
登録日2007-05-15
公開日2007-07-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases
Embo J., 26, 2007
4P4M
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Crystal structure of Leishmania infantum polymerase beta: Ternary P/T complex
分子名称: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*TP*A)-3'), DNA (5'-D(P*AP*TP*AP*CP*TP*G)-3'), ...
著者Mejia, E, Burak, M, Alonso, A, Larraga, V, Kunkel, T.A, Bebenek, K, Garcia-Diaz, M.
登録日2014-03-12
公開日2014-08-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9185 Å)
主引用文献Structures of the Leishmania infantum polymerase beta.
DNA Repair (Amst.), 18, 2014
2Z7J
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Structural insights into de multifunctional VP3 protein of birnaviruses:gold derivative
分子名称: Capsid assembly protein VP3, GOLD ION
著者Casanas, A, Navarro, A, Ferrer-Orta, C, Gonzalez, D, Rodriguez, J.F, Verdaguer, N.
登録日2007-08-23
公開日2008-02-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights into the multifunctional protein VP3 of birnaviruses.
Structure, 16, 2008
3HPO
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Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus Y714S mutant bound to G:T mismatch
分子名称: 5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DOC))-3', 5'-D(P*GP*GP*CP*GP*TP*GP*AP*TP*CP*G)-3', DNA polymerase I, ...
著者Wu, E.Y, Beese, L.S.
登録日2009-06-04
公開日2010-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
J.Biol.Chem., 286, 2011
4ED8
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Human DNA polymerase eta - DNA ternary complex: Reaction in the TG crystal at pH 7.0, Normal translocation
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*G)-3'), ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-27
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.521 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
4P4O
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Crystal structure of Leishmania infantum polymerase beta: Ternary gap complex
分子名称: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*TP*AP*T)-3'), DNA (5'-D(P*CP*GP*GP*CP*AP*AP*TP*AP*CP*TP*G)-3'), ...
著者Mejia, E, Burak, M, Alonso, A, Larraga, V, Kunkel, T, Bebenek, K, Garcia-Diaz, M.
登録日2014-03-12
公開日2014-08-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3001 Å)
主引用文献Structures of the Leishmania infantum polymerase beta.
DNA Repair (Amst.), 18, 2014
1IK1
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Solution Structure of an RNA Hairpin from HRV-14
分子名称: 5'-R(*GP*GP*UP*AP*CP*UP*AP*UP*GP*UP*AP*CP*CP*A)-3'
著者Huang, H, Alexandrov, A, Chen, X, Barnes III, T.W, Zhang, H, Dutta, K, Pascal, S.M.
登録日2001-05-01
公開日2001-07-18
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structure of an RNA hairpin from HRV-14.
Biochemistry, 40, 2001
3NAE
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RB69 DNA Polymerase (Y567A) Ternary Complex with dATP Opposite Guanidinohydantoin
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ...
著者Wang, M, Beckman, J, Blaha, G, Wang, J, Konigsberg, W.H.
登録日2010-06-01
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.003 Å)
主引用文献Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin .
Biochemistry, 49, 2010
1OQ0
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P6.1 stem loop from the activation domain of hTR
分子名称: P6.1 RNA hairpin from hTR
著者Leeper, T, Leulliot, N, Varani, G.
登録日2003-03-06
公開日2003-05-13
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The solution structure of an essential stem-loop of human telomerase RNA
NUCLEIC ACIDS RES., 31, 2003
4BPX
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Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase alpha
分子名称: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013

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