3GEY
Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment in complex with an inhibitor Pj34
Summary for 3GEY
Entry DOI | 10.2210/pdb3gey/pdb |
Related | 3BLJ |
Descriptor | Poly [ADP-ribose] polymerase 15, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE (3 entities in total) |
Functional Keywords | parp, poly(adp-ribose) polymerase, bal-3, sgc, structural genomics consortium, glycosyltransferase, nad, nucleus, transcription, transcription regulation, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q460N3 |
Total number of polymer chains | 4 |
Total formula weight | 102348.51 |
Authors | Karlberg, T.,Siponen, M.I.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kotenyova, T.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Schutz, P.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-02-26, release date: 2009-03-24, Last modification date: 2024-05-29) |
Primary citation | Karlberg, T.,Klepsch, M.,Thorsell, A.G.,Andersson, C.D.,Linusson, A.,Schuler, H. Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein. J.Biol.Chem., 290:7336-7344, 2015 Cited by PubMed: 25635049DOI: 10.1074/jbc.M114.630160 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report