7B5L
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![BU of 7b5l by Molmil](/molmil-images/mine/7b5l) | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 | 分子名称: | 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... | 著者 | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | 登録日 | 2020-12-04 | 公開日 | 2021-02-10 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
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6DJW
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![BU of 6djw by Molmil](/molmil-images/mine/6djw) | Crystal Structure of pParkin (REP and RING2 deleted)-pUb-UbcH7 complex | 分子名称: | RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... | 著者 | Sauve, V, Sung, G, Trempe, J.F, Gehring, K. | 登録日 | 2018-05-26 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.801 Å) | 主引用文献 | Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
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4DDI
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![BU of 4ddi by Molmil](/molmil-images/mine/4ddi) | |
8GRQ
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![BU of 8grq by Molmil](/molmil-images/mine/8grq) | Cryo-EM structure of BRCA1/BARD1 bound to H2AK127-UbcH5c-Ub nucleosome | 分子名称: | BRCA1-associated RING domain protein 1, Breast cancer type 1 susceptibility protein, DNA (147-MER), ... | 著者 | Ai, H.S, Zebin, T, Zhiheng, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | 登録日 | 2022-09-02 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination. Chem, 2023
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8UQD
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![BU of 8uqd by Molmil](/molmil-images/mine/8uqd) | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (condition 2. RING not modeled in density) | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.893 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN5
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![BU of 8sn5 by Molmil](/molmil-images/mine/8sn5) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 3) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN9
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![BU of 8sn9 by Molmil](/molmil-images/mine/8sn9) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with backside ubiquitin (UbcH5c chemically conjugated to histone H2A) (class 1) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8U14
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![BU of 8u14 by Molmil](/molmil-images/mine/8u14) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 2) | 分子名称: | DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-30 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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7JZV
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![BU of 7jzv by Molmil](/molmil-images/mine/7jzv) | Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome | 分子名称: | BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ... | 著者 | Witus, S.R, Burrell, A.L, Hansen, J.M, Farrell, D.P, Dimaio, F, Kollman, J.M, Klevit, R.E. | 登録日 | 2020-09-02 | 公開日 | 2021-02-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1. Nat.Struct.Mol.Biol., 28, 2021
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5VO0
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![BU of 5vo0 by Molmil](/molmil-images/mine/5vo0) | Structure of a TRAF6-Ubc13~Ub complex | 分子名称: | POTASSIUM ION, TNF receptor-associated factor 6, Ubiquitin, ... | 著者 | Middleton, A.J, Day, C.L. | 登録日 | 2017-05-01 | 公開日 | 2017-12-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1. Nat Commun, 8, 2017
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8TAR
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![BU of 8tar by Molmil](/molmil-images/mine/8tar) | APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | 登録日 | 2023-06-27 | 公開日 | 2023-09-27 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat.Struct.Mol.Biol., 30, 2023
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8SNA
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![BU of 8sna by Molmil](/molmil-images/mine/8sna) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with backside ubiquitin (UbcH5c chemically conjugated to histone H2A) (class 2) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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7KZV
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![BU of 7kzv by Molmil](/molmil-images/mine/7kzv) | |
7KZT
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![BU of 7kzt by Molmil](/molmil-images/mine/7kzt) | |
7KZS
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![BU of 7kzs by Molmil](/molmil-images/mine/7kzs) | |
5A31
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![BU of 5a31 by Molmil](/molmil-images/mine/5a31) | Structure of the human APC-Cdh1-Hsl1-UbcH10 complex. | 分子名称: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... | 著者 | Chang, L, Zhang, Z, Yang, J, Mclaughlin, S.H, Barford, D. | 登録日 | 2015-05-26 | 公開日 | 2015-11-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Atomic Structure of the Apc/C and its Mechanism of Protein Ubiquitination. Nature, 522, 2015
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7KZR
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![BU of 7kzr by Molmil](/molmil-images/mine/7kzr) | |
6Q83
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![BU of 6q83 by Molmil](/molmil-images/mine/6q83) | Crystal structure of the biportin Pdr6 in complex with UBC9 | 分子名称: | Importin beta-like protein KAP122, UBC9 | 著者 | Aksu, M, Trakhanov, S, Vera-Rodriguez, A, Gorlich, D. | 登録日 | 2018-12-14 | 公開日 | 2019-05-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4.53 Å) | 主引用文献 | Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
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6DJX
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![BU of 6djx by Molmil](/molmil-images/mine/6djx) | Crystal Structure of pParkin-pUb-UbcH7 complex | 分子名称: | RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... | 著者 | Sauve, V, Sung, G, Trempe, J.F, Gehring, K. | 登録日 | 2018-05-27 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (4.801 Å) | 主引用文献 | Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
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4ORH
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![BU of 4orh by Molmil](/molmil-images/mine/4orh) | Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer | 分子名称: | E3 ubiquitin-protein ligase RNF8, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2, ... | 著者 | Campbell, S.J, Edwards, R.A, Glover, J.N.M. | 登録日 | 2014-02-11 | 公開日 | 2014-02-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4.802 Å) | 主引用文献 | Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. J.Biol.Chem., 287, 2012
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5KHR
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![BU of 5khr by Molmil](/molmil-images/mine/5khr) | Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C) | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A. | 登録日 | 2016-06-15 | 公開日 | 2016-08-24 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol.Cell, 63, 2016
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8AUK
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![BU of 8auk by Molmil](/molmil-images/mine/8auk) | Cryo-EM structure of human BIRC6 in complex with HTRA2. | 分子名称: | Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial, ... | 著者 | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | 登録日 | 2022-08-25 | 公開日 | 2023-02-15 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
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5L9U
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![BU of 5l9u by Molmil](/molmil-images/mine/5l9u) | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | 登録日 | 2016-06-11 | 公開日 | 2016-09-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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5L9T
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![BU of 5l9t by Molmil](/molmil-images/mine/5l9t) | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | 登録日 | 2016-06-11 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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8ATX
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![BU of 8atx by Molmil](/molmil-images/mine/8atx) | |