PDB: 36667 件ウェブページステータス検索Chemie searchBIRD

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7Y8H	Crystal structure of sDscam FNIII1 domain, isoform alpha7 分子名称: Down Syndrome Cell Adhesion Molecules, SULFATE ION 著者 Chen, Q, Yu, Y, Cheng, J. 登録日 2022-06-23 公開日 2023-05-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the self-recognition of sDSCAM in Chelicerata. Nat Commun, 14, 2023
8A8M	Structure of the MAPK p38alpha in complex with its activating MAP2K MKK6 分子名称: Dual specificity mitogen-activated protein kinase kinase 6, MAGNESIUM ION, Mitogen-activated protein kinase 14, ... 著者 Bowler, M.W, Juyoux, P, Pellegrini, E. 登録日 2022-06-23 公開日 2022-07-13 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation. Science, 381, 2023
8DG6	Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors 分子名称: 1-{2-[(2S)-2-{[(3-chloro-2-fluorophenyl)methyl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl}-1H-indazole-3-carboxamide, Complement factor D 著者 Raman, K, Babu, Y.S. 登録日 2022-06-23 公開日 2022-11-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.986 Å) 主引用文献 Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. Bioorg.Med.Chem., 74, 2022
8DGA	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IV 分子名称: Endoribonuclease Dcr-1, Loquacious, isoform B, ... 著者 Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. 登録日 2022-06-23 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
8DG7	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex III 分子名称: Endoribonuclease Dcr-1, Loquacious, isoform B, ... 著者 Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. 登録日 2022-06-23 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
8DGJ	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex Ib 分子名称: Endoribonuclease Dcr-1, Loquacious, isoform B 著者 Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. 登録日 2022-06-23 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (4.02 Å) 主引用文献 Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
8DGI	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex Ia 分子名称: Endoribonuclease Dcr-1, Loquacious, isoform B 著者 Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. 登録日 2022-06-23 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.94 Å) 主引用文献 Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
8DG5	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IIb 分子名称: Endoribonuclease Dcr-1, Loquacious, isoform B, ... 著者 Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. 登録日 2022-06-23 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
8A8L	Crystal structure of a staphylococcal orthologue of CYP134A1 (CYPX) in complex with a heme-coordinated fragment 分子名称: 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, Cytochrome P450 protein, GLYCEROL, ... 著者 Snee, M, Katariya, M, Levy, C. 登録日 2022-06-23 公開日 2023-07-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Crystal structure of a staphylococcal orthologue of CYP134A1 (CYPX) in complex with a heme-coordinated fragment To Be Published
7Y7M	The structure of coxsackievirus A16 mature virion in complex with Fab 8C4 分子名称: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... 著者 Cong, Y, Liu, C.X. 登録日 2022-06-22 公開日 2022-08-24 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 Molecular mechanism of antibody neutralization of coxsackievirus A16. Nat Commun, 13, 2022
8DFV	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IIa 分子名称: CALCIUM ION, Endoribonuclease Dcr-1, Loquacious, ... 著者 Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. 登録日 2022-06-22 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
8DFM	Ectodomain of full-length wild-type KIT-SCF dimers 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... 著者 Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J. 登録日 2022-06-22 公開日 2023-03-29 最終更新日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
8DFQ	Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... 著者 Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J. 登録日 2022-06-22 公開日 2023-03-29 最終更新日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3.96 Å) 主引用文献 Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
8DFP	Ectodomain of full-length KIT(DupA502,Y503)-SCF dimers 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... 著者 Bertoletti, N, Krimmer, S.G, Mi, W, Schlessinger, J. 登録日 2022-06-22 公開日 2023-03-29 最終更新日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
7Y6M	Intracellular Subtilisin from Bacillus sp. 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Intracellular serine protease 著者 Hussin, N, Jamaluddin, H, Jonet, M.A. 登録日 2022-06-21 公開日 2022-07-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.703 Å) 主引用文献 Intracellular Subtilisin from Bacillus sp. TO BE PUBLISHED
8DEY	Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709 分子名称: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... 著者 Ma, X, Ornelas, E, Clifton, M.C. 登録日 2022-06-21 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023
7Y6E	Crystal structure of sDscam FNIII23 domains, isoform Beta2v6 分子名称: Dscam 著者 Chen, Q, Yu, Y, Cheng, J. 登録日 2022-06-20 公開日 2023-05-24 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.034 Å) 主引用文献 Structural basis for the self-recognition of sDSCAM in Chelicerata. Nat Commun, 14, 2023
8DEA	Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors 分子名称: 1-[(3-acetylphenyl)acetyl]-N-(6-bromopyridin-2-yl)-L-prolinamide, Complement factor D, GLYCEROL 著者 Raman, K, Babu, Y.S. 登録日 2022-06-20 公開日 2022-11-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.214 Å) 主引用文献 Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. Bioorg.Med.Chem., 74, 2022
8DE6	Oligomeric C9 in complex with aE11 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement component C9, ... 著者 Bayly-Jones, C. 登録日 2022-06-20 公開日 2023-01-25 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9. Commun Biol, 6, 2023
8A6W	Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with cholestenone 分子名称: (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, PROTOPORPHYRIN IX CONTAINING FE, Steroid C26-monooxygenase 著者 Snee, M, Amadi, C, Levy, C. 登録日 2022-06-20 公開日 2023-07-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with cholestenone To Be Published
8A7D	Partial dimer complex of PAPP-A and its inhibitor STC2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Pappalysin-1, ... 著者 Kobbero, S.D, Gajhede, M, Mirza, O.A, Boesen, T, Oxvig, C. 登録日 2022-06-20 公開日 2022-11-02 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism. Nat Commun, 13, 2022
8A7E	PAPP-A dimer in complex with its inhibitor STC2 分子名称: CALCIUM ION, Pappalysin-1, Stanniocalcin-2, ... 著者 Kobbero, S.D, Gajhede, M, Mirza, O.A, Boesen, T, Oxvig, C. 登録日 2022-06-20 公開日 2022-11-02 実験手法 ELECTRON MICROSCOPY (5.02 Å) 主引用文献 Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism. Nat Commun, 13, 2022
8DE5	Structure of glyceraldehyde-3-phosphate dehydrogenase from Paracoccidioides lutzii 分子名称: D-galactonic acid, GLYCEROL, Glyceraldehyde-3-phosphate dehydrogenase, ... 著者 Hernandez-Prieto, J.H, Martini, V.P, Iulek, J. 登録日 2022-06-19 公開日 2023-06-21 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structure of glyceraldehyde-3-phosphate dehydrogenase from Paracoccidioides lutzii in complex with an aldonic sugar acid. Biochimie, 218, 2023
7Y67	Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein 分子名称: C089 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. 登録日 2022-06-18 公開日 2023-03-01 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
7Y64	Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein 分子名称: C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. 登録日 2022-06-18 公開日 2023-03-01 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023

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