8A8M
Structure of the MAPK p38alpha in complex with its activating MAP2K MKK6
Summary for 8A8M
| Entry DOI | 10.2210/pdb8a8m/pdb |
| EMDB information | 15233 |
| Descriptor | Mitogen-activated protein kinase 14, Dual specificity mitogen-activated protein kinase kinase 6, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (4 entities in total) |
| Functional Keywords | kinase, signalling, map kinase, phosphoryl transfer, immune system |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 86418.25 |
| Authors | Bowler, M.W.,Juyoux, P.,Pellegrini, E. (deposition date: 2022-06-23, release date: 2022-07-13, Last modification date: 2023-09-27) |
| Primary citation | Juyoux, P.,Galdadas, I.,Gobbo, D.,von Velsen, J.,Pelosse, M.,Tully, M.,Vadas, O.,Gervasio, F.L.,Pellegrini, E.,Bowler, M.W. Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation. Science, 381:1217-1225, 2023 Cited by PubMed: 37708276DOI: 10.1126/science.add7859 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (4 Å) |
Structure validation
Download full validation report
