PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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4JOL	Complex structure of AML1-ETO NHR2 domain with HEB fragment 分子名称: Protein CBFA2T1, Transcription factor 12 著者 Wang, Z, Patel, D.J. 登録日 2013-03-18 公開日 2013-06-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.906 Å) 主引用文献 A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature, 500, 2013
2P9N	Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein 2, Actin-like protein 3, ... 著者 Nolen, B.J, Pollard, T.D. 登録日 2007-03-26 公開日 2007-05-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell, 26, 2007
2OVJ	The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP. 分子名称: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Rac GTPase-activating protein 1 著者 Shrestha, L, Papagrigoriou, E, Soundararajan, M, Elkins, J, Johansson, C, von Delft, F, Pike, A.C.W, Burgess, N, Turnbull, A, Debreczeni, J, Gorrec, F, Umeano, C, Edwards, A, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) 登録日 2007-02-14 公開日 2007-02-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP. To be Published
2P4N	Human Monomeric Kinesin (1BG2) and Bovine Tubulin (1JFF) Docked into the 9-Angstrom Cryo-EM Map of Nucleotide-Free Kinesin Complexed to the Microtubule 分子名称: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Sindelar, C.V, Downing, K.H. 登録日 2007-03-12 公開日 2008-07-08 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (9 Å) 主引用文献 The beginning of kinesin's force-generating cycle visualized at 9-A resolution. J.Cell Biol., 177, 2007
2OT1	Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with naphthol AS-E phosphate, a competitive inhibitor 分子名称: Fructose-bisphosphate aldolase A, N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE 著者 St-Jean, M, Izard, T, Sygusch, J. 登録日 2007-02-07 公開日 2007-02-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with wiskott-Aldrich syndrome protein. J.Biol.Chem., 282, 2007
2P9P	Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein 2, Actin-like protein 3, ... 著者 Nolen, B.J, Pollard, T.D. 登録日 2007-03-26 公開日 2007-05-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell, 26, 2007
4J8N	Aurora A Kinase Apo 分子名称: Aurora kinase A 著者 Meyerowitz, J.G, Gustafson, W.C, Shokat, K.M, Weiss, W.A. 登録日 2013-02-14 公開日 2014-09-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.135 Å) 主引用文献 Drugging MYCN through an Allosteric Transition in Aurora Kinase A. Cancer Cell, 26, 2014
4JAJ	Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE 分子名称: Aurora kinase A, benzo[c][1,8]naphthyridin-6(5H)-one 著者 Jiang, X, Josephson, K, Huck, B, Goutopoulos, A, Karra, S. 登録日 2013-02-18 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
2OO1	Crystal structure of the Bromo domain 2 of human Bromodomain containing protein 3 (BRD3) 分子名称: 1,2-ETHANEDIOL, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Bromodomain-containing protein 3, ... 著者 Filippakopoulos, P, Bullock, A, Papagrigoriou, E, Keates, T, Cooper, C, Smee, C, Ugochukwu, E, Debreczeni, J, von Delft, F, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2007-01-25 公開日 2007-02-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
4JBQ	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules 分子名称: Aurora Kinase A, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE 著者 Wu, J.S, Leou, J.S, Peng, Y.H, Hsueh, C.C, Hsieh, H.P, Wu, S.Y. 登録日 2013-02-20 公開日 2013-06-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc.Natl.Acad.Sci.USA, 110, 2013
4JEF	Crystal structure of human thymidylate synthase Y202A in inactive conformation. 分子名称: SULFATE ION, Thymidylate synthase 著者 Tochowicz, A, Stroud, R.M, Wade, R.C. 登録日 2013-02-26 公開日 2014-08-20 最終更新日 2015-05-06 実験手法 X-RAY DIFFRACTION (2.311 Å) 主引用文献 Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015
2Q8K	The crystal structure of Ebp1 分子名称: GLYCEROL, Proliferation-associated protein 2G4, SULFATE ION 著者 Kowalinski, E, Bange, G, Wild, K, Sinning, I. 登録日 2007-06-11 公開日 2007-09-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. Febs Lett., 581, 2007
4GV7	Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328 分子名称: 2-methylquinazolin-4(3H)-one, Poly [ADP-ribose] polymerase 1 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2012-08-30 公開日 2013-06-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 Acs Chem.Biol., 8, 2013
4HAT	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
2N1B	NMR solution structure of nucleotide-free Ran GTPase 分子名称: GTP-binding nuclear protein Ran 著者 Bacot-Davis, V.R, Palmenberg, A.C. 登録日 2015-03-26 公開日 2016-04-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NMR Structure of Ran GTPase Determines C-terminal Tail Conformational Dynamics. To be Published
2NA1	ULD complex 分子名称: Polycomb complex protein BMI-1, Polyhomeotic-like 2 著者 Cierpicki, T, Gray, F, Cho, H. 登録日 2015-12-17 公開日 2016-11-16 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization. Nat Commun, 7, 2016
4J8M	Aurora A in complex with CD532 分子名称: 1,2-ETHANEDIOL, 1-[4-[[4-[(5-cyclopentyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea, Aurora kinase A, ... 著者 Meyerowitz, J.G, Gustafson, W.C, Shokat, K.M, Weiss, W.A. 登録日 2013-02-14 公開日 2014-09-10 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.853 Å) 主引用文献 Drugging MYCN through an Allosteric Transition in Aurora Kinase A. Cancer Cell, 26, 2014
4JBP	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules 分子名称: 1-(4-{2-[(6-{4-[2-(4-hydroxypiperidin-1-yl)ethoxy]phenyl}furo[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea, Aurora Kinase A 著者 Wu, J.S, Leou, J.S, Peng, Y.H, Hsueh, C.C, Hsieh, H.P, Wu, S.Y. 登録日 2013-02-20 公開日 2013-06-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc.Natl.Acad.Sci.USA, 110, 2013
4JNK	Lactate Dehydrogenase A in complex with inhibitor compound 22 分子名称: (2R)-2-{[5-cyano-4-(3,4-dichlorophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)propanamide, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Eigenbrot, C, Ultsch, M. 登録日 2013-03-15 公開日 2013-05-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.896 Å) 主引用文献 Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 23, 2013
2ND0	Solution NMR structures of BRD4 ET domain with LANA peptide 分子名称: Bromodomain-containing protein 4, LANA 著者 Zeng, L, Zhou, M. 登録日 2016-04-18 公開日 2016-06-29 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4. Structure, 24, 2016
2N80	p75NTR DD:RhoGDI 分子名称: Rho GDP-dissociation inhibitor 1, Tumor necrosis factor receptor superfamily member 16 著者 Lin, Z, Ibanez, C.F. 登録日 2015-09-30 公開日 2015-12-23 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural basis of death domain signaling in the p75 neurotrophin receptor Elife, 4, 2015
2NCZ	Solution NMR structures of BRD4 ET domain in complex with NSD3_1 peptide 分子名称: Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3 著者 Zeng, L, Zhou, M. 登録日 2016-04-18 公開日 2016-06-29 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4. Structure, 24, 2016
2QUV	Phosphate ions in fructose-1,6-bisphosphate aldolase from rabbit muscle 分子名称: Fructose-bisphosphate aldolase A, PHOSPHATE ION 著者 St-Jean, M, Sygusch, J. 登録日 2007-08-06 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Stereospecific proton transfer by a mobile catalyst in mammalian fructose-1,6-bisphosphate aldolase J.Biol.Chem., 282, 2007
2NLU	Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor 分子名称: Hepatoma-derived growth factor 著者 Sue, S.C, Lee, W.T, Huang, T.H. 登録日 2006-10-20 公開日 2007-09-04 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 PWWP module of human hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparin J.Mol.Biol., 367, 2007
2N3K	Human Brd4 ET domain in complex with MLV Integrase C-term 分子名称: Bromodomain-containing protein 4, MLV integrase 著者 Crowe, B.L, Foster, M.P. 登録日 2015-06-03 公開日 2016-03-02 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structure of the Brd4 ET domain bound to a C-terminal motif from gamma-retroviral integrases reveals a conserved mechanism of interaction. Proc.Natl.Acad.Sci.USA, 113, 2016

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