8GKH
 
 | | Structure of the Spizellomyces punctatus Fanzor (SpuFz) in complex with omega RNA and target DNA | | 分子名称: | DNA (35-MER), DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), MAGNESIUM ION, ... | | 著者 | Xu, P, Saito, M, Zhang, F. | | 登録日 | 2023-03-19 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Fanzor is a eukaryotic programmable RNA-guided endonuclease.
Nature, 620, 2023
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5GMT
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7PLO
 | | H. sapiens replisome-CUL2/LRR1 complex | | 分子名称: | Cell division control protein 45 homolog, Claspin, Cullin-2, ... | | 著者 | Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M. | | 登録日 | 2021-09-01 | | 公開日 | 2021-11-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
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5GVD
 | | Human TDRD3 DUF1767-OB domains | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Goto-Ito, S, Yamagata, A, Sato, Y, Takahashi, T.S, Fukai, S. | | 登録日 | 2016-09-05 | | 公開日 | 2017-06-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.623 Å) | | 主引用文献 | Structural basis of the interaction between Topoisomerase III beta and the TDRD3 auxiliary factor
Sci Rep, 7, 2017
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5ETH
 | | RORy in complex with inverse agonist 3. | | 分子名称: | 1-methyl-~{N}-(1-thiophen-2-ylcarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)-~{N}-[2,2,2-tris(fluoranyl)ethyl]indole-4-sulfonamide, Nuclear receptor ROR-gamma | | 著者 | Marcotte, D.M. | | 登録日 | 2015-11-17 | | 公開日 | 2016-04-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | | 主引用文献 | Discovery of biaryls as ROR gamma inverse agonists by using structure-based design.
Bioorg.Med.Chem.Lett., 26, 2016
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1DZB
 | | Crystal structure of phage library-derived single-chain Fv fragment 1F9 in complex with turkey egg-white lysozyme | | 分子名称: | SCFV FRAGMENT 1F9, TURKEY EGG-WHITE LYSOZYME C | | 著者 | Ay, J, Keitel, T, Kuettner, G, Wessner, H, Scholz, C, Hahn, M, Hoehne, W. | | 登録日 | 2000-02-23 | | 公開日 | 2000-11-02 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of a Phage Library-Derived Single-Chain Fv Fragment Complexed with Turkey Egg -White Lysozyme at 2.0 A Resolution
J.Mol.Biol., 301, 2000
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5NNZ
 | | Crystal structure of human ODA16 | | 分子名称: | Dynein assembly factor with WDR repeat domains 1 | | 著者 | Lorentzen, E, Taschner, T, Basquin, J. | | 登録日 | 2017-04-10 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.651 Å) | | 主引用文献 | Purification and crystal structure of human ODA16: Implications for ciliary import of outer dynein arms by the intraflagellar transport machinery.
Protein Sci., 29, 2020
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5GVE
 | | Human TOP3B-TDRD3 complex | | 分子名称: | DNA topoisomerase 3-beta-1, MAGNESIUM ION, Tudor domain-containing protein 3 | | 著者 | Goto-Ito, S, Yamagata, A, Sato, Y, Takahashi, T.S, Fukai, S. | | 登録日 | 2016-09-05 | | 公開日 | 2017-06-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.606 Å) | | 主引用文献 | Structural basis of the interaction between Topoisomerase III beta and the TDRD3 auxiliary factor
Sci Rep, 7, 2017
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5GW4
 | | Structure of Yeast NPP-TRiC | | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | | 著者 | Zang, Y, Jin, M, Wang, H, Cong, Y. | | 登録日 | 2016-09-08 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.
Nat. Struct. Mol. Biol., 23, 2016
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3J8C
 | | Model of the human eIF3 PCI-MPN octamer docked into the 43S EM map | | 分子名称: | Eukaryotic translation initiation factor 3 subunit A, Eukaryotic translation initiation factor 3 subunit C, Eukaryotic translation initiation factor 3 subunit E, ... | | 著者 | Erzberger, J.P, Ban, N. | | 登録日 | 2014-10-08 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (11.6 Å) | | 主引用文献 | Molecular Architecture of the 40SeIF1eIF3 Translation Initiation Complex.
Cell(Cambridge,Mass.), 158, 2014
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5EBK
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5GW5
 | | Structure of TRiC-AMP-PNP | | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | | 著者 | Zang, Y, Jin, M, Wang, H, Cong, Y. | | 登録日 | 2016-09-08 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.
Nat. Struct. Mol. Biol., 23, 2016
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5E4R
 | | Crystal structure of domain-duplicated synthetic class II ketol-acid reductoisomerase 2Ia_KARI-DD | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Ketol-acid reductoisomerase, ... | | 著者 | Cahn, J.K.B, Brinkmann-Chen, S, Buller, A.R, Arnold, F.H. | | 登録日 | 2015-10-07 | | 公開日 | 2015-12-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases.
Protein Sci., 25, 2016
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3X37
 | | Crystal structure of the N-terminal domain of Sld7 in complex with Sld3 | | 分子名称: | GLYCEROL, Mitochondrial morphogenesis protein SLD7, ZYRO0C14696p | | 著者 | Itou, H, Araki, H, Shirakihara, Y. | | 登録日 | 2015-01-16 | | 公開日 | 2015-08-19 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3.
Acta Crystallogr.,Sect.D, 71, 2015
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3BL3
 | | tRNA guanine transglycosylase V233G mutant apo structure | | 分子名称: | GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION | | 著者 | Tidten, N, Heine, A, Reuter, K, Klebe, G. | | 登録日 | 2007-12-10 | | 公開日 | 2008-12-16 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor
Plos One, 8, 2013
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2XYF
 | | HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents | | 分子名称: | METHYL N-[(2S)-1-[2-[(4R)-5-[[(2S)-3,3-DIMETHYL-1-METHYLAMINO-1-OXO-BUTAN-2-YL]AMINO]-4-HYDROXY-5-OXO-4-(PHENYLMETHYL)PENTYL]-2-[(4-THIOPHEN-3-YLPHENYL)METHYL]HYDRAZINYL]-3,3-DIMETHYL-1-OXO-BUTAN-2-YL]CARBAMATE, PROTEASE | | 著者 | Ohrngren, P, Wu, X, Persson, M, Ekegren, J.K, Wallberg, H, Rosenquist, A, Samuelsson, B, Unge, T, Larhed, M. | | 登録日 | 2010-11-17 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | HIV-1 Protease Inhibitors with a Tertiary Alcohol Containing Transition-State Mimic and Various P2 and P1' Substituents
Med.Chem.Commun., 2, 2011
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2XYE
 | | HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents | | 分子名称: | METHYL N-[(2S)-1-[2-[(4R)-5-[[(2S)-3,3-DIMETHYL-1-METHYLAMINO-1-OXO-BUTAN-2-YL]AMINO]-4-HYDROXY-5-OXO-4-(PHENYLMETHYL)PENTYL]-2-[(4-PHENYLPHENYL)METHYL]HYDRAZINYL]-3,3-DIMETHYL-1-OXO-BUTAN-2-YL]CARBAMATE, PROTEASE | | 著者 | Ohrngren, P, Wu, X, Persson, M, Ekegren, J.K, Wallberg, H, Rosenquist, A, Samuelsson, B, Unge, T, Larhed, M. | | 登録日 | 2010-11-17 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | HIV-1 Protease Inhibitors with a Tertiary Alcohol Containing Transition-State Mimic and Various P2 and P1' Substituents
Med.Chem.Commun., 2, 2011
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3EPL
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5HFY
 | | Backbone Modifications in the Protein GB1 Helix: beta-2-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35 | | 分子名称: | Immunoglobulin G-binding protein G | | 著者 | Tavenor, N.A, Reinert, Z.E, Lengyel, G.A, Griffith, B.D, Horne, W.S. | | 登録日 | 2016-01-07 | | 公開日 | 2016-02-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Comparison of design strategies for alpha-helix backbone modification in a protein tertiary fold.
Chem.Commun.(Camb.), 52, 2016
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5HG2
 | | Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-2-Asn35 | | 分子名称: | GLYCEROL, Immunoglobulin G-binding protein G, MAGNESIUM ION | | 著者 | Tavenor, N.A, Reinert, Z.E, Lengyel, G.A, Griffith, B.D, Horne, W.S. | | 登録日 | 2016-01-07 | | 公開日 | 2016-02-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Comparison of design strategies for alpha-helix backbone modification in a protein tertiary fold.
Chem.Commun.(Camb.), 52, 2016
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2OJV
 | | Crystal structure of a ternary complex of goat lactoperoxidase with cyanide and iodide ions at 2.4 A resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CARBONATE ION, ... | | 著者 | Singh, A.K, Singh, N, Singh, S.B, Sharma, S, Kaur, P, Singh, T.P. | | 登録日 | 2007-01-15 | | 公開日 | 2007-01-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of a ternary complex of goat lactoperoxidase with cyanide and iodide ions at 2.4 A resolution
To be Published
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3EPH
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5GIQ
 | | Xaa-Pro peptidase from Deinococcus radiodurans, Zinc bound | | 分子名称: | PHOSPHATE ION, Proline dipeptidase, ZINC ION | | 著者 | Are, V.N, Singh, R, Kumar, A, Ghosh, B, Jamdar, S.N, Makde, R.D. | | 登録日 | 2016-06-24 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures and activities of widely conserved small prokaryotic aminopeptidases-P clarify classification of M24B peptidases.
Proteins, 2018
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5G3M
 | | Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor. | | 分子名称: | 4-BENZYLBENZAMIDE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sandmark, J, Bodin, C, Hallberg, K. | | 登録日 | 2016-04-29 | | 公開日 | 2016-09-14 | | 最終更新日 | 2018-04-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of Azd2716: A Novel Secreted Phospholipase A2 (Spla2) Inhibitor for the Treatment of Coronary Artery Disease
Acs Med.Chem.Lett., 7, 2016
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5GAL
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