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8THK
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Cryo-EM structure of A61603-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein
分子名称: Endolysin,Alpha-1A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Su, M, Huang, X.Y.
登録日2023-07-17
公開日2023-08-16
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural basis of agonist specificity of alpha 1A -adrenergic receptor.
Nat Commun, 14, 2023
8THJ
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Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (antiparallel dimer)
分子名称: (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ...
著者Davies, J.S, Currie, M.C, Dobson, R.C.J, North, R.A.
登録日2023-07-16
公開日2023-11-22
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.
Elife, 12, 2024
8THI
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Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (parallel dimer)
分子名称: (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, SODIUM ION, Sialic acid TRAP transporter permease protein SiaT
著者Davies, J.S, Currie, M.C, Dobson, R.C.J, North, R.A.
登録日2023-07-16
公開日2023-11-22
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.
Elife, 12, 2024
8THH
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BU of 8thh by Molmil
Cryo-EM structure of Nav1.7 with LTG
分子名称: (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
著者Fan, X, Huang, J, Yan, N.
登録日2023-07-16
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine.
Proc.Natl.Acad.Sci.USA, 120, 2023
8THG
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Cryo-EM structure of Nav1.7 with RLZ
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Fan, X, Huang, J, Yan, N.
登録日2023-07-16
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine.
Proc.Natl.Acad.Sci.USA, 120, 2023
8THF
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BU of 8thf by Molmil
SARS-CoV-2 BA.1 S-6P-no-RBD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1,Spike glycoprotein
著者Bu, F, Li, F, Liu, B.
登録日2023-07-15
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献cryo-EM structure of SARS-CoV-2 BA.1 spike with RBD truncated
To Be Published
8THE
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Cryo-EM structure of Pseudomonas aeruginosa TonB-dependent transporter PhuR in complex with synthetic antibody and heme
分子名称: (2~{R},4~{R},5~{S},6~{S})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{R},4~{R},5~{S},6~{S})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{S})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Heme/hemoglobin uptake outer membrane receptor PhuR, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Knejski, P, Erramilli, S.K, Kossiakoff, A.A.
登録日2023-07-15
公開日2024-01-31
最終更新日2024-04-17
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding.
Structure, 32, 2024
8THD
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Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to PCNA
分子名称: ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ...
著者Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H.
登録日2023-07-14
公開日2024-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Structure of the PCNA unloader Elg1-RFC.
Sci Adv, 10, 2024
8THC
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Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to a cracked PCNA
分子名称: ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ...
著者Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H.
登録日2023-07-14
公開日2024-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.67 Å)
主引用文献Structure of the PCNA unloader Elg1-RFC.
Sci Adv, 10, 2024
8THB
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BU of 8thb by Molmil
Structure of the Saccharomyces cerevisiae PCNA clamp unloader Elg1-RFC complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ...
著者Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H.
登録日2023-07-14
公開日2024-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the PCNA unloader Elg1-RFC.
Sci Adv, 10, 2024
8THA
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BU of 8tha by Molmil
1TEL, non-compressed, double-helical crystal form
分子名称: Transcription factor ETV6,Activated CDC42 kinase 1
著者Smith, C.P, Wilson, E.W, Pedroza Romo, M.J, Averett, J.C, Moody, J.D.
登録日2023-07-14
公開日2023-08-23
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献1TEL, non-compressed, double-helical crystal form
To Be Published
8TH9
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Structure of mammalian NEIL2 from Monodelphis domestica in complex with THF-containing DNA
分子名称: DIMETHYL SULFOXIDE, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3'), ...
著者Eckenroth, B.E, Doublie, S.
登録日2023-07-14
公開日2023-11-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Structural and biochemical insights into NEIL2's preference for abasic sites.
Nucleic Acids Res., 51, 2023
8TH8
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BU of 8th8 by Molmil
Linker domain of Nexin-dynein regulatory complex from Tetrahymena thermophila
分子名称: AAA family ATPase CDC48 subfamily protein, Calmodulin 7-2, Coiled-coil domain-containing protein 153, ...
著者Ghanaeian, A.G, Bui, K.H.
登録日2023-07-14
公開日2023-09-20
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (7.4 Å)
主引用文献Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism.
Nat Commun, 14, 2023
8TH7
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Crystal Structure of the G3BP1 NTF2-like domain bound to the Caprin1 peptide
分子名称: Caprin-1, Ras GTPase-activating protein-binding protein 1
著者Hughes, M.P, Taylor, J.P, Yang, Z.
登録日2023-07-14
公開日2024-03-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
8TH6
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Crystal Structure of the G3BP1 NTF2-like domain bound to USP10 peptide
分子名称: 1,2-ETHANEDIOL, Ras GTPase-activating protein-binding protein 1, Ubiquitin carboxyl-terminal hydrolase 10
著者Hughes, M.P, Taylor, J.P, Yang, Z.
登録日2023-07-14
公開日2024-03-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
8TH5
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BU of 8th5 by Molmil
Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein P13L mutant
分子名称: Nucleoprotein, Ras GTPase-activating protein-binding protein 1
著者Hughes, M.P, Taylor, J.P, Yang, Z.
登録日2023-07-13
公開日2024-03-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
8TH4
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BU of 8th4 by Molmil
Structure of AT118-L Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor and Losartan
分子名称: AT118-L Nanobody, BAG2 Anti-BRIL Fab Heavy Chain, BAG2 Anti-BRIL Fab Light Chain, ...
著者Skiba, M.A, Kruse, A.C.
登録日2023-07-13
公開日2024-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Antibodies expand the scope of angiotensin receptor pharmacology.
Nat.Chem.Biol., 2024
8TH3
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BU of 8th3 by Molmil
Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
分子名称: AT118-H nanobody, Type-1 angiotensin II receptor, Soluble cytochrome b562 complex, ...
著者Skiba, M.A, Kruse, A.C.
登録日2023-07-13
公開日2024-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Antibodies expand the scope of angiotensin receptor pharmacology.
Nat.Chem.Biol., 2024
8TH2
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BU of 8th2 by Molmil
Structure of the isoflavene-forming dirigent protein PsPTS2
分子名称: Dirigent protein
著者Smith, C.A, Meng, Q, Lewis, N.G, Davin, L.B.
登録日2023-07-13
公開日2024-01-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Dirigent isoflavene-forming PsPTS2: 3D structure, stereochemical, and kinetic characterization comparison with pterocarpan-forming PsPTS1 homolog in pea.
J.Biol.Chem., 300, 2024
8TH1
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Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein D3L mutant
分子名称: Nucleoprotein, Ras GTPase-activating protein-binding protein 1
著者Hughes, M.P, Taylor, J.P, Yang, Z.
登録日2023-07-13
公開日2023-12-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
8TGY
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BU of 8tgy by Molmil
Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in complex with guanylurea
分子名称: DECYL-BETA-D-MALTOPYRANOSIDE, L10 Monobody, LAURYL DIMETHYLAMINE-N-OXIDE, ...
著者Lucero, R.M, Stockbridge, R.B.
登録日2023-07-13
公開日2023-08-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Transport of metformin metabolites by guanidinium exporters of the Small Multidrug Resistance family.
Biorxiv, 2023
8TGT
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Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein
分子名称: 1,2-ETHANEDIOL, C4b-binding protein alpha chain, CALCIUM ION, ...
著者Kolesinski, P, Ghosh, P.
登録日2023-07-13
公開日2024-07-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein
To Be Published
8TGP
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Crystal structure of SIRT2 with FAM-PEG4-H4K16(myristoyl) peptide
分子名称: H4K16(myristoyl) peptide, MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, ...
著者Nicely, N.I, Weiser, B.P.
登録日2023-07-12
公開日2024-01-24
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Effects of Dimerization on the Deacylase Activities of Human SIRT2.
Biochemistry, 62, 2023
8TGO
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Crystal structure of the BG505 triple tandem trimer gp140 HIV-1 Env in complex with PGT124 and 35O22
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv, ...
著者Xian, Y, Yuan, M, Wilson, I.A.
登録日2023-07-12
公開日2024-04-17
実験手法X-RAY DIFFRACTION (5.75 Å)
主引用文献Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines.
Npj Vaccines, 9, 2024
8TGN
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VMAT1 dimer with serotonin and reserpine
分子名称: Chromaffin granule amine transporter, SEROTONIN, reserpine
著者Ye, J, Liu, B, Li, W.
登録日2023-07-12
公開日2024-03-20
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024

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件を2024-07-17に公開中

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