8TH1
Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein D3L mutant
Summary for 8TH1
Entry DOI | 10.2210/pdb8th1/pdb |
Descriptor | Ras GTPase-activating protein-binding protein 1, Nucleoprotein (3 entities in total) |
Functional Keywords | ntf2l covid, peptide binding protein, hydrolase-viral protein complex, hydrolase/viral protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 84482.87 |
Authors | Hughes, M.P.,Taylor, J.P.,Yang, Z. (deposition date: 2023-07-13, release date: 2023-12-27, Last modification date: 2024-05-08) |
Primary citation | Yang, Z.,Johnson, B.A.,Meliopoulos, V.A.,Ju, X.,Zhang, P.,Hughes, M.P.,Wu, J.,Koreski, K.P.,Clary, J.E.,Chang, T.C.,Wu, G.,Hixon, J.,Duffner, J.,Wong, K.,Lemieux, R.,Lokugamage, K.G.,Alvarado, R.E.,Crocquet-Valdes, P.A.,Walker, D.H.,Plante, K.S.,Plante, J.A.,Weaver, S.C.,Kim, H.J.,Meyers, R.,Schultz-Cherry, S.,Ding, Q.,Menachery, V.D.,Taylor, J.P. Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity. Cell Rep, 43:113965-113965, 2024 Cited by PubMed: 38492217DOI: 10.1016/j.celrep.2024.113965 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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