8TH4

Structure of AT118-L Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor and Losartan

Summary for 8TH4

• Entry DOI: 10.2210/pdb8th4/pdb
• EMDB information: 41248 41249
• Descriptor: Type-1 angiotensin II receptor Soluble cytochrome b562 complex, BAG2 Anti-BRIL Fab Heavy Chain, BAG2 Anti-BRIL Fab Light Chain, ... (5 entities in total)
• Functional Keywords: g protein-coupled receptor, nanobody, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 113349.51

Authors

Skiba, M.A.,Kruse, A.C. (deposition date: 2023-07-13, release date: 2024-05-22, Last modification date: 2024-05-29)

• Primary citation: Skiba, M.A.,Sterling, S.M.,Rawson, S.,Zhang, S.,Xu, H.,Jiang, H.,Nemeth, G.R.,Gilman, M.S.A.,Hurley, J.D.,Shen, P.,Staus, D.P.,Kim, J.,McMahon, C.,Lehtinen, M.K.,Rockman, H.A.,Barth, P.,Wingler, L.M.,Kruse, A.C.; Antibodies expand the scope of angiotensin receptor pharmacology.; Nat.Chem.Biol., 2024; PubMed: 38744986; DOI: 10.1038/s41589-024-01620-6

Experimental method

ELECTRON MICROSCOPY (3.3 Å)