8TH5

Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein P13L mutant

Summary for 8TH5

• Entry DOI: 10.2210/pdb8th5/pdb
• Descriptor: Ras GTPase-activating protein-binding protein 1, Nucleoprotein (3 entities in total)
• Functional Keywords: ntf2l usp10, peptide binding protein, hydrolase-viral protein complex, hydrolase/viral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 17
• Total formula weight: 177350.25

Authors

Hughes, M.P.,Taylor, J.P. (deposition date: 2023-07-13, release date: 2024-03-20, Last modification date: 2024-04-10)

• Primary citation: Yang, Z.,Johnson, B.A.,Meliopoulos, V.A.,Ju, X.,Zhang, P.,Hughes, M.P.,Wu, J.,Koreski, K.P.,Clary, J.E.,Chang, T.C.,Wu, G.,Hixon, J.,Duffner, J.,Wong, K.,Lemieux, R.,Lokugamage, K.G.,Alvarado, R.E.,Crocquet-Valdes, P.A.,Walker, D.H.,Plante, K.S.,Plante, J.A.,Weaver, S.C.,Kim, H.J.,Meyers, R.,Schultz-Cherry, S.,Ding, Q.,Menachery, V.D.,Taylor, J.P.; Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.; Cell Rep, 43:113965-113965, 2024; PubMed: 38492217; DOI: 10.1016/j.celrep.2024.113965

Experimental method

X-RAY DIFFRACTION (2.62 Å)