PDB: 47120 件ウェブページステータス検索Chemie searchBIRD

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7NHI	Crystal structure of the human METTL3-METTL14 complex with compound UOZ004 分子名称: (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl)piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... 著者 Bedi, R.K, Huang, D, Caflisch, A. 登録日 2021-02-10 公開日 2021-09-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
6DZ6	Structure of the Orthorhombic (Orthrhmb) Crystal Form of Human Apolipoprotein C1 分子名称: Apolipoprotein C-I 著者 McPherson, A. 登録日 2018-07-03 公開日 2018-12-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure of human apolipoprotein C-1 in four different crystal forms. J. Lipid Res., 60, 2019
7NCX	Crystal structure of GH30 (double mutant EE) from Thermothelomyces thermophila. 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... 著者 Dimarogona, M, Nikolaivits, E, Topakas, E, Weiss, M, Feiler, C.G. 登録日 2021-01-29 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies Carbohydrate Polymers, 273, 2021
4KR4	Salmonella typhi OmpF complex with Ampicillin 分子名称: (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, Outer membrane protein F 著者 Madhuranayaki, T, Balasubramaniam, D, Krishnaswamy, S. 登録日 2013-05-16 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Salmonella typhi OmpF complex with Ampicillin To be published
6E10	PTEX Core Complex in the Engaged (Extended) State 分子名称: Endogenous cargo polypeptide, Exported protein 2, Heat shock protein 101, ... 著者 Ho, C, Lai, M, Zhou, Z.H. 登録日 2018-07-08 公開日 2018-08-22 最終更新日 2019-11-27 実験手法 ELECTRON MICROSCOPY (4.16 Å) 主引用文献 Malaria parasite translocon structure and mechanism of effector export. Nature, 561, 2018
8F7B	LRRC8A(T48D):C conformation 2 top focus 分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C 著者 Kern, D.M, Brohawn, S.G. 登録日 2022-11-18 公開日 2023-03-08 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
7N7W	Crystal Structure of SARS-CoV-2 NendoU in complex with CSC000178569 分子名称: N-(2-fluorophenyl)-N'-methylurea, Uridylate-specific endoribonuclease 著者 Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G. 登録日 2021-06-11 公開日 2021-09-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 51, 2023
8S94	Structure of C-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA helicase MCM8, DNA helicase MCM9, ... 著者 Li, C, Gao, Y. 登録日 2023-03-27 公開日 2023-06-07 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3.94 Å) 主引用文献 Activity, substrate preference and structure of the HsMCM8/9 helicase. Nucleic Acids Res., 51, 2023
7N83	Crystal Structure of SARS-CoV-2 NendoU in complex with Z2443429438 分子名称: (3S)-1-(phenylsulfonyl)pyrrolidin-3-amine, CITRIC ACID, Uridylate-specific endoribonuclease 著者 Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G. 登録日 2021-06-12 公開日 2021-09-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 51, 2023
6E07	Crystal structure of Canton G6PD in complex with structural NADP 分子名称: GLYCEROL, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Rahighi, S, Mochly-Rosen, D, Wakatsuki, S. 登録日 2018-07-06 公開日 2018-07-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nat Commun, 9, 2018
6E1Y	Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design 分子名称: N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide, WD repeat-containing protein 5 著者 Phan, J, Fesik, S.W. 登録日 2018-07-10 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.219 Å) 主引用文献 Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
7NH4	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 3 分子名称: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2021-02-10 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
8F77	LRRC8A(T48D):C conformation 2 top focus 分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C 著者 Kern, D.M, Brohawn, S.G. 登録日 2022-11-18 公開日 2023-03-08 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
7N7U	Crystal Structure of SARS-CoV-2 NendoU in complex with LIZA-7 分子名称: 1-[(2~{R},4~{S},5~{R})-5-[[(azanylidene-$l^{4}-azanylidene)amino]methyl]-4-oxidanyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione, Uridylate-specific endoribonuclease 著者 Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G. 登録日 2021-06-11 公開日 2021-09-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 51, 2023
4KOQ	Crystal Structure of WHY3 from Arabidopsis thaliana 分子名称: PHOSPHATE ION, Single-stranded DNA-binding protein WHY3, chloroplastic 著者 Cappadocia, L, Parent, J.S, Brisson, N, Sygusch, J. 登録日 2013-05-12 公開日 2013-11-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A family portrait: structural comparison of the Whirly proteins from Arabidopsis thaliana and Solanum tuberosum. Acta Crystallogr.,Sect.F, 69, 2013
7NH5	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 6 分子名称: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-methyl-6-[4-[[4-[2-oxidanylidene-6-(propanoylamino)-3~{H}-benzimidazol-1-yl]piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carboxamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2021-02-10 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
8F74	LRRC8A(T48D):C conformation 2 top focus 分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C 著者 Kern, D.M, Brohawn, S.G. 登録日 2022-11-18 公開日 2023-03-08 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
8S92	Structure of N-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP 分子名称: DNA helicase MCM8, DNA helicase MCM9 著者 Li, C, Gao, Y. 登録日 2023-03-27 公開日 2023-06-07 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (4.06 Å) 主引用文献 Activity, substrate preference and structure of the HsMCM8/9 helicase. Nucleic Acids Res., 51, 2023
6E0B	Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1 分子名称: 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Tomchick, D.R, Phillips, M.A, Deng, X. 登録日 2018-07-06 公開日 2018-11-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis, 5, 2019
8S91	Structure of Walker B mutated MCM8/9 heterohexamer complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA helicase MCM8, DNA helicase MCM9, ... 著者 Li, C, Gao, Y. 登録日 2023-03-27 公開日 2023-06-07 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Activity, substrate preference and structure of the HsMCM8/9 helicase. Nucleic Acids Res., 51, 2023
6E06	Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate solved by precipitant-ligand exchange (crystals grown in citrate precipitant) 分子名称: ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION 著者 Thompson, A.P, Wegener, K.L, Bruning, J.B, Polyak, S.W. 登録日 2018-07-06 公開日 2018-10-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase. Acta Crystallogr D Struct Biol, 74, 2018
7N7R	Crystal Structure of SARS-CoV-2 NendoU in complex with Z2472938267 分子名称: 1-[2-(2-oxidanylidenepyrrolidin-1-yl)ethyl]-3-phenyl-urea, Uridylate-specific endoribonuclease 著者 Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G. 登録日 2021-06-11 公開日 2021-09-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 51, 2023
7N7Y	Crystal Structure of SARS-CoV-2 NendoU in complex with Z18197050 分子名称: Uridylate-specific endoribonuclease, methyl 4-sulfamoylbenzoate 著者 Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G. 登録日 2021-06-11 公開日 2021-09-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 51, 2023
8SRZ	Structure of a bacterial death-like domain from Lysobacter enzymogenes 分子名称: Probable serine protease FE772_23065 著者 Johnson, A.G, Kranzusch, P.J. 登録日 2023-05-08 公開日 2023-06-07 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 CARD-like domains mediate anti-phage defense in bacterial gasdermin systems. Biorxiv, 2023
4KQE	The mutant structure of the human glycyl-tRNA synthetase E71G 分子名称: GLYCEROL, Glycine--tRNA ligase 著者 Qin, X, Hao, Z, Tian, Q, Zhang, Z, Zhou, C, Xie, W. 登録日 2013-05-15 公開日 2014-05-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.739 Å) 主引用文献 Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis J.Biol.Chem., 291, 2016

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