7NHI

Crystal structure of the human METTL3-METTL14 complex with compound UOZ004

Summary for 7NHI

Entry DOI	10.2210/pdb7nhi/pdb
Descriptor	N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl)piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl)methyl)benzamide, ... (5 entities in total)
Functional Keywords	mettl3, mettl14, m6a, inhibitor, complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	62290.99
Authors	Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-02-10, release date: 2021-09-01, Last modification date: 2024-02-07)
Primary citation	Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A. Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023 Cited by DOI: 10.1021/acsbiomedchemau.3c00023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation