7NOZ
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![BU of 7noz by Molmil](/molmil-images/mine/7noz) | Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 alpha chain, Complement C3 beta chain, ... | 著者 | Lorenzen, J, Pedersen, D.V, Andersen, G.R. | 登録日 | 2021-02-26 | 公開日 | 2022-07-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging. Protein Sci., 31, 2022
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5CIS
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![BU of 5cis by Molmil](/molmil-images/mine/5cis) | The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+ | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannan-binding lectin serine peptidase 2 | 著者 | Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J. | 登録日 | 2015-07-13 | 公開日 | 2017-01-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Structure, 25, 2017
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5CKM
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![BU of 5ckm by Molmil](/molmil-images/mine/5ckm) | The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+ | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannan-binding lectin serine peptidase 2 | 著者 | Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J. | 登録日 | 2015-07-15 | 公開日 | 2017-01-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Structure, 25, 2017
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7ATZ
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![BU of 7atz by Molmil](/molmil-images/mine/7atz) | |
6SOY
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![BU of 6soy by Molmil](/molmil-images/mine/6soy) | Trypanosoma brucei transferrin receptor in complex with human transferrin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, subunit of heterodimeric transferrin receptor, ... | 著者 | Trevor, C, Carrington, M, Higgins, M.K. | 登録日 | 2019-08-30 | 公開日 | 2019-11-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion. Nat Microbiol, 4, 2019
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6S9K
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![BU of 6s9k by Molmil](/molmil-images/mine/6s9k) | Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS | 分子名称: | 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, Caspase-2 | 著者 | Alblova, M, Obsil, T, Obsilova, V. | 登録日 | 2019-07-15 | 公開日 | 2020-01-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
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7NWD
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![BU of 7nwd by Molmil](/molmil-images/mine/7nwd) | Three-quartet c-kit2 G-quadruplex stabilized by a pyrene conjugate | 分子名称: | POTASSIUM ION, c-kit2_py1 | 著者 | Peterkova, K, Durnik, I, Marek, R, Plavec, J, Podbevsek, P. | 登録日 | 2021-03-16 | 公開日 | 2021-08-04 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | c-kit2 G-quadruplex stabilized via a covalent probe: exploring G-quartet asymmetry. Nucleic Acids Res., 49, 2021
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5OLM
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![BU of 5olm by Molmil](/molmil-images/mine/5olm) | TRIM21 | 分子名称: | E3 ubiquitin-protein ligase TRIM21, ZINC ION | 著者 | James, L.C. | 登録日 | 2017-07-28 | 公開日 | 2018-04-25 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. Elife, 7, 2018
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7OD0
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![BU of 7od0 by Molmil](/molmil-images/mine/7od0) | Mirolysin in complex with compound 9 | 分子名称: | 1,2-ETHANEDIOL, 2,1,3-benzothiadiazol-4-ylmethanamine, ACETATE ION, ... | 著者 | Zak, K.M, Bostock, M.J, Ksiazek, M. | 登録日 | 2021-04-28 | 公開日 | 2021-08-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia . J Enzyme Inhib Med Chem, 36, 2021
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6SJU
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![BU of 6sju by Molmil](/molmil-images/mine/6sju) | |
7AKV
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![BU of 7akv by Molmil](/molmil-images/mine/7akv) | The cryo-EM structure of the Vag8-C1 inhibitor complex | 分子名称: | Plasma protease C1 inhibitor, Vag8 | 著者 | Johnson, S, Lea, S.M, Deme, J.C, Furlong, E, Dhillon, A. | 登録日 | 2020-10-02 | 公開日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex. Mbio, 12, 2021
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6SHI
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![BU of 6shi by Molmil](/molmil-images/mine/6shi) | |
5ONQ
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![BU of 5onq by Molmil](/molmil-images/mine/5onq) | |
6SAD
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![BU of 6sad by Molmil](/molmil-images/mine/6sad) | |
7NXV
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![BU of 7nxv by Molmil](/molmil-images/mine/7nxv) | Crystal structure of the complex of DNase I/G-actin/PPP1R15A_582-621 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Yan, Y, Ron, D. | 登録日 | 2021-03-19 | 公開日 | 2021-09-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
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7NZM
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![BU of 7nzm by Molmil](/molmil-images/mine/7nzm) | Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Yan, Y, Hardwick, S, Ron, D. | 登録日 | 2021-03-24 | 公開日 | 2021-09-29 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
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5OX6
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![BU of 5ox6 by Molmil](/molmil-images/mine/5ox6) | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat | 分子名称: | Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Chowdhury, R, Zhang, D, Schofield, C.J. | 登録日 | 2017-09-06 | 公開日 | 2017-10-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
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5CKN
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![BU of 5ckn by Molmil](/molmil-images/mine/5ckn) | The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+ | 分子名称: | CALCIUM ION, Mannan-binding lectin serine peptidase 2 | 著者 | Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J. | 登録日 | 2015-07-15 | 公開日 | 2017-01-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Structure, 25, 2017
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7OFK
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![BU of 7ofk by Molmil](/molmil-images/mine/7ofk) | Ligand complex of RORg LBD | 分子名称: | (1~{R})-2-ethanoyl-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-5-methylsulfonyl-1,3-dihydroisoindole-1-carboxamide, DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, ... | 著者 | Xue, Y, Aagaard, A, Narjes, F. | 登録日 | 2021-05-05 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2. J.Med.Chem., 64, 2021
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7OFI
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![BU of 7ofi by Molmil](/molmil-images/mine/7ofi) | Ligand complex of RORg LBD | 分子名称: | (2~{R})-2-(4-ethylsulfonylphenyl)-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-~{N}'-methyl-butanediamide, DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, ... | 著者 | Xue, Y, Aagaard, A, Narjes, F. | 登録日 | 2021-05-05 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | 主引用文献 | AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2. J.Med.Chem., 64, 2021
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6SHH
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![BU of 6shh by Molmil](/molmil-images/mine/6shh) | |
6ZXK
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![BU of 6zxk by Molmil](/molmil-images/mine/6zxk) | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement | 分子名称: | Lethal factor, Protective antigen | 著者 | Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S. | 登録日 | 2020-07-29 | 公開日 | 2020-09-02 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state. Plos Pathog., 16, 2020
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7OIH
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![BU of 7oih by Molmil](/molmil-images/mine/7oih) | Glycosylation in the crystal structure of neutrophil myeloperoxidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Krawczyk, L, Semwal, S, Bouckaert, J. | 登録日 | 2021-05-11 | 公開日 | 2022-08-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | 主引用文献 | Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase. Acta Crystallogr D Struct Biol, 78, 2022
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4ZVL
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6ST3
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![BU of 6st3 by Molmil](/molmil-images/mine/6st3) | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide | 分子名称: | 4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide, Egl nine homolog 1, FORMIC ACID, ... | 著者 | Chowdhury, R, Holt-Martyn, J.P, Schofield, C.J. | 登録日 | 2019-09-10 | 公開日 | 2019-12-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.426 Å) | 主引用文献 | Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem, 15, 2020
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