PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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7NOZ	Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 alpha chain, Complement C3 beta chain, ... 著者 Lorenzen, J, Pedersen, D.V, Andersen, G.R. 登録日 2021-02-26 公開日 2022-07-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging. Protein Sci., 31, 2022
5CIS	The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+ 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannan-binding lectin serine peptidase 2 著者 Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J. 登録日 2015-07-13 公開日 2017-01-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Structure, 25, 2017
5CKM	The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+ 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannan-binding lectin serine peptidase 2 著者 Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J. 登録日 2015-07-15 公開日 2017-01-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Structure, 25, 2017
7ATZ	G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite 分子名称: DNA (5'-D(*GP*GP*TP*CP*TP*GP*AP*GP*GP*GP*AP*GP*AP*GP*GP*GP*GP*CP*TP*GP*GP*GP*T)-3') 著者 Vianney, Y.M, Weisz, K. 登録日 2020-11-02 公開日 2021-04-21 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 First Tandem Repeat of a Potassium Channel KCNN4 Minisatellite Folds into a V-Loop G-Quadruplex Structure. Biochemistry, 60, 2021
6SOY	Trypanosoma brucei transferrin receptor in complex with human transferrin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, subunit of heterodimeric transferrin receptor, ... 著者 Trevor, C, Carrington, M, Higgins, M.K. 登録日 2019-08-30 公開日 2019-11-06 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion. Nat Microbiol, 4, 2019
6S9K	Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS 分子名称: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, Caspase-2 著者 Alblova, M, Obsil, T, Obsilova, V. 登録日 2019-07-15 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
7NWD	Three-quartet c-kit2 G-quadruplex stabilized by a pyrene conjugate 分子名称: POTASSIUM ION, c-kit2_py1 著者 Peterkova, K, Durnik, I, Marek, R, Plavec, J, Podbevsek, P. 登録日 2021-03-16 公開日 2021-08-04 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 c-kit2 G-quadruplex stabilized via a covalent probe: exploring G-quartet asymmetry. Nucleic Acids Res., 49, 2021
5OLM	TRIM21 分子名称: E3 ubiquitin-protein ligase TRIM21, ZINC ION 著者 James, L.C. 登録日 2017-07-28 公開日 2018-04-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. Elife, 7, 2018
7OD0	Mirolysin in complex with compound 9 分子名称: 1,2-ETHANEDIOL, 2,1,3-benzothiadiazol-4-ylmethanamine, ACETATE ION, ... 著者 Zak, K.M, Bostock, M.J, Ksiazek, M. 登録日 2021-04-28 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia . J Enzyme Inhib Med Chem, 36, 2021
6SJU	Human kallikrein 7 with aromatic coumarinic ester compound 3 covalently bound to H57 分子名称: (3-iodanylphenyl) 6-methyl-2-oxidanylidene-chromene-3-carboxylate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Kallikrein-7, ... 著者 Hanke, S, Straeter, N. 登録日 2019-08-13 公開日 2020-05-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7. J.Med.Chem., 63, 2020
7AKV	The cryo-EM structure of the Vag8-C1 inhibitor complex 分子名称: Plasma protease C1 inhibitor, Vag8 著者 Johnson, S, Lea, S.M, Deme, J.C, Furlong, E, Dhillon, A. 登録日 2020-10-02 公開日 2021-06-16 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex. Mbio, 12, 2021
6SHI	Human kallikrein 7 with aromatic coumarinic ester compound 2 covalently bound to H57 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-methyl-2-oxidanylidene-chromene-3-carboxylic acid, Kallikrein-7, ... 著者 Hanke, S, Straeter, N. 登録日 2019-08-06 公開日 2020-05-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7. J.Med.Chem., 63, 2020
5ONQ	Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin 分子名称: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ... 著者 Leite, J.P, Gales, L. 登録日 2017-08-04 公開日 2018-08-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.17 Å) 主引用文献 Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product. FEBS Lett., 593, 2019
6SAD	Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164 分子名称: 14-3-3 protein gamma, Caspase-2 著者 Kalabova, D, Obsil, T, Obsilova, V. 登録日 2019-07-16 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.753 Å) 主引用文献 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
7NXV	Crystal structure of the complex of DNase I/G-actin/PPP1R15A_582-621 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yan, Y, Ron, D. 登録日 2021-03-19 公開日 2021-09-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
7NZM	Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yan, Y, Hardwick, S, Ron, D. 登録日 2021-03-24 公開日 2021-09-29 最終更新日 2021-10-20 実験手法 ELECTRON MICROSCOPY (3.96 Å) 主引用文献 Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
5OX6	HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat 分子名称: Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ... 著者 Chowdhury, R, Zhang, D, Schofield, C.J. 登録日 2017-09-06 公開日 2017-10-18 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
5CKN	The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+ 分子名称: CALCIUM ION, Mannan-binding lectin serine peptidase 2 著者 Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J. 登録日 2015-07-15 公開日 2017-01-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Structure, 25, 2017
7OFK	Ligand complex of RORg LBD 分子名称: (1~{R})-2-ethanoyl-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-5-methylsulfonyl-1,3-dihydroisoindole-1-carboxamide, DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, ... 著者 Xue, Y, Aagaard, A, Narjes, F. 登録日 2021-05-05 公開日 2022-03-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2. J.Med.Chem., 64, 2021
7OFI	Ligand complex of RORg LBD 分子名称: (2~{R})-2-(4-ethylsulfonylphenyl)-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-~{N}'-methyl-butanediamide, DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, ... 著者 Xue, Y, Aagaard, A, Narjes, F. 登録日 2021-05-05 公開日 2022-03-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.953 Å) 主引用文献 AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2. J.Med.Chem., 64, 2021
6SHH	Human kallikrein 7 with aromatic coumarinic ester compound 1 covalently bound to H57 分子名称: (3-chlorophenyl) 6-methyl-2-oxidanylidene-chromene-3-carboxylate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Kallikrein-7, ... 著者 Hanke, S, Straeter, N. 登録日 2019-08-06 公開日 2020-05-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7. J.Med.Chem., 63, 2020
6ZXK	Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement 分子名称: Lethal factor, Protective antigen 著者 Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S. 登録日 2020-07-29 公開日 2020-09-02 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state. Plos Pathog., 16, 2020
7OIH	Glycosylation in the crystal structure of neutrophil myeloperoxidase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Krawczyk, L, Semwal, S, Bouckaert, J. 登録日 2021-05-11 公開日 2022-08-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.603 Å) 主引用文献 Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase. Acta Crystallogr D Struct Biol, 78, 2022
4ZVL	Oxidized quinone reductase 2 in complex with acridine orange 分子名称: ACRIDINE ORANGE, FLAVIN-ADENINE DINUCLEOTIDE, Ribosyldihydronicotinamide dehydrogenase [quinone], ... 著者 Leung, K.K, Shilton, B.H. 登録日 2015-05-18 公開日 2016-04-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.899 Å) 主引用文献 Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2. Biochemistry, 54, 2015
6ST3	HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide 分子名称: 4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide, Egl nine homolog 1, FORMIC ACID, ... 著者 Chowdhury, R, Holt-Martyn, J.P, Schofield, C.J. 登録日 2019-09-10 公開日 2019-12-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.426 Å) 主引用文献 Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem, 15, 2020

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