5OX6

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat

Summary for 5OX6

DescriptorEgl nine homolog 1, MANGANESE (II) ION, Vadadustat, ... (6 entities in total)
Functional Keywordsoxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  Q9GZT9
Total number of polymer chains1
Total molecular weight28834.89
Authors
Chowdhury, R.,Zhang, D.,Schofield, C.J. (deposition date: 2017-09-06, release date: 2017-10-18, Last modification date: 2018-02-21)
Primary citation
Yeh, T.L.,Leissing, T.M.,Abboud, M.I.,Thinnes, C.C.,Atasoylu, O.,Holt-Martyn, J.P.,Zhang, D.,Tumber, A.,Lippl, K.,Lohans, C.T.,Leung, I.K.H.,Morcrette, H.,Clifton, I.J.,Claridge, T.D.W.,Kawamura, A.,Flashman, E.,Lu, X.,Ratcliffe, P.J.,Chowdhury, R.,Pugh, C.W.,Schofield, C.J.
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Chem Sci, 8:7651-7668, 2017
PubMed: 29435217 (PDB entries with the same primary citation)
DOI: 10.1039/c7sc02103h
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.99 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20520 0.6% 5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25