6SHH
Human kallikrein 7 with aromatic coumarinic ester compound 1 covalently bound to H57
Summary for 6SHH
Entry DOI | 10.2210/pdb6shh/pdb |
Descriptor | Kallikrein-7, TRIETHYLENE GLYCOL, SULFATE ION, ... (6 entities in total) |
Functional Keywords | serine protease, covalent inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 207417.57 |
Authors | Hanke, S.,Straeter, N. (deposition date: 2019-08-06, release date: 2020-05-20, Last modification date: 2024-01-24) |
Primary citation | Hanke, S.,Tindall, C.A.,Pippel, J.,Ulbricht, D.,Pirotte, B.,Reboud-Ravaux, M.,Heiker, J.T.,Strater, N. Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7. J.Med.Chem., 63:5723-5733, 2020 Cited by PubMed: 32374603DOI: 10.1021/acs.jmedchem.9b01806 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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