Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6SHH

Human kallikrein 7 with aromatic coumarinic ester compound 1 covalently bound to H57

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001533	cellular_component	cornified envelope
A	0002780	biological_process	antibacterial peptide biosynthetic process
A	0004222	molecular_function	metalloendopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008544	biological_process	epidermis development
A	0016787	molecular_function	hydrolase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0030141	cellular_component	secretory granule
A	0051604	biological_process	protein maturation
A	0097209	cellular_component	epidermal lamellar body
B	0001533	cellular_component	cornified envelope
B	0002780	biological_process	antibacterial peptide biosynthetic process
B	0004222	molecular_function	metalloendopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0008544	biological_process	epidermis development
B	0016787	molecular_function	hydrolase activity
B	0022617	biological_process	extracellular matrix disassembly
B	0030141	cellular_component	secretory granule
B	0051604	biological_process	protein maturation
B	0097209	cellular_component	epidermal lamellar body
C	0001533	cellular_component	cornified envelope
C	0002780	biological_process	antibacterial peptide biosynthetic process
C	0004222	molecular_function	metalloendopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0008544	biological_process	epidermis development
C	0016787	molecular_function	hydrolase activity
C	0022617	biological_process	extracellular matrix disassembly
C	0030141	cellular_component	secretory granule
C	0051604	biological_process	protein maturation
C	0097209	cellular_component	epidermal lamellar body
D	0001533	cellular_component	cornified envelope
D	0002780	biological_process	antibacterial peptide biosynthetic process
D	0004222	molecular_function	metalloendopeptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008544	biological_process	epidermis development
D	0016787	molecular_function	hydrolase activity
D	0022617	biological_process	extracellular matrix disassembly
D	0030141	cellular_component	secretory granule
D	0051604	biological_process	protein maturation
D	0097209	cellular_component	epidermal lamellar body
E	0001533	cellular_component	cornified envelope
E	0002780	biological_process	antibacterial peptide biosynthetic process
E	0004222	molecular_function	metalloendopeptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005886	cellular_component	plasma membrane
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0008544	biological_process	epidermis development
E	0016787	molecular_function	hydrolase activity
E	0022617	biological_process	extracellular matrix disassembly
E	0030141	cellular_component	secretory granule
E	0051604	biological_process	protein maturation
E	0097209	cellular_component	epidermal lamellar body
F	0001533	cellular_component	cornified envelope
F	0002780	biological_process	antibacterial peptide biosynthetic process
F	0004222	molecular_function	metalloendopeptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005886	cellular_component	plasma membrane
F	0006508	biological_process	proteolysis
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0008544	biological_process	epidermis development
F	0016787	molecular_function	hydrolase activity
F	0022617	biological_process	extracellular matrix disassembly
F	0030141	cellular_component	secretory granule
F	0051604	biological_process	protein maturation
F	0097209	cellular_component	epidermal lamellar body
G	0001533	cellular_component	cornified envelope
G	0002780	biological_process	antibacterial peptide biosynthetic process
G	0004222	molecular_function	metalloendopeptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005886	cellular_component	plasma membrane
G	0006508	biological_process	proteolysis
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0008544	biological_process	epidermis development
G	0016787	molecular_function	hydrolase activity
G	0022617	biological_process	extracellular matrix disassembly
G	0030141	cellular_component	secretory granule
G	0051604	biological_process	protein maturation
G	0097209	cellular_component	epidermal lamellar body
H	0001533	cellular_component	cornified envelope
H	0002780	biological_process	antibacterial peptide biosynthetic process
H	0004222	molecular_function	metalloendopeptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005886	cellular_component	plasma membrane
H	0006508	biological_process	proteolysis
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0008544	biological_process	epidermis development
H	0016787	molecular_function	hydrolase activity
H	0022617	biological_process	extracellular matrix disassembly
H	0030141	cellular_component	secretory granule
H	0051604	biological_process	protein maturation
H	0097209	cellular_component	epidermal lamellar body

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PGE A 301

Chain	Residue
A	LEU34
A	ASN38
A	GLY76
A	ARG82
A	HOH436
A	HOH463
C	SO4304

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 302

Chain	Residue
A	SO4305
A	HOH420
D	LYS236
A	LYS59
A	ARG90

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 303

Chain	Residue
A	MET60
A	ASN61
A	GLU63
A	HOH425
A	HOH439
B	ARG90

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 304

Chain	Residue
A	SER125
A	ARG128
H	ARG82

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS59
A	SER86
A	SER88
A	SO4302
A	HOH414
A	HOH418

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 306

Chain	Residue
A	ALA23
A	ARG24
A	HOH429

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 A 307

Chain	Residue
A	PRO165
A	LYS233
A	HOH401
A	HOH407
A	HOH470
H	EPE301

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 A 308

Chain	Residue
A	VAL158
A	ASP159
A	LYS188
A	HOH452
A	HOH469

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 A 309

Chain	Residue
A	ARG50
A	ASN109
A	SER110
A	GLN111

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 A 310

Chain	Residue
A	TRP29
A	VAL121
A	ARG122
A	VAL200
A	GLY207

site_id	AD2
Number of Residues	15
Details	binding site for residue SH7 A 350

Chain	Residue
A	LEU40
A	HIS41
A	HIS57
A	HIS99
A	ASN192
A	GLY193
A	SER195
A	TRP215
A	GLY216
A	HOH438
B	HIS57
B	THR96
B	GLN97
B	ASN192
B	HOH425

site_id	AD3
Number of Residues	7
Details	binding site for residue SO4 B 301

Chain	Residue
B	LYS59
B	SER88
B	ARG90
B	SO4305
B	HOH443
B	HOH472
C	LYS236

site_id	AD4
Number of Residues	9
Details	binding site for residue SO4 B 302

Chain	Residue
A	GLN81
A	ARG82
A	ARG113
A	HOH456
B	ALA23
B	ARG24
B	HOH428
C	ARG128
C	SO4306

site_id	AD5
Number of Residues	7
Details	binding site for residue SO4 B 303

Chain	Residue
A	ARG90
B	MET60
B	ASN61
B	GLU63
B	HOH435
B	HOH468
D	HOH469

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 B 304

Chain	Residue
B	SER125
B	ARG128
C	ALA23
C	HOH457
E	ARG82

site_id	AD7
Number of Residues	6
Details	binding site for residue SO4 B 305

Chain	Residue
B	LYS59
B	SER86
B	SER88
B	SO4301
B	HOH420
B	HOH472

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 B 306

Chain	Residue
B	GLY36
B	HOH480
D	LYS236

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 B 307

Chain	Residue
B	ALA80
B	GLN81
B	ARG82
D	ARG128

site_id	AE1
Number of Residues	5
Details	binding site for residue SO4 B 308

Chain	Residue
B	LYS84
B	ASN109
B	SER110
B	HOH427
B	HOH479

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 B 309

Chain	Residue
B	ARG50
B	SER110
B	GLN111
B	HOH436

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 B 310

Chain	Residue
A	SER115
A	SER116
B	HOH409
B	HOH442
B	HOH462

site_id	AE4
Number of Residues	2
Details	binding site for residue SO4 B 311

Chain	Residue
B	ARG50
B	HOH436

site_id	AE5
Number of Residues	5
Details	binding site for residue SO4 B 312

Chain	Residue
B	ASN178
B	LYS233
B	HOH430
B	HOH446
E	PGE301

site_id	AE6
Number of Residues	5
Details	binding site for residue SO4 B 313

Chain	Residue
A	ILE83
A	LYS84
A	ASN109
A	SER110
B	ARG24

site_id	AE7
Number of Residues	6
Details	binding site for residue SO4 C 301

Chain	Residue
B	LYS236
C	LYS59
C	SER88
C	ARG90
C	SO4308
C	HOH450

site_id	AE8
Number of Residues	9
Details	binding site for residue SO4 C 302

Chain	Residue
B	ARG128
C	ALA23
C	ARG24
C	HOH408
C	HOH457
E	GLN81
E	ARG82
E	ARG113
E	HOH423

site_id	AE9
Number of Residues	5
Details	binding site for residue SO4 C 303

Chain	Residue
C	MET60
C	ASN61
C	GLU63
E	ARG90
E	HOH481

site_id	AF1
Number of Residues	7
Details	binding site for residue SO4 C 304

Chain	Residue
A	PGE301
C	ASN178
C	GLN230
C	LYS233
C	HOH418
C	HOH464
C	HOH469

site_id	AF2
Number of Residues	3
Details	binding site for residue SO4 C 305

Chain	Residue
C	ARG50
C	SER110
C	GLN111

site_id	AF3
Number of Residues	5
Details	binding site for residue SO4 C 306

Chain	Residue
A	ARG82
B	ALA23
B	SO4302
C	SER125
C	ARG128

site_id	AF4
Number of Residues	2
Details	binding site for residue SO4 C 307

Chain	Residue
C	GLN81
C	HOH430

site_id	AF5
Number of Residues	7
Details	binding site for residue SO4 C 308

Chain	Residue
C	LYS59
C	SER86
C	LYS87
C	SER88
C	SO4301
C	HOH417
C	HOH462

site_id	AF6
Number of Residues	5
Details	binding site for residue SO4 C 309

Chain	Residue
C	HOH402
C	HOH425
C	HOH439
F	SER115
F	SER116

site_id	AF7
Number of Residues	7
Details	binding site for residue SO4 C 310

Chain	Residue
B	VAL200
B	ARG202
B	GLY207
B	HOH417
C	ARG202
C	SO4311
C	HOH427

site_id	AF8
Number of Residues	7
Details	binding site for residue SO4 C 311

Chain	Residue
B	ARG202
C	ARG202
C	GLY207
C	SO4310
C	HOH403
C	HOH415
C	HOH472

site_id	AF9
Number of Residues	3
Details	binding site for residue SO4 C 312

Chain	Residue
C	SER186
C	LYS188
C	HOH490

site_id	AG1
Number of Residues	5
Details	binding site for residue SO4 C 313

Chain	Residue
C	ARG24
E	ILE83
E	LYS84
E	ASN109
E	SER110

site_id	AG2
Number of Residues	9
Details	binding site for residue PGE D 301

Chain	Residue
D	ASN38
D	LEU73
D	GLY76
D	ARG82
D	SER153
D	HOH527
F	ARG128
F	CYS129
F	SO4307

site_id	AG3
Number of Residues	6
Details	binding site for residue SO4 D 302

Chain	Residue
A	LYS236
D	LYS59
D	PHE89
D	ARG90
D	SO4306
D	HOH472

site_id	AG4
Number of Residues	4
Details	binding site for residue SO4 D 303

Chain	Residue
D	SER125
D	ARG128
D	HOH434
D	HOH461

site_id	AG5
Number of Residues	4
Details	binding site for residue SO4 D 304

Chain	Residue
D	MET60
D	ASN61
D	GLU63
H	ARG90

site_id	AG6
Number of Residues	2
Details	binding site for residue SO4 D 305

Chain	Residue
D	ARG24
D	HOH420

site_id	AG7
Number of Residues	8
Details	binding site for residue SO4 D 306

Chain	Residue
D	LYS59
D	SER86
D	LYS87
D	SER88
D	SO4302
D	HOH416
D	HOH438
D	HOH471

site_id	AG8
Number of Residues	3
Details	binding site for residue SO4 D 307

Chain	Residue
D	ARG50
D	SER110
D	GLN111

site_id	AG9
Number of Residues	4
Details	binding site for residue SO4 D 308

Chain	Residue
D	ASN178
D	GLN230
D	LYS233
D	HOH447

site_id	AH1
Number of Residues	4
Details	binding site for residue SO4 D 309

Chain	Residue
D	VAL158
D	ASP159
D	LYS188
D	HOH432

site_id	AH2
Number of Residues	3
Details	binding site for residue SO4 D 310

Chain	Residue
D	ARG50
D	GLN111
D	HOH417

site_id	AH3
Number of Residues	2
Details	binding site for residue SO4 D 311

Chain	Residue
D	SER35
D	GLY36

site_id	AH4
Number of Residues	9
Details	binding site for residue PGE E 301

Chain	Residue
B	CYS129
B	SO4312
E	ASN38
E	LEU73
E	GLY76
E	ARG82
E	PHE151
E	HOH410
E	HOH430

site_id	AH5
Number of Residues	4
Details	binding site for residue SO4 E 302

Chain	Residue
E	LYS59
E	SER88
E	ARG90
E	SO4304

site_id	AH6
Number of Residues	7
Details	binding site for residue SO4 E 303

Chain	Residue
C	ARG90
E	MET60
E	ASN61
E	GLU63
E	HOH421
E	HOH448
E	HOH482

site_id	AH7
Number of Residues	8
Details	binding site for residue SO4 E 304

Chain	Residue
E	LYS59
E	SER86
E	LYS87
E	SER88
E	SO4302
E	HOH411
E	HOH464
E	HOH505

site_id	AH8
Number of Residues	3
Details	binding site for residue SO4 E 305

Chain	Residue
E	SER125
E	ARG128
F	ARG82

site_id	AH9
Number of Residues	2
Details	binding site for residue SO4 E 306

Chain	Residue
B	LYS236
E	GLY36

site_id	AI1
Number of Residues	4
Details	binding site for residue SO4 E 307

Chain	Residue
E	ASN109
E	SER110
E	GLN111
E	SO4308

site_id	AI2
Number of Residues	7
Details	binding site for residue SO4 E 308

Chain	Residue
E	ARG50
E	LEU108
E	ASN109
E	SER110
E	GLN111
E	SO4307
E	HOH499

site_id	AI3
Number of Residues	7
Details	binding site for residue SO4 E 309

Chain	Residue
E	SER164
E	PRO165
E	GLN166
E	HOH432
E	HOH445
F	PRO152
F	SER153

site_id	AI4
Number of Residues	11
Details	binding site for residue PGE F 301

Chain	Residue
D	GLN39
F	HIS91
F	LYS233
F	PHE234
F	LYS236
F	TRP237
F	HOH412
F	HOH448
F	HOH462
H	PRO92
H	SER95

site_id	AI5
Number of Residues	6
Details	binding site for residue SO4 F 302

Chain	Residue
F	LYS59
F	ARG90
F	SO4308
F	HOH433
F	HOH475
H	LYS236

site_id	AI6
Number of Residues	4
Details	binding site for residue SO4 F 303

Chain	Residue
F	ASN61
F	GLU63
F	HOH469
G	ARG90

site_id	AI7
Number of Residues	5
Details	binding site for residue SO4 F 304

Chain	Residue
B	LYS170
D	ARG78
F	THR134
F	THR135
F	ARG202

site_id	AI8
Number of Residues	5
Details	binding site for residue SO4 F 305

Chain	Residue
F	ARG50
F	ASN109
F	SER110
F	GLN111
F	HOH434

site_id	AI9
Number of Residues	4
Details	binding site for residue SO4 F 306

Chain	Residue
F	ARG90
G	MET60
G	ASN61
G	GLU63

site_id	AJ1
Number of Residues	5
Details	binding site for residue SO4 F 307

Chain	Residue
D	PGE301
F	ASN178
F	LYS233
F	HOH446
F	HOH463

site_id	AJ2
Number of Residues	5
Details	binding site for residue SO4 F 308

Chain	Residue
F	LYS59
F	SER88
F	SO4302
F	HOH411
F	HOH433

site_id	AJ3
Number of Residues	4
Details	binding site for residue SO4 F 309

Chain	Residue
F	ARG50
F	GLN111
F	HOH426
F	HOH487

site_id	AJ4
Number of Residues	3
Details	binding site for residue SO4 F 310

Chain	Residue
E	GLN230
E	LYS233
F	HOH408

site_id	AJ5
Number of Residues	3
Details	binding site for residue SO4 F 311

Chain	Residue
D	ARG82
F	SER125
F	ARG128

site_id	AJ6
Number of Residues	9
Details	binding site for residue EPE G 301

Chain	Residue
G	ASN38
G	LEU73
G	GLY76
G	ARG82
G	PHE151
G	HOH446
H	ARG128
H	CYS129
H	SO4304

site_id	AJ7
Number of Residues	7
Details	binding site for residue SO4 G 302

Chain	Residue
F	HOH469
G	LYS59
G	SER88
G	PHE89
G	ARG90
G	SO4303
G	HOH401

site_id	AJ8
Number of Residues	5
Details	binding site for residue SO4 G 303

Chain	Residue
G	LYS59
G	LYS87
G	SER88
G	SO4302
G	HOH405

site_id	AJ9
Number of Residues	3
Details	binding site for residue SO4 G 304

Chain	Residue
G	ARG50
G	SER110
G	GLN111

site_id	AK1
Number of Residues	5
Details	binding site for residue SO4 G 305

Chain	Residue
C	PRO152
C	SER153
G	PRO165
G	GLN166
G	HOH443

site_id	AK2
Number of Residues	3
Details	binding site for residue SO4 G 306

Chain	Residue
G	VAL158
G	ASP159
G	LYS188

site_id	AK3
Number of Residues	5
Details	binding site for residue SO4 G 307

Chain	Residue
G	ASP18
G	SER186
G	LYS188
G	HOH416
G	HOH462

site_id	AK4
Number of Residues	3
Details	binding site for residue SO4 G 308

Chain	Residue
G	ARG50
G	GLN111
G	ARG246

site_id	AK5
Number of Residues	3
Details	binding site for residue SO4 G 309

Chain	Residue
C	ARG82
G	SER125
G	ARG128

site_id	AK6
Number of Residues	5
Details	binding site for residue SO4 G 310

Chain	Residue
G	ALA80
G	GLN81
G	ARG82
G	ARG113
H	ARG128

site_id	AK7
Number of Residues	9
Details	binding site for residue EPE H 301

Chain	Residue
A	CYS129
A	SO4307
H	ASN38
H	LEU73
H	ARG82
H	PHE151
H	HOH401
H	HOH412
H	HOH432

site_id	AK8
Number of Residues	7
Details	binding site for residue SO4 H 302

Chain	Residue
F	LYS236
H	LYS59
H	PHE89
H	ARG90
H	SO4305
H	HOH421
H	HOH453

site_id	AK9
Number of Residues	5
Details	binding site for residue SO4 H 303

Chain	Residue
D	ARG90
H	MET60
H	ASN61
H	GLU63
H	HOH410

site_id	AL1
Number of Residues	5
Details	binding site for residue SO4 H 304

Chain	Residue
G	GLN39
G	EPE301
H	ASN178
H	LYS233
H	HOH417

site_id	AL2
Number of Residues	7
Details	binding site for residue SO4 H 305

Chain	Residue
H	LYS59
H	SER86
H	LYS87
H	SER88
H	SO4302
H	HOH421
H	HOH422

site_id	AL3
Number of Residues	4
Details	binding site for residue SO4 H 306

Chain	Residue
A	LYS236
H	GLY36
H	HOH410
H	HOH459

site_id	AL4
Number of Residues	3
Details	binding site for residue SO4 H 307

Chain	Residue
H	VAL158
H	ASP159
H	LYS188

site_id	AL5
Number of Residues	3
Details	binding site for residue SO4 H 308

Chain	Residue
H	ARG50
H	SER110
H	GLN111

site_id	AL6
Number of Residues	6
Details	binding site for residue SO4 H 309

Chain	Residue
H	ILE83
H	LYS84
H	ASN109
H	SER110
H	HOH415
H	HOH431

site_id	AL7
Number of Residues	2
Details	binding site for residue SO4 H 310

Chain	Residue
G	ARG82
H	ARG128

site_id	AL8
Number of Residues	3
Details	binding site for residue SO4 H 311

Chain	Residue
H	GLY133
H	THR134
H	THR135

site_id	AL9
Number of Residues	4
Details	binding site for residue SO4 H 312

Chain	Residue
H	ALA80
H	GLN81
H	ARG82
H	ARG113

site_id	AM1
Number of Residues	20
Details	binding site for Di-peptide SH7 B 314 and HIS B 57

Chain	Residue
A	THR96
A	GLN97
A	ASN192
A	PHE218
A	SH7350
B	LEU40
B	HIS41
B	ALA55
B	ALA56
B	CYS58
B	LYS59
B	TYR94
B	HIS99
B	ASP102
B	ASN192
B	GLY193
B	TRP215
B	GLY216
B	HOH418
B	HOH470

site_id	AM2
Number of Residues	22
Details	binding site for Di-peptide SH7 C 314 and HIS C 57

Chain	Residue
C	LEU40
C	HIS41
C	ALA55
C	ALA56
C	CYS58
C	LYS59
C	TYR94
C	HIS99
C	ASP102
C	ASN192
C	GLY193
C	SER195
C	TRP215
C	GLY216
C	HOH411
C	HOH466
C	HOH478
C	HOH535
C	HOH556
E	THR96
E	GLN97
E	PHE218

site_id	AM3
Number of Residues	23
Details	binding site for Di-peptide SH7 D 312 and HIS D 57

Chain	Residue
D	LEU40
D	HIS41
D	ALA55
D	ALA56
D	CYS58
D	LYS59
D	TYR94
D	HIS99
D	ASP102
D	PHE151
D	ASN192
D	GLY193
D	SER195
D	TRP215
D	GLY216
D	HOH415
D	HOH510
H	HIS57
H	THR96
H	GLN97
H	ASN192
H	PHE218
H	SH7350

site_id	AM4
Number of Residues	20
Details	binding site for Di-peptide SH7 E 310 and HIS E 57

Chain	Residue
C	THR96
C	GLN97
C	PHE218
E	LEU40
E	HIS41
E	ALA55
E	ALA56
E	CYS58
E	LYS59
E	TYR94
E	HIS99
E	ASP102
E	ASN192
E	GLY193
E	SER195
E	TRP215
E	GLY216
E	HOH414
E	HOH417
E	HOH506

site_id	AM5
Number of Residues	22
Details	binding site for Di-peptide SH7 F 312 and HIS F 57

Chain	Residue
F	LEU40
F	HIS41
F	ALA55
F	ALA56
F	CYS58
F	LYS59
F	TYR94
F	HIS99
F	ASP102
F	ASN192
F	GLY193
F	SER195
F	TRP215
F	GLY216
F	HOH419
F	HOH456
F	HOH567
G	HIS57
G	THR96
G	GLN97
G	SH7350
G	HOH442

site_id	AM6
Number of Residues	22
Details	binding site for Di-peptide SH7 G 311 and HIS G 57

Chain	Residue
F	HIS57
F	THR96
F	GLN97
F	PHE218
F	SH7350
G	LEU40
G	HIS41
G	CYS42
G	ALA55
G	ALA56
G	CYS58
G	LYS59
G	TYR94
G	ASP102
G	PHE151
G	ASN192
G	GLY193
G	SER195
G	TRP215
G	GLY216
G	HOH457
G	HOH483

site_id	AM7
Number of Residues	24
Details	binding site for Di-peptide SH7 H 313 and HIS H 57

Chain	Residue
D	HIS57
D	THR96
D	GLN97
D	PHE218
D	SH7350
D	HOH409
H	LEU40
H	HIS41
H	ALA55
H	ALA56
H	CYS58
H	LYS59
H	TYR94
H	HIS99
H	ASP102
H	PHE151
H	ASN192
H	GLY193
H	SER195
H	GLY216
H	HOH419
H	HOH438
H	HOH458
H	HOH492

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. NAcnGDSGGPLV

Chain	Residue	Details
A	ASN189-VAL200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1760
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"17909180","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Site: {"description":"Major binding site for inhibitory zinc or copper"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)