6SHI

Human kallikrein 7 with aromatic coumarinic ester compound 2 covalently bound to H57

Summary for 6SHI

Entry DOI	10.2210/pdb6shi/pdb
Descriptor	Kallikrein-7, TRIETHYLENE GLYCOL, 6-methyl-2-oxidanylidene-chromene-3-carboxylic acid, ... (6 entities in total)
Functional Keywords	serine protease, covalent inhibitor, complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	206917.49
Authors	Hanke, S.,Straeter, N. (deposition date: 2019-08-06, release date: 2020-05-20, Last modification date: 2024-01-24)
Primary citation	Hanke, S.,Tindall, C.A.,Pippel, J.,Ulbricht, D.,Pirotte, B.,Reboud-Ravaux, M.,Heiker, J.T.,Strater, N. Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7. J.Med.Chem., 63:5723-5733, 2020 Cited by PubMed: 32374603 DOI: 10.1021/acs.jmedchem.9b01806 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation