7U2U
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![BU of 7u2u by Molmil](/molmil-images/mine/7u2u) | CRYSTAL STRUCTURE OF HIV-1 INTEGRASE COMPLEXED WITH Compound-2a AKA (2S)-2-(TERT-BUTOXY)-2-[7-(4,4-DIMETHYLPIPE RIDIN-1-YL)-8-{4-[2-(4-FLUOROPHENYL)ETHOXY]PHENYL}-2,5-DIM ETHYLIMIDAZO[1,2-A]PYRIDIN-6-YL]ACETIC ACID | 分子名称: | (2S)-tert-butoxy[(4S)-7-(4,4-dimethylpiperidin-1-yl)-8-{4-[2-(4-fluorophenyl)ethoxy]phenyl}-2,5-dimethylimidazo[1,2-a]pyridin-6-yl]acetic acid, Integrase, SULFATE ION | 著者 | Khan, J.A, lewis, H, Kish, K. | 登録日 | 2022-02-24 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.839 Å) | 主引用文献 | Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors. Bioorg.Med.Chem., 67, 2022
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7Z1Z
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![BU of 7z1z by Molmil](/molmil-images/mine/7z1z) | MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution | 分子名称: | DNA (37-MER), DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*TP*AP*GP*GP*GP*TP*G)-3'), ... | 著者 | Pye, V.E, Ballandras-Colas, A, Cherepanov, P. | 登録日 | 2022-02-25 | 公開日 | 2022-05-11 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Multivalent interactions essential for lentiviral integrase function. Nat Commun, 13, 2022
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7U32
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![BU of 7u32 by Molmil](/molmil-images/mine/7u32) | MVV cleaved synaptic complex (CSC) intasome at 3.4 A resolution | 分子名称: | CALCIUM ION, DNA EV272, DNA EV273, ... | 著者 | Shan, Z, Pye, V.E, Cherepanov, P, Lyumkis, D. | 登録日 | 2022-02-25 | 公開日 | 2022-05-11 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Multivalent interactions essential for lentiviral integrase function. Nat Commun, 13, 2022
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7Z2Z
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![BU of 7z2z by Molmil](/molmil-images/mine/7z2z) | Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A | 分子名称: | (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | 著者 | Nguyen, P.Q, Fernandez-Tornero, C. | 登録日 | 2022-03-01 | 公開日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nat Commun, 14, 2023
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7Z31
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![BU of 7z31 by Molmil](/molmil-images/mine/7z31) | Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.7 A (focus subunit C11, no C11 C-terminal Zn-ribbon in the funnel pore). | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | 著者 | Nguyen, P.Q, Huecas, S, Plaza-Pegueroles, A, Fernandez-Tornero, C. | 登録日 | 2022-03-01 | 公開日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nat Commun, 14, 2023
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7Z30
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![BU of 7z30 by Molmil](/molmil-images/mine/7z30) | |
7UE1
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![BU of 7ue1 by Molmil](/molmil-images/mine/7ue1) | HIV-1 Integrase Catalytic Core Domain Mutant (KGD) in Complex with Inhibitor GRL-142 | 分子名称: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, Integrase, SULFATE ION | 著者 | Aoki, M, Aoki-Ogata, H, Bulut, H, Hayashi, H, Davis, D, Hasegawa, K, Yarchoan, R, Ghosh, A.K, Pau, A.K, Mitsuya, H. | 登録日 | 2022-03-21 | 公開日 | 2023-03-22 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants. Sci Adv, 9, 2023
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7UOQ
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![BU of 7uoq by Molmil](/molmil-images/mine/7uoq) | CRYSTAL STRUCTURE OF HIV-1 INTEGRASE COMPLEXED WITH (2S)-2-(TERT-BUTOXY)-2-(5-{2-[(2-CHLORO-6-M ETHYLPHENYL)METHYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL}-4- (4,4-DIMETHYLPIPERIDIN-1-YL)-2-METHYLPYRIDIN-3-YL)ACETIC ACID | 分子名称: | (2S)-tert-butoxy[(5M)-5-{2-[(2-chloro-6-methylphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-6-yl}-4-(4,4-dimethylpiperidin-1-yl)-2-methylpyridin-3-yl]acetic acid, Integrase, SULFATE ION | 著者 | Lewis, H.A, Muckelbauer, J.K. | 登録日 | 2022-04-13 | 公開日 | 2022-07-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8867 Å) | 主引用文献 | Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7USF
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![BU of 7usf by Molmil](/molmil-images/mine/7usf) | |
7UT1
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![BU of 7ut1 by Molmil](/molmil-images/mine/7ut1) | |
7ZPP
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![BU of 7zpp by Molmil](/molmil-images/mine/7zpp) | Cryo-EM structure of the MVV CSC intasome at 4.5A resolution | 分子名称: | Integrase, vDNA, non-transferred strand, ... | 著者 | Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2022-04-28 | 公開日 | 2022-05-11 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration Science, 355, 2017
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8CT7
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![BU of 8ct7 by Molmil](/molmil-images/mine/8ct7) | Catalytic Core Domain of HIV-1 Integrase (F185K) bound with BI-224436 | 分子名称: | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, Integrase, ... | 著者 | Gupta, K, Van Duyne, G.D, Eilers, G, Bushman, F.D. | 登録日 | 2022-05-13 | 公開日 | 2023-02-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization. Plos Pathog., 19, 2023
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8CT5
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![BU of 8ct5 by Molmil](/molmil-images/mine/8ct5) | |
8CTA
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![BU of 8cta by Molmil](/molmil-images/mine/8cta) | Minimal 2:2 Ternary Complex between BI-224436 bound HIV-1 Integrase Catalytic Core Domain Dimer and Carboxy Terminal Domains | 分子名称: | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, Integrase | 著者 | Gupta, K, Van Duyne, G.D, Eilers, G, Bushman, F.D. | 登録日 | 2022-05-13 | 公開日 | 2023-02-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization. Plos Pathog., 19, 2023
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8A1Q
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![BU of 8a1q by Molmil](/molmil-images/mine/8a1q) | HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor STP0404 (Pirmitegravir) | 分子名称: | (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, 1,2-ETHANEDIOL, Integrase, ... | 著者 | Singer, M.R, Pye, V.E, Cook, N.J, Cherepanov, P. | 登録日 | 2022-06-01 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. Mbio, 14, 2023
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8A1P
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![BU of 8a1p by Molmil](/molmil-images/mine/8a1p) | HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D | 分子名称: | (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Singer, M.R, Pye, V.E, Cook, N.J, Cherepanov, P. | 登録日 | 2022-06-01 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. Mbio, 14, 2023
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8D3S
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![BU of 8d3s by Molmil](/molmil-images/mine/8d3s) | |
8E14
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![BU of 8e14 by Molmil](/molmil-images/mine/8e14) | Cryo-EM structure of Rous sarcoma virus strand transfer complex | 分子名称: | DNA (42-MER), DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*TP*AP*CP*TP*C)-3'), DNA (5'-D(*AP*GP*TP*GP*TP*CP*TP*TP*CP*TP*TP*CP*TP*TP*TP*C)-3'), ... | 著者 | Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P. | 登録日 | 2022-08-09 | 公開日 | 2023-04-26 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Molecular determinants for Rous sarcoma virus intasome assemblies involved in retroviral integration. J.Biol.Chem., 299, 2023
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8B4H
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![BU of 8b4h by Molmil](/molmil-images/mine/8b4h) | IstA transposase cleaved donor complex | 分子名称: | DNA (55-MER) / right IS21 transposon end (insertion sequence IS5376), DNA (57-MER) / right IS21 transposon end (insertion sequence IS5376), MAGNESIUM ION, ... | 著者 | Spinola-Amilibia, M, de la Gandara, A, Araujo-Bazan, L, Berger, J.M, Arias-Palomo, E. | 登録日 | 2022-09-20 | 公開日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | IS21 family transposase cleaved donor complex traps two right-handed superhelical crossings. Nat Commun, 14, 2023
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8BUV
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![BU of 8buv by Molmil](/molmil-images/mine/8buv) | HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor LEDGIN 3 | 分子名称: | (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, 1,2-ETHANEDIOL, Integrase, ... | 著者 | Singer, M.R, Pye, V.E, Cook, N.J, Cherepanov, P. | 登録日 | 2022-11-30 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor LEDGIN 3 To Be Published
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8BV2
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![BU of 8bv2 by Molmil](/molmil-images/mine/8bv2) | |
8FNM
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![BU of 8fnm by Molmil](/molmil-images/mine/8fnm) | Structure of G140A/Q148K HIV-1 intasome with Dolutegravir bound | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... | 著者 | Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. | 登録日 | 2022-12-27 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
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8FNG
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![BU of 8fng by Molmil](/molmil-images/mine/8fng) | Structure of E138K HIV-1 intasome with Dolutegravir bound | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... | 著者 | Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. | 登録日 | 2022-12-27 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
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8FNL
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![BU of 8fnl by Molmil](/molmil-images/mine/8fnl) | Structure of E138K/Q148K HIV-1 intasome with Dolutegravir bound | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... | 著者 | Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. | 登録日 | 2022-12-27 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
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8FNN
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![BU of 8fnn by Molmil](/molmil-images/mine/8fnn) | Structure of E138K/G140A/Q148K HIV-1 intasome with Dolutegravir bound | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... | 著者 | Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. | 登録日 | 2022-12-27 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
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