7UE1
HIV-1 Integrase Catalytic Core Domain Mutant (KGD) in Complex with Inhibitor GRL-142
Summary for 7UE1
Entry DOI | 10.2210/pdb7ue1/pdb |
Descriptor | Integrase, (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, SULFATE ION (3 entities in total) |
Functional Keywords | inhibitor, viral protein |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 37144.33 |
Authors | Aoki, M.,Aoki-Ogata, H.,Bulut, H.,Hayashi, H.,Davis, D.,Hasegawa, K.,Yarchoan, R.,Ghosh, A.K.,Pau, A.K.,Mitsuya, H. (deposition date: 2022-03-21, release date: 2023-03-22, Last modification date: 2024-04-24) |
Primary citation | Aoki, M.,Aoki-Ogata, H.,Bulut, H.,Hayashi, H.,Takamune, N.,Kishimoto, N.,Tanaka, H.,Higashi-Kuwata, N.,Hattori, S.I.,Das, D.,Venkateswara Rao, K.,Iwama, K.,Davis, D.A.,Hasegawa, K.,Murayama, K.,Yarchoan, R.,Ghosh, A.K.,Pau, A.K.,Machida, S.,Misumi, S.,Mitsuya, H. GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants. Sci Adv, 9:eadg2955-eadg2955, 2023 Cited by PubMed: 37436982DOI: 10.1126/sciadv.adg2955 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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