7UE1
HIV-1 Integrase Catalytic Core Domain Mutant (KGD) in Complex with Inhibitor GRL-142
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase | polymer | 166 | 18170.7 | 2 | UniProt (Q9YUI7) Pfam (PF00665) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | C (B) | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate | non-polymer | 706.8 | 1 | Chemie (7OA) | |||
| 3 | D (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A, B: 50 - 212 (UniProt: Q9YUI7)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| His 49 | - | expression tag |
| Ile 74 | Leu 74 | conflict |
| Val 121 | Phe 121 | conflict |
| Ala 125 | Thr 125 | conflict |
| Arg 148 | Gln 148 | conflict |
| Val 151 | Ile 151 | conflict |
| His 185 | Phe 185 | conflict |
| Leu 208 | Ile 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36341.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 802.9 | |
| All* | Total formula weight | 37144.3 |
