5M25
| Modulation of MLL1 Methyltransferase Activity | 分子名称: | (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-~{N}-[(2~{S})-1-[[4-[(~{E})-[4-(hydroxymethyl)phenyl]diazenyl]phenyl]methylamino]-1-oxidanylidene-propan-2-yl]pentanamide, WD repeat-containing protein 5 | 著者 | Srinivasan, V. | 登録日 | 2016-10-11 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem Sci, 8, 2017
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8QXB
| TDP-43 amyloid fibrils: Morphology-2 | 分子名称: | TAR DNA-binding protein 43 | 著者 | Sharma, K, Shenoy, J, Loquet, A, Schmidt, M, Faendrich, M. | 登録日 | 2023-10-24 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils. Nat Commun, 15, 2024
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8QXA
| TDP-43 amyloid fibrils: Morphology-1b | 分子名称: | TAR DNA-binding protein 43 | 著者 | Sharma, K, Shenoy, J, Loquet, A, Schmidt, M, Faendrich, M. | 登録日 | 2023-10-24 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | 主引用文献 | Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils. Nat Commun, 15, 2024
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1BAR
| THREE-DIMENSIONAL STRUCTURES OF ACIDIC AND BASIC FIBROBLAST GROWTH FACTORS | 分子名称: | ACIDIC FIBROBLAST GROWTH FACTOR | 著者 | Zhu, X, Komiya, H, Chirino, A, Faham, S, Fox, G.M, Arakawa, T, Hsu, B.T, Rees, D.C. | 登録日 | 1992-09-29 | 公開日 | 1993-10-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Three-dimensional structures of acidic and basic fibroblast growth factors. Science, 251, 1991
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5FGO
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7XUZ
| Crystal structure of a HDAC4-MEF2A-DNA ternary complex | 分子名称: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | 著者 | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | 登録日 | 2022-05-20 | 公開日 | 2023-11-29 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (3.591 Å) | 主引用文献 | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. Nucleic Acids Res., 52, 2024
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6Y4V
| Crystal structure of p38 in complex with SR68 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Chaikuad, A, Roehm, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-23 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
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6YJC
| Crystal structure of p38alpha in complex with SR154 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-oxidanylidene-1-piperazin-1-yl-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Joerger, A.C, Schroeder, M, Roehm, S, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-04-02 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.74100935 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
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4XNE
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | 1-phenyl-1H-1,2,4-triazole-3,5-diamine, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-15 | 公開日 | 2015-08-12 | 最終更新日 | 2015-08-19 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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6Y6V
| p38a bound with MCP-81 | 分子名称: | 5-azanyl-~{N}-[[4-[[5-~{tert}-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Schroeder, M, Roehm, S, Knapp, S, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-27 | 公開日 | 2020-03-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
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6YK7
| Crystal structure of p38 in complex with SR43 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-(ethylamino)-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Chaikuad, A, Roehm, S, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-04-05 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
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4XP2
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | 1-phenyl-1H-1,2,4-triazole-3,5-diamine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-16 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.748 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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4NFZ
| Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10 | 分子名称: | MANGANESE (II) ION, Polymerase PA | 著者 | Tefsen, B, Lu, G, Zhu, Y, Haywood, J, Zhao, L, Deng, T, Qi, J, Gao, G.F. | 登録日 | 2013-11-01 | 公開日 | 2013-12-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity J.Virol., 88, 2014
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6Y4W
| Crystal structure of p38 in complex with SR69 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-(cyclohexylamino)-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Chaikuad, A, Roehm, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-23 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
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4XOZ
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-16 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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4XRL
| Crystal structure at room temperature of Erk2 in complex with an inhibitor | 分子名称: | 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-21 | 公開日 | 2016-03-23 | 最終更新日 | 2016-03-30 | 実験手法 | X-RAY DIFFRACTION (2.554 Å) | 主引用文献 | Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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4XOY
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | 2-amino-1,9-dihydro-6H-purine-6-thione, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-16 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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4XP0
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-16 | 公開日 | 2015-08-12 | 最終更新日 | 2017-09-06 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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4XRJ
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-21 | 公開日 | 2015-08-12 | 最終更新日 | 2015-08-19 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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6WWA
| Crystal structure of human SHLD2-SHLD3-REV7 complex | 分子名称: | Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 2,Shieldin complex subunit 3 chimera | 著者 | Xie, W, Patel, D.J. | 登録日 | 2020-05-08 | 公開日 | 2021-03-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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6WW9
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6ZWR
| p38a bound with SR92 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-oxidanylidene-1-(pyridin-4-ylmethylamino)butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Schroeder, M, Roehm, S, Knapp, S, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Structural Genomics Consortium (SGC) | 登録日 | 2020-07-28 | 公開日 | 2020-08-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
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1VYM
| NATIVE HUMAN PCNA | 分子名称: | PROLIFERATING CELL NUCLEAR ANTIGEN | 著者 | Kontopidis, G, Wu, S, Zheleva, D, Taylor, P, Mcinnes, C, Lane, D, Fischer, P, Walkinshaw, M. | 登録日 | 2004-05-03 | 公開日 | 2005-01-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design Proc.Natl.Acad.Sci.USA, 102, 2005
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1VYJ
| Structural and biochemical studies of human PCNA complexes provide the basis for association with CDK/cyclin and rationale for inhibitor design | 分子名称: | PROLIFERATING CELL NUCLEAR ANTIGEN, SMALL PEPTIDE SAVLQKKITDYFHPKK | 著者 | Kontopidis, G, Wu, S, Zheleva, D, Taylor, P, Mcinnes, C, Lane, D, Fischer, P, Walkinshaw, M.D. | 登録日 | 2004-04-30 | 公開日 | 2005-01-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design Proc.Natl.Acad.Sci.USA, 102, 2005
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4XP3
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | 2-amino-1,9-dihydro-6H-purine-6-thione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-16 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.782 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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